دورية أكاديمية
أعرض في EDS

Field investigation of high reported non-neonatal tetanus burden in Uganda, 2016-2017.

التفاصيل البيبلوغرافية
العنوان: Field investigation of high reported non-neonatal tetanus burden in Uganda, 2016-2017.
المؤلفون: Casey RM; Global Immunization Division, Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA., Nguna J; Expanded Programme on Immunization, Ministry of Health, Kampala, Uganda., Opar B; Expanded Programme on Immunization, Ministry of Health, Kampala, Uganda., Ampaire I; Expanded Programme on Immunization, Ministry of Health, Kampala, Uganda., Lubwama J; Division of Global HIV and Tuberculosis, Centers for Disease Control and Prevention, Kampala, Uganda., Tanifum P; Global Immunization Division, Centers for Disease Control and Prevention, Kampala, Uganda., Zhu BP; Division of Global Health Protection, Centers for Disease Control and Prevention, Kampala, Uganda., Kisakye A; World Health Organization, Country Office, Kampala, Uganda., Kabwongera E; UNICEF, Country Office, Kampala, Uganda., Tohme RA; Global Immunization Division, Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA., Dahl BA; Global Immunization Division, Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA., Ridpath AD; Global Immunization Division, Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA., Scobie HM; Global Immunization Division, Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA.
المصدر: International journal of epidemiology [Int J Epidemiol] 2023 Aug; Vol. 52 (4), pp. 1150-1162. Date of Electronic Publication: 2023 Feb 10.
نوع المنشور: Journal Article; Research Support, U.S. Gov't, P.H.S.
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 7802871 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3685 (Electronic) Linking ISSN: 03005771 NLM ISO Abbreviation: Int J Epidemiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] Oxford University Press.
مواضيع طبية MeSH: Tetanus*/epidemiology, Humans ; Uganda/epidemiology ; Cost of Illness ; Incidence ; Tetanus Toxoid ; Male ; Female ; Infant ; Child, Preschool ; Child ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Aged ; Aged, 80 and over ; Risk Factors ; Vaccination/statistics & numerical data
مستخلص: Background: Despite providing tetanus-toxoid-containing vaccine (TTCV) to infants and reproductive-age women, Uganda reports one of the highest incidences of non-neonatal tetanus (non-NT). Prompted by unusual epidemiologic trends among reported non-NT cases, we conducted a retrospective record review to see whether these data reflected true disease burden.
Methods: We analysed nationally reported non-NT cases during 2012-2017. We visited 26 facilities (14 hospitals, 12 health centres) reporting high numbers of non-NT cases (n = 20) or zero cases (n = 6). We identified non-NT cases in facility registers during 1 January 2016-30 June 2017; the identified case records were abstracted.
Results: During 2012-2017, a total of 24 518 non-NT cases were reported and 74% were ≥5 years old. The average annual incidence was 3.43 per 100 000 population based on inpatient admissions. Among 482 non-NT inpatient cases reported during 1 January 2016-30 June 2017 from hospitals visited, 342 (71%) were identified in facility registers, despite missing register data (21%). Males comprised 283 (83%) of identified cases and 60% were ≥15 years old. Of 145 cases with detailed records, 134 (92%) were clinically confirmed tetanus; among these, the case-fatality ratio (CFR) was 54%. Fourteen cases were identified at two hospitals reporting zero cases. Among >4000 outpatient cases reported from health centres visited, only 3 cases were identified; the remainder were data errors.
Conclusions: A substantial number of non-NT cases and deaths occur in Uganda. The high CFR and high non-NT burden among men and older children indicate the need for TTCV booster doses across the life course to all individuals as well as improved coverage with the TTCV primary series. The observed data errors indicate the need for data quality improvement activities.
(Published by Oxford University Press on behalf of the International Epidemiological Association 2023.)
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معلومات مُعتمدة: 001 International WHO_ World Health Organization; CC999999 United States ImCDC Intramural CDC HHS
فهرسة مساهمة: Keywords: Tetanus; Uganda; booster immunization; data quality; public health surveillance; tetanus toxoid; vaccination
المشرفين على المادة: 0 (Tetanus Toxoid)
تواريخ الأحداث: Date Created: 20230210 Date Completed: 20230804 Latest Revision: 20231204
رمز التحديث: 20231205
مُعرف محوري في PubMed: PMC10413815
DOI: 10.1093/ije/dyad005
PMID: 36762894
قاعدة البيانات: MEDLINE
الوصف
تدمد:1464-3685
DOI:10.1093/ije/dyad005