دورية أكاديمية
Phase separation enhances probability of receptor signalling and drug targeting.
| العنوان: | Phase separation enhances probability of receptor signalling and drug targeting. |
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| المؤلفون: | Ladbury JE; School of Molecular and Cellular Biology, University of Leeds, Leeds, LS2 9JT, UK. Electronic address: j.e.ladbury@leeds.ac.uk., Lin CC; School of Molecular and Cellular Biology, University of Leeds, Leeds, LS2 9JT, UK., Suen KM; School of Molecular and Cellular Biology, University of Leeds, Leeds, LS2 9JT, UK. |
| المصدر: | Trends in biochemical sciences [Trends Biochem Sci] 2023 May; Vol. 48 (5), pp. 428-436. Date of Electronic Publication: 2023 Feb 07. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Trends Journals Country of Publication: England NLM ID: 7610674 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 0968-0004 (Print) Linking ISSN: 09680004 NLM ISO Abbreviation: Trends Biochem Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Cambridge (Eng) : Elsevier Trends Journals Original Publication: Amsterdam, Published for the International Union of Biochemistry by Elsevier Scientific Pub. Co. |
| مواضيع طبية MeSH: | Receptor Protein-Tyrosine Kinases*/metabolism , Signal Transduction*/physiology, Probability ; Drug Delivery Systems |
| مستخلص: | The probability of a given receptor tyrosine kinase (RTK) triggering a defined cellular outcome is low because of the promiscuous nature of signalling, the randomness of molecular diffusion through the cell, and the ongoing nonfunctional submembrane signalling activity or noise. Signal transduction is therefore a 'numbers game', where enough cell surface receptors and effector proteins must initially be engaged to guarantee formation of a functional signalling complex against a background of redundant events. The presence of intracellular liquid-liquid phase separation (LLPS) at the plasma membrane provides a mechanism through which the probabilistic nature of signalling can be weighted in favour of the required, discrete cellular outcome and mutual exclusivity in signal initiation. Competing Interests: Declaration of interests None are declared by the authors. (Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.) |
| معلومات مُعتمدة: | 22356 United Kingdom CRUK_ Cancer Research UK |
| فهرسة مساهمة: | Keywords: phase separation kinase signalling; protein condensate; protein droplet |
| المشرفين على المادة: | EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases) |
| تواريخ الأحداث: | Date Created: 20230209 Date Completed: 20230418 Latest Revision: 20240214 |
| رمز التحديث: | 20240214 |
| DOI: | 10.1016/j.tibs.2023.01.005 |
| PMID: | 36759237 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0968-0004 |
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| DOI: | 10.1016/j.tibs.2023.01.005 |