دورية أكاديمية
Noninvasive evaluation of PD-L1 expression in non-small cell lung cancer by immunoPET imaging using an acylating agent-modified antibody fragment.
العنوان: | Noninvasive evaluation of PD-L1 expression in non-small cell lung cancer by immunoPET imaging using an acylating agent-modified antibody fragment. |
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المؤلفون: | Cheng Y; Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai, 200032, China., Shi D; Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai, 200032, China., Ye R; Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai, 200032, China., Fu W; Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai, 200032, China., Ma P; Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai, 200032, China., Si Z; Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai, 200032, China., Xu Z; Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai, 200032, China., Li L; Department of Hepatic Oncology, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai, 200032, China., Lin Q; Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai, 200032, China. lin.qingyu@zs-hospital.sh.cn.; Institute of Nuclear Medicine, Fudan University, Shanghai, 200032, China. lin.qingyu@zs-hospital.sh.cn.; Shanghai Institute of Medical Imaging, Shanghai, 200032, China. lin.qingyu@zs-hospital.sh.cn., Cheng D; Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai, 200032, China. cheng.dengfeng@zs-hospital.sh.cn.; Institute of Nuclear Medicine, Fudan University, Shanghai, 200032, China. cheng.dengfeng@zs-hospital.sh.cn.; Shanghai Institute of Medical Imaging, Shanghai, 200032, China. cheng.dengfeng@zs-hospital.sh.cn. |
المصدر: | European journal of nuclear medicine and molecular imaging [Eur J Nucl Med Mol Imaging] 2023 May; Vol. 50 (6), pp. 1585-1596. Date of Electronic Publication: 2023 Feb 10. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Springer-Verlag Berlin Country of Publication: Germany NLM ID: 101140988 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1619-7089 (Electronic) Linking ISSN: 16197070 NLM ISO Abbreviation: Eur J Nucl Med Mol Imaging Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Berlin : Springer-Verlag Berlin, 2002- |
مواضيع طبية MeSH: | Carcinoma, Non-Small-Cell Lung* , Lung Neoplasms*/diagnostic imaging, Humans ; Immunoglobulin Fab Fragments/metabolism ; Tissue Distribution ; B7-H1 Antigen/metabolism ; Radiopharmaceuticals |
مستخلص: | Purpose: The aim of this study was to explore an effective 124 I labeling strategy and improve the signal-to-noise ratio when evaluating the expression of PD-L1 using an 124 I-iodinated durvalumab (durva) F(ab') Methods: The prepared durva F(ab') Results: After being modified with SHPP, the average conjugation number of SHPP per durva-F(ab') Conclusions: A PD-L1 PET imaging probe [ 124 I]I-HPP-durva F(ab') (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) |
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معلومات مُعتمدة: | 11875114 National Natural Science Foundation of China; 82172002 National Natural Science Foundation of China; 82272058 National Natural Science Foundation of China; 21XD1423500 Shanghai Municipal Science and Technology Committee of the Shanghai Outstanding Young Academic Leaders Plan; 2020ZSLC20 Zhongshan Hospital, Fudan university |
فهرسة مساهمة: | Keywords: F(ab')2 fragment; I-124; PD-L1; PET imaging; SHPP |
المشرفين على المادة: | 0 (Iodine-124) 0 (Immunoglobulin Fab Fragments) 0 (B7-H1 Antigen) 0 (Radiopharmaceuticals) |
تواريخ الأحداث: | Date Created: 20230209 Date Completed: 20230424 Latest Revision: 20230425 |
رمز التحديث: | 20231215 |
DOI: | 10.1007/s00259-023-06130-6 |
PMID: | 36759371 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1619-7089 |
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DOI: | 10.1007/s00259-023-06130-6 |