دورية أكاديمية
أعرض في EDS

Fatty acid binding protein 1 (FABP1) and fatty acid binding protein 2 (FABP2) as a link between diabetic nephropathy and subclinical atherosclerosis in children and adolescents with type 1 diabetes.

التفاصيل البيبلوغرافية
العنوان: Fatty acid binding protein 1 (FABP1) and fatty acid binding protein 2 (FABP2) as a link between diabetic nephropathy and subclinical atherosclerosis in children and adolescents with type 1 diabetes.
المؤلفون: Abo El-Asrar M; Pediatric Departments, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Ismail EAR; Clinical Pathology Departments, Faculty of Medicine, Ain Shams University, Cairo, Egypt. Electronic address: eman.ismail_70@yahoo.com., Elnhrawy AM; General Practitioner, Ministry of Health, Cairo, Egypt., Thabet RA; Pediatric Departments, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
المصدر: Journal of diabetes and its complications [J Diabetes Complications] 2023 Mar; Vol. 37 (3), pp. 108414. Date of Electronic Publication: 2023 Feb 03.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Pub. Co Country of Publication: United States NLM ID: 9204583 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-460X (Electronic) Linking ISSN: 10568727 NLM ISO Abbreviation: J Diabetes Complications Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Elsevier Science Pub. Co., c1992-
مواضيع طبية MeSH: Diabetes Mellitus, Type 1* , Diabetic Nephropathies*/complications , Diabetes Mellitus, Type 2*/complications , Atherosclerosis*, Humans ; Child ; Adolescent ; Carotid Intima-Media Thickness ; Glycated Hemoglobin ; Fatty Acid-Binding Proteins ; Biomarkers
مستخلص: Background: Diabetic nephropathy is a major cause of morbidity and mortality in type 1 diabetes mellitus (T1DM). Fatty acid binding proteins (FABP1 and FABP2) play a role in the development and progression of chronic kidney disease including type 2 diabetes mellitus.
Aim: We assessed serum FABP1 and FABP2 levels in children and adolescents with T1DM as potential markers for diabetic nephropathy and their relation to carotid intima media thickness (CIMT).
Methods: Sixty patients with T1DM were divided into 2 groups according to the presence of nephropathy and compared with 30 healthy controls. CIMT, fasting blood glucose (FBG), hemoglobin A1c (HbA1c), urinary albumin creatinine ratio (UACR), fasting lipid profile and serum FABP1 and FABP2 levels were assessed.
Results: FABP1 and FABP2 levels were significantly higher among type 1 diabetic patient with and without nephropathy compared with healthy controls with the highest levels among patients with nephropathy (p < 0.001). There were significant positive correlations between FABP1 and FABP2 and each of systolic blood pressure, CIMT, FBG, HbA1c and total cholesterol among T1DM patients. FABP1 was negatively correlated to glomerular filtration rate. Multivariable linear regression analysis showed that systolic blood pressure, CIMT, FBG and HbA1c were the significant independent variables related to FABP1 levels in type 1 diabetic patients with nephropathy. ROC curve analysis was performed to determine the cutoff value of FABP1 and FABP2 that could detect nephropathy.
Conclusion: FABP1 and FABP2 levels are elevated in children and adolescents with T1DM and could represent a link between diabetic nephropathy and subclinical atherosclerosis.
Competing Interests: Declaration of competing interest None.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: CIMT; Diabetic nephropathy; FABP1; FABP2; Type 1 diabetes
المشرفين على المادة: 0 (Glycated Hemoglobin)
0 (Fatty Acid-Binding Proteins)
0 (Biomarkers)
0 (FABP2 protein, human)
0 (FABP1 protein, human)
تواريخ الأحداث: Date Created: 20230209 Date Completed: 20230228 Latest Revision: 20230404
رمز التحديث: 20240628
DOI: 10.1016/j.jdiacomp.2023.108414
PMID: 36758511
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-460X
DOI:10.1016/j.jdiacomp.2023.108414