دورية أكاديمية
Resting coronary flow drives the daily pattern in coronary flow reserve in patients with chest pain without obstructive epicardial stenosis.
| العنوان: | Resting coronary flow drives the daily pattern in coronary flow reserve in patients with chest pain without obstructive epicardial stenosis. |
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| المؤلفون: | Thosar SS; Oregon Institute of Occupational Health Sciences, Portland, OR, United States.; OHSU Knight Cardiovascular Institute, School of Medicine, Portland, OR, United States.; OHSU School of Nursing, Portland, OR, United States.; OHSU-PSU School of Public Health, Oregon Health & Science University, Portland, OR, United States., Taqui S; OHSU Knight Cardiovascular Institute, School of Medicine, Portland, OR, United States., Davidson B; OHSU Knight Cardiovascular Institute, School of Medicine, Portland, OR, United States., Belcik T; OHSU Knight Cardiovascular Institute, School of Medicine, Portland, OR, United States., Hodovan J; OHSU Knight Cardiovascular Institute, School of Medicine, Portland, OR, United States., Rice SPM; Oregon Institute of Occupational Health Sciences, Portland, OR, United States., Lindner JR; Division of Cardiovascular Medicine, Robert M. Berne Cardiovascular Research Center, Charlottesville, VA, United States. |
| المصدر: | Frontiers in cardiovascular medicine [Front Cardiovasc Med] 2023 Jan 25; Vol. 10, pp. 1057692. Date of Electronic Publication: 2023 Jan 25 (Print Publication: 2023). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101653388 Publication Model: eCollection Cited Medium: Print ISSN: 2297-055X (Print) Linking ISSN: 2297055X NLM ISO Abbreviation: Front Cardiovasc Med Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Lausanne : Frontiers Media S.A., [2014]- |
| مستخلص: | Objectives: Ischemia with no obstructive coronary artery disease (INOCA) is a risk factor for major adverse cardiovascular events and is characterized by abnormal coronary microvascular tone. In patients with INOCA, adverse cardiovascular events most commonly occur in the morning compared to other times of the day and night. Materials and Methods: We tested whether coronary microvascular function varies diurnally with attenuation in the morning in patients with symptomatic coronary artery disease without significant (>50%) epicardial stenosis. We evaluated data from 17 patients studied in the AM (700-1159 h) and 11 patients in the PM (1200-1800 h). Coronary microvascular function was measured using perfusion contrast imaging at rest and after infusion of intravenous regadenoson. We calculated microvascular flow reserve as the ratio of hyperemic to resting flow. Along with independent sample t -tests, we performed bootstrapping procedures to test mean differences between AM and PM groups, using the bias-corrected and accelerated method with 5,000 bootstrapped samples. Results and Conclusion: The AM and PM groups were matched for demographic and existing risk factors. Coronary microvascular flow reserve was ∼33% higher in the AM compared to the PM ( P = 0.025, BCa 95% CI [0.25, 1.64]; Hedge's g = 0.89, 95% CI [0.11, 1.66]) as a result of significantly lower resting flow (∼50%) in the AM compared to the PM ( P = 0.03, M Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Thosar, Taqui, Davidson, Belcik, Hodovan, Rice and Lindner.) |
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| معلومات مُعتمدة: | KL2 TR002370 United States TR NCATS NIH HHS; R01 HL163232 United States HL NHLBI NIH HHS |
| فهرسة مساهمة: | Keywords: coronary flow reserve; diurnal variation; ischemia and non-obstructive coronary artery disease; microvascular dysfunction; myocardial contrast echocardiography; perfusion imaging; regadenoson stress |
| تواريخ الأحداث: | Date Created: 20230210 Latest Revision: 20240625 |
| رمز التحديث: | 20240625 |
| مُعرف محوري في PubMed: | PMC9905716 |
| DOI: | 10.3389/fcvm.2023.1057692 |
| PMID: | 36760564 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2297-055X |
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| DOI: | 10.3389/fcvm.2023.1057692 |