دورية أكاديمية
Design and synthesis of atorvastatin derivatives with enhanced water solubility, hepatoselectivity and stability.
| العنوان: | Design and synthesis of atorvastatin derivatives with enhanced water solubility, hepatoselectivity and stability. |
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| المؤلفون: | Maklakova SY; Chemistry Department, Lomonosov Moscow State University GSP-1, Leninskie Gory 1/3 Moscow 119991 Russian Federation maklakovaSU@yandex.ru., Lopukhov AV; Chemistry Department, Lomonosov Moscow State University GSP-1, Leninskie Gory 1/3 Moscow 119991 Russian Federation maklakovaSU@yandex.ru., Khudyakov AD; Chemistry Department, Lomonosov Moscow State University GSP-1, Leninskie Gory 1/3 Moscow 119991 Russian Federation maklakovaSU@yandex.ru., Kovalev SV; Chemistry Department, Lomonosov Moscow State University GSP-1, Leninskie Gory 1/3 Moscow 119991 Russian Federation maklakovaSU@yandex.ru., Mazhuga MP; Chemistry Department, Lomonosov Moscow State University GSP-1, Leninskie Gory 1/3 Moscow 119991 Russian Federation maklakovaSU@yandex.ru., Chepikova OE; Department of Biotechnology, Sirius University of Science and Technology Olympic Avenue 1 Sochi 354340 Russian Federation., Zamyatnin AA Jr; Department of Biotechnology, Sirius University of Science and Technology Olympic Avenue 1 Sochi 354340 Russian Federation.; Institute of Molecular Medicine, Sechenov First Moscow State Medical University Trubetskaya Street 8/2 Moscow 119991 Russian Federation.; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University GSP-1, Leninskie Gory Moscow 119992 Russian Federation.; Faculty of Health and Medical Sciences, University of Surrey Guildford GU2 7XH UK., Majouga AG; Chemistry Department, Lomonosov Moscow State University GSP-1, Leninskie Gory 1/3 Moscow 119991 Russian Federation maklakovaSU@yandex.ru.; Dmitry Mendeleev University of Chemical Technology of Russia Miusskaya Square 9 Moscow 125047 Russian Federation., Klyachko NL; Chemistry Department, Lomonosov Moscow State University GSP-1, Leninskie Gory 1/3 Moscow 119991 Russian Federation maklakovaSU@yandex.ru., Beloglazkina EK; Chemistry Department, Lomonosov Moscow State University GSP-1, Leninskie Gory 1/3 Moscow 119991 Russian Federation maklakovaSU@yandex.ru. |
| المصدر: | RSC medicinal chemistry [RSC Med Chem] 2022 Oct 11; Vol. 14 (1), pp. 56-64. Date of Electronic Publication: 2022 Oct 11 (Print Publication: 2023). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101759460 Publication Model: eCollection Cited Medium: Internet ISSN: 2632-8682 (Electronic) Linking ISSN: 26328682 NLM ISO Abbreviation: RSC Med Chem Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge : Royal Society of Chemistry, [2020]- |
| مستخلص: | Statins are effective 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-R) inhibitors, which are successfully used for cardiovascular disease treatment. Statins' side effects are generally attributed to poor bioavailability and hepatoselectivity, which are closely related to their high lipophilicity. Targeted delivery of statins to the liver is considered as a way to reduce unwanted side effects. Herein we report on synthesis and evaluation of atorvastatin conjugates targeting the galactose-specific hepatic asialoglycoprotein receptor (ASGPR). The prepared conjugates showed greater water solubility compared to unmodified atorvastatin. The synthesised compounds demonstrated potent binding to the ASGPR with submicromolar K Competing Interests: There are no conflicts to declare. (This journal is © The Royal Society of Chemistry.) |
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| تواريخ الأحداث: | Date Created: 20230210 Latest Revision: 20231012 |
| رمز التحديث: | 20231012 |
| مُعرف محوري في PubMed: | PMC9890652 |
| DOI: | 10.1039/d2md00119e |
| PMID: | 36760736 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2632-8682 |
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| DOI: | 10.1039/d2md00119e |