دورية أكاديمية
أعرض في EDS

Human Tracheal Transplantation.

التفاصيل البيبلوغرافية
العنوان: Human Tracheal Transplantation.
المؤلفون: Genden EM; Department of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, NY., Laitman BM
المصدر: Transplantation [Transplantation] 2023 Aug 01; Vol. 107 (8), pp. 1698-1705. Date of Electronic Publication: 2023 Jul 20.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0132144 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1534-6080 (Electronic) Linking ISSN: 00411337 NLM ISO Abbreviation: Transplantation Subsets: MEDLINE
أسماء مطبوعة: Publication: Hagerstown, MD : Lippincott Williams & Wilkins
Original Publication: Baltimore, Williams & Wilkins.
مواضيع طبية MeSH: Trachea*/blood supply , Trachea*/injuries , Trachea*/pathology , Trachea*/transplantation , Transplantation, Homologous*/adverse effects, Humans ; Tracheoesophageal Fistula/surgery ; Tracheal Diseases/surgery ; Organ Transplantation/methods ; Organ Transplantation/standards ; Organ Transplantation/trends ; Graft Rejection/pathology ; Graft Rejection/prevention & control
مستخلص: Long-segment tracheal airway defects may be congenital or result from burns, trauma, iatrogenic intubation damage, or tumor invasion. Although airway defects <6 cm in length may be reconstructed using existing end-to-end reconstructive techniques, defects >6 cm continue to challenge surgeons worldwide. The reconstruction of long-segment tracheal defects has long been a reconstructive dilemma, and these defects are associated with significant morbidity and mortality. Many of these defects are not compatible with life or require a permanent extended-length tracheostomy that is fraught with complications including mucus plugging and tracheoesophageal fistula. Extensive circumferential tracheal defects require a reconstructive technique that provides a rigid structure able to withstand the inspiratory pressures, a structure that will biologically integrate, and contain functional ciliated epithelium to allow for normal mucociliary clearance. Tracheal transplantation has been considered the reconstructive "Holy Grail;" however, there has been a long-held scientific dogma that revascularization of the trachea was not possible. This dogma stifled research to achieve single-staged vascularized tracheal transplantation and prompted the introduction of many creative and inventive alternatives. Throughout history, alloplastic material, nonvascularized allografts, and homografts have been used to address this dilemma. However, these techniques have largely been unsuccessful. The recent introduction of a technique for single-staged vascularized tracheal transplantation may offer a solution to this dilemma and potentially a solution to management of the fatal tracheoesophageal fistula.
Competing Interests: The authors declare no funding or conflicts of interest.
(Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
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تواريخ الأحداث: Date Created: 20230214 Date Completed: 20231012 Latest Revision: 20231012
رمز التحديث: 20231215
DOI: 10.1097/TP.0000000000004509
PMID: 36782283
قاعدة البيانات: MEDLINE
الوصف
تدمد:1534-6080
DOI:10.1097/TP.0000000000004509