دورية أكاديمية
Coumarinolignoid and Indole Alkaloids from the Roots of the Hybrid Plant Citrus × paradisi Macfad (Rutaceae).
| العنوان: | Coumarinolignoid and Indole Alkaloids from the Roots of the Hybrid Plant Citrus × paradisi Macfad (Rutaceae). |
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| المؤلفون: | Essombe Malolo FA; Department of Chemistry, Faculty of Sciences, University of Douala, Douala P.O. Box 24157, Cameroon., Kouam ADK; Department of Chemistry, Faculty of Sciences, University of Douala, Douala P.O. Box 24157, Cameroon., Nyobe JCN; Department of Pharmaceutical Sciences, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala P.O. Box 2701, Cameroon., Ngah L; Department of Pharmaceutical Sciences, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala P.O. Box 2701, Cameroon., Frese M; Organic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, 33501 Bielefeld, Germany., Ndom JC; Department of Chemistry, Faculty of Sciences, University of Douala, Douala P.O. Box 24157, Cameroon., Langat MK; Royal Botanic Gardens, Kew, Richmond TW9 3AE, UK., Lenta BN; Organic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, 33501 Bielefeld, Germany.; Department of Chemistry, Higher Teacher Training College, University of Yaoundé 1, Yaoundé P.O. Box 47, Cameroon., Mulholland DA; Natural Products Research Group, Department of Chemistry, Faculty of Engineering and Physical Sciences, University of Surrey, Guildford GU2 7XH, UK., Sewald N; Organic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, 33501 Bielefeld, Germany., Wansi JD; Department of Chemistry, Faculty of Sciences, University of Douala, Douala P.O. Box 24157, Cameroon.; Organic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, 33501 Bielefeld, Germany. |
| المصدر: | Molecules (Basel, Switzerland) [Molecules] 2023 Jan 20; Vol. 28 (3). Date of Electronic Publication: 2023 Jan 20. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI, c1995- |
| مواضيع طبية MeSH: | Rutaceae*/chemistry , Citrus paradisi* , Citrus* , Adenocarcinoma*, Male ; Humans ; Plant Extracts/chemistry ; Indole Alkaloids/analysis ; Plant Roots/chemistry ; Molecular Structure |
| مستخلص: | A phytochemical investigation of the roots of Citrus × paradisi Macfad. (Rutaceae) led to the isolation of two new compounds, namely 1-formyl-5-hydroxy- N -methylindolin-1-ium ( 1 ) and decyloxycleomiscosin D ( 2 ), along with ten known compounds: 1,1-dimethylpyrrolidin-1-ium-2-carboxylate ( 3 ), furan-2,3-diol ( 4 ), 5-methoxyseselin ( 5 ), umbelliferone ( 6 ), scopoletin ( 7 ), citracridone I ( 8 ), citracridone II ( 9 ), citracridone III ( 10 ), limonin ( 11 ) and lupeol ( 12 ). The structures were determined through the comprehensive spectroscopic analysis of 1D and 2D NMR and EI- and ESI-MS, as well as a comparison with the published data. Notably, compounds 3 and 4 from the genus Citrus are reported here for the first time. In addition, the MeOH extract of the roots and compounds 1 - 7 were screened against the human adenocarcinoma alveolar basal epithelial cell line A549 and the Caucasian prostate adenocarcinoma cell line PC3 using the MTT assay. While the extract showed significant activity, with IC Competing Interests: The authors declare no conflict of interest. |
| References: | Nig Q J Hosp Med. 2008 Oct-Dec;18(4):211-5. (PMID: 19391322) Molecules. 2018 Feb 13;23(2):. (PMID: 29438356) Bioorg Med Chem Lett. 2016 Jan 15;26(2):306-309. (PMID: 26711890) Chem Biodivers. 2022 Jul;19(7):e202101033. (PMID: 35678514) J Agric Food Chem. 2005 Dec 14;53(25):9790-4. (PMID: 16332132) Food Chem Toxicol. 2011 Jul;49(7):1549-55. (PMID: 21457747) Arch Pharm Res. 2005 Jan;28(1):34-8. (PMID: 15742805) |
| معلومات مُعتمدة: | IES/R1/180061 Royal Society of Chemistry; the renewed research stay 2021 Alexander von Humboldt Foundation; YaBiNaPA German Academic Exchange Service; Open Access Publication Fund of Bielefeld University Deutsche Forschungsgemeinschaft |
| فهرسة مساهمة: | Keywords: Citrus × paradisi; chemotaxonomy; coumarinolignoid; cytotoxicity; indole alkaloids |
| المشرفين على المادة: | 0 (Plant Extracts) 0 (Indole Alkaloids) |
| تواريخ الأحداث: | Date Created: 20230211 Date Completed: 20230214 Latest Revision: 20230214 |
| رمز التحديث: | 20230214 |
| مُعرف محوري في PubMed: | PMC9921193 |
| DOI: | 10.3390/molecules28031078 |
| PMID: | 36770745 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1420-3049 |
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| DOI: | 10.3390/molecules28031078 |