دورية أكاديمية
RUNX3 in Stem Cell and Cancer Biology.
| العنوان: | RUNX3 in Stem Cell and Cancer Biology. |
|---|---|
| المؤلفون: | Chuang LSH; Cancer Science Institute of Singapore, NUS Centre for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, 14 Medical Drive #12-01, Singapore 117599, Singapore., Matsuo J; Cancer Science Institute of Singapore, NUS Centre for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, 14 Medical Drive #12-01, Singapore 117599, Singapore., Douchi D; Department of Surgery, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan., Bte Mawan NA; Cancer Science Institute of Singapore, NUS Centre for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, 14 Medical Drive #12-01, Singapore 117599, Singapore., Ito Y; Cancer Science Institute of Singapore, NUS Centre for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, 14 Medical Drive #12-01, Singapore 117599, Singapore. |
| المصدر: | Cells [Cells] 2023 Jan 25; Vol. 12 (3). Date of Electronic Publication: 2023 Jan 25. |
| نوع المنشور: | Journal Article; Review; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI |
| مواضيع طبية MeSH: | Core Binding Factor alpha Subunits*/genetics , Core Binding Factor alpha Subunits*/metabolism , Neoplasms*/genetics, Animals ; Mice ; Biology ; Mammals/metabolism ; Mutation ; Signal Transduction ; Humans |
| مستخلص: | The runt-related transcription factors (RUNX) play prominent roles in cell cycle progression, differentiation, apoptosis, immunity and epithelial-mesenchymal transition. There are three members in the mammalian RUNX family, each with distinct tissue expression profiles. RUNX genes play unique and redundant roles during development and adult tissue homeostasis. The ability of RUNX proteins to influence signaling pathways, such as Wnt, TGFβ and Hippo-YAP, suggests that they integrate signals from the environment to dictate cell fate decisions. All RUNX genes hold master regulator roles, albeit in different tissues, and all have been implicated in cancer. Paradoxically, RUNX genes exert tumor suppressive and oncogenic functions, depending on tumor type and stage. Unlike RUNX1 and 2, the role of RUNX3 in stem cells is poorly understood. A recent study using cancer-derived RUNX3 mutation R122C revealed a gatekeeper role for RUNX3 in gastric epithelial stem cell homeostasis. The corpora of RUNX3 R122C/R122C mice showed a dramatic increase in proliferating stem cells as well as inhibition of differentiation. Tellingly, RUNX3 R122C/R122C mice also exhibited a precancerous phenotype. This review focuses on the impact of RUNX3 dysregulation on (1) stem cell fate and (2) the molecular mechanisms underpinning early carcinogenesis. |
| References: | Nat Cell Biol. 2017 Jul;19(7):774-786. (PMID: 28581476) Clin Breast Cancer. 2017 Feb;17(1):1-10. (PMID: 27561704) Nature. 2012 Jun 20;486(7403):405-9. (PMID: 22722202) Dev Biol. 2007 Sep 15;309(2):259-72. (PMID: 17706957) Gastroenterology. 2014 Jun;146(7):1727-38.e8. (PMID: 24534633) Cell Rep. 2014 Jul 10;8(1):50-8. (PMID: 25008775) Biochem Biophys Res Commun. 2004 Aug 13;321(1):58-64. (PMID: 15358215) Nat Rev Cancer. 2012 Jun 22;12(7):465-77. (PMID: 22722403) Oncogene. 2004 May 24;23(24):4211-9. (PMID: 15156175) Prostate. 2021 Mar;81(4):231-241. (PMID: 33411419) J Immunol. 1998 Dec 15;161(12):6751-60. (PMID: 9862705) Nat Immunol. 2008 Oct;9(10):1131-9. (PMID: 18776905) Nat Commun. 2016 Feb 26;7:10751. (PMID: 26916619) Cell. 2004 Aug 20;118(4):409-18. (PMID: 15315754) J Biol Chem. 2008 Jun 20;283(25):17324-32. (PMID: 18430739) Cell. 1997 May 30;89(5):765-71. (PMID: 9182764) EBioMedicine. 2016 Jun;8:117-131. (PMID: 27428424) Cancer. 2012 Nov 15;118(22):5507-17. (PMID: 22576578) Int J Cancer. 2013 Mar 15;132(6):1260-71. (PMID: 23180629) Nat Immunol. 2019 Oct;20(10):1372-1380. (PMID: 31451789) Cell. 2002 Apr 5;109(1):113-24. (PMID: 11955451) EMBO J. 2012 Nov 5;31(21):4124-39. (PMID: 23034403) J Natl Cancer Inst. 2017 Aug 1;109(8):. (PMID: 28423402) Nat Rev Cancer. 2008 Sep;8(9):671-82. (PMID: 18650841) Cancer Metastasis Rev. 2006 Dec;25(4):589-600. (PMID: 17165130) Gastroenterology. 2011 May;140(5):1536-46.e8. (PMID: 21277301) Nature. 2009 Aug 27;460(7259):1140-4. (PMID: 19668186) Gut. 2021 Oct;70(10):1833-1846. (PMID: 33293280) Nat Commun. 2019 Apr 23;10(1):1897. (PMID: 31015486) Cell. 2006 Apr 21;125(2):301-13. (PMID: 16630818) Cancer Res. 2005 Sep 1;65(17):7743-50. (PMID: 16140942) EMBO J. 2018 Apr 3;37(7):. (PMID: 29467218) Blood. 2017 Apr 13;129(15):2070-2082. (PMID: 28179279) Cell Res. 2009 Nov;19(11):1227-8. (PMID: 19881523) J Cell Physiol. 2009 Mar;218(3):473-9. (PMID: 19006109) Nat Rev Mol Cell Biol. 2012 Oct;13(10):616-30. (PMID: 22992590) Cancer Cell. 2013 Nov 11;24(5):603-16. (PMID: 24229708) Gastroenterology. 2021 Jan;160(1):302-316.e7. (PMID: 33010253) Development. 2008 May;135(9):1703-11. (PMID: 18385258) Mol Cell Biol. 2006 Jun;26(12):4474-88. (PMID: 16738314) Leuk Lymphoma. 2018 Sep;59(9):2188-2200. (PMID: 29249175) Gene. 2001 Nov 28;279(2):221-32. (PMID: 11733147) J Biol Chem. 1999 Oct 29;274(44):31577-82. (PMID: 10531362) Cell Mol Gastroenterol Hepatol. 2022;13(5):1317-1345. (PMID: 35074568) Mol Cells. 2020 Feb 29;43(2):107-113. (PMID: 31926543) Blood. 2007 Dec 15;110(13):4188-97. (PMID: 17823307) J Cell Physiol. 2019 Jun;234(6):8597-8609. (PMID: 30515788) J Exp Med. 2007 Aug 6;204(8):1945-57. (PMID: 17646406) Oncogene. 2017 Dec 14;36(50):6884-6894. (PMID: 28846108) Nature. 2006 Jun 29;441(7097):1068-74. (PMID: 16810241) Mol Cell Biol. 2005 Sep;25(18):8097-107. (PMID: 16135801) Biochem Biophys Res Commun. 2009 Oct 23;388(3):496-500. (PMID: 19665002) Nature. 2003 May 15;423(6937):302-5. (PMID: 12714971) Int J Hematol. 2015 Apr;101(4):319-29. (PMID: 25749719) J Clin Invest. 2017 Jun 30;127(7):2815-2828. (PMID: 28530640) J Cell Biochem. 2013 May;114(5):985-93. (PMID: 23150456) Development. 2007 Nov;134(21):3905-15. (PMID: 17933794) Oncogene. 2012 Jan 26;31(4):527-34. (PMID: 21706051) Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14592-7. (PMID: 22912405) Adv Exp Med Biol. 2017;962:299-320. (PMID: 28299665) Stem Cells. 2010 Oct;28(10):1869-81. (PMID: 20799333) Proc Natl Acad Sci U S A. 2016 Jun 7;113(23):6490-5. (PMID: 27217562) Nat Rev Cancer. 2015 Feb;15(2):81-95. (PMID: 25592647) Cancer Res. 2006 Jul 1;66(13):6512-20. (PMID: 16818622) Adv Exp Med Biol. 2017;962:395-413. (PMID: 28299670) Stem Cells. 2012 Oct;30(10):2088-99. (PMID: 22899304) Cell Cycle. 2016 Nov 16;15(22):2999-3000. (PMID: 27494598) Oncogene. 2016 May 19;35(20):2664-74. (PMID: 26364597) Biochim Biophys Acta. 2013 Feb;1830(2):2280-96. (PMID: 22959078) Nature. 2012 Jun 10;486(7403):353-60. (PMID: 22722193) Cancer Res. 2008 Aug 1;68(15):6208-14. (PMID: 18676844) Cancer Cell. 2012 Aug 14;22(2):209-21. (PMID: 22897851) Cell. 2015 Jun 4;161(6):1345-60. (PMID: 26004068) Cell. 1997 May 30;89(5):755-64. (PMID: 9182763) J Immunol. 2015 Aug 15;195(4):1517-23. (PMID: 26170388) Dev Biol. 2005 Nov 15;287(2):262-73. (PMID: 16226243) J Pathol. 2019 Apr;247(4):513-523. (PMID: 30511397) Cancer Res. 2014 Sep 15;74(18):5277-5286. (PMID: 25056120) Gastroenterology. 2021 Jan;160(1):260-271.e10. (PMID: 32956680) BMC Gastroenterol. 2011 Aug 25;11:92. (PMID: 21867527) Cancer Cell. 2008 Sep 9;14(3):226-37. (PMID: 18772112) Cell. 1996 Jan 26;84(2):321-30. (PMID: 8565077) Gastroenterology. 2022 Feb;162(2):415-430. (PMID: 34728185) Development. 2005 Nov;132(22):5043-54. (PMID: 16236764) Gastroenterology. 2017 Jan;152(1):218-231.e14. (PMID: 27670082) J Cell Physiol. 2020 Oct;235(10):7261-7272. (PMID: 32180230) Mol Cell Biol. 2007 May;27(10):3769-79. (PMID: 17339329) Nat Rev Cancer. 2005 May;5(5):376-87. (PMID: 15864279) J Biol Chem. 2010 May 28;285(22):16693-703. (PMID: 20353948) Nat Cell Biol. 2011 Sep 11;13(10):1214-23. (PMID: 21909099) Cell. 2015 Oct 8;163(2):506-19. (PMID: 26451490) Science. 2000 Mar 10;287(5459):1804-8. (PMID: 10710306) |
| فهرسة مساهمة: | Keywords: RUNX3; cancer; cell cycle; differentiation block; early-stage cancer; proliferation; stem cells |
| المشرفين على المادة: | 0 (Core Binding Factor alpha Subunits) |
| تواريخ الأحداث: | Date Created: 20230211 Date Completed: 20230215 Latest Revision: 20230220 |
| رمز التحديث: | 20230220 |
| مُعرف محوري في PubMed: | PMC9913995 |
| DOI: | 10.3390/cells12030408 |
| PMID: | 36766749 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2073-4409 |
|---|---|
| DOI: | 10.3390/cells12030408 |