COVID-19 Positive Versus Negative Complete Kawasaki Disease: A Study from the International Kawasaki Disease Registry.

التفاصيل البيبلوغرافية
العنوان:	COVID-19 Positive Versus Negative Complete Kawasaki Disease: A Study from the International Kawasaki Disease Registry.
المؤلفون:	Jose J; Division of Pediatric Cardiology, Lucile Packard Children's Hospital, Stanford University Medical Center, Palo Alto, CA, USA. jtj17@alumni.utsw.edu.; 535 Everett Ave, Apt 101, Palo Alto, CA, 94301, USA. jtj17@alumni.utsw.edu., Tierney ESS; Division of Pediatric Cardiology, Lucile Packard Children's Hospital, Stanford University Medical Center, Palo Alto, CA, USA., Harahsheh AS; Children's National Health System/George Washington University School of Medicine & Health Sciences, Washington, DC, USA., Dahdah N; Division of Pediatric Cardiology, CHU Ste-Justine, University of Montreal, Montreal, Canada., Raghuveer G; Children's Mercy Hospital, Kansas City, MO, USA., Friedman KG; Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Khoury M; Department of Pediatrics, Stollery Children's Hospital, University of Alberta, Edmonton, AB, Canada., Hicar MD; Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA., Merves SA; University of Arkansas for Medical Sciences/Arkansas Children's Hospital, Little Rock, AR, USA., Dallaire F; Centre de recherche du Centre hospitalier universitaire de Sherbrooke, Sherbrooke, QC, Canada., Farid P; Division of Cardiology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada., Manlhiot C; Division of Cardiology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada., Runeckles K; Ted Rogers Computational Program, Peter Munk Cardiac Centre, Ted Rogers Centre for Heart Research, The Hospital for Sick Children, University Health Network, Toronto, ON, Canada., Misra N; Cohen Children's Medical Center of NY, Northwell Health, Queens, NY, USA., Portman M; Seattle Children's Hospital, Seattle, WA, USA., Ballweg JA; Children's Hospital & Medical Center of Omaha, Omaha, NE, USA., Lee S; The Heart Center at Nationwide Children's Hospital, Columbus, OH, USA., Jain SS; New York Medical College/Maria Fareri Children's Hospital at Westchester Medical Center, Valhalla, New York, USA., Harris TH; UPMC Children's Hospital of Pittsburgh, University of Pittsburgh SOM, Pittsburgh, PA, USA., Szmuszkovicz JR; Children's Hospital of Los Angeles, Los Angeles, CA, USA., Orr W; Division of Pediatric Cardiology, Department of Pediatrics, Washington University School of Medicine, St. Louis, USA., Larios G; Pontificia Universidad Católica de Chile, Región Metropolitana, Santiago, Chile., McCrindle BW; Division of Cardiology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
المصدر:	Pediatric cardiology [Pediatr Cardiol] 2023 Aug; Vol. 44 (6), pp. 1373-1381. Date of Electronic Publication: 2023 Feb 14.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Springer Verlag Country of Publication: United States NLM ID: 8003849 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1971 (Electronic) Linking ISSN: 01720643 NLM ISO Abbreviation: Pediatr Cardiol Subsets: MEDLINE
أسماء مطبوعة:	Publication: New York Ny : Springer Verlag Original Publication: [New York, Springer-Verlag]
مواضيع طبية MeSH:	COVID-19* , Mucocutaneous Lymph Node Syndrome/complications , Mucocutaneous Lymph Node Syndrome/diagnosis , Mucocutaneous Lymph Node Syndrome*/drug therapy, Humans ; SARS-CoV-2 ; Stroke Volume ; Ventricular Function, Left ; Systemic Inflammatory Response Syndrome ; Registries
مستخلص:	To determine clinical differences for children with complete Kawasaki disease (KD) with and without evidence of preceding SARS-CoV-2 infection. From January 2020, contemporaneous patients with complete KD criteria were classified as either SARS-CoV-2 positive (KDCOVID+; confirmed household exposure, positive PCR and/or serology) or SARS-CoV-2 negative (KDCOVID-; negative testing and no exposure) and compared. Of 744 patients in the International Kawasaki Disease Registry, 52 were KDCOVID- and 61 were KDCOVID+. KDCOVID+ patients were older (median 5.5 vs. 3.7 years; p < 0.001), and all additionally met diagnostic criteria for multisystem inflammatory syndrome in children (MIS-C). They were more likely to have abdominal pain (60% vs. 35%; p = 0.008) and headache (38% vs. 10%; p < 0.001) and had significantly higher CRP, troponin, and BUN/creatinine, and lower hemoglobin, platelets, and lymphocytes. KDCOVID+ patients were more likely to have shock (41% vs. 6%; p < 0.001), ICU admission (62% vs. 10%; p < 0.001), lower left ventricular ejection fraction (mean lowest LVEF 53% vs. 60%; p < 0.001), and to have received inotropic support (60% vs. 10%; p < 0.001). Both groups received IVIG (2 doses in 22% vs. 18%; p = 0.63), but KDCOVID+ were more likely to have received steroids (85% vs. 35%; p < 0.001) and anakinra (60% vs. 10%; p = 0.002). KDCOVID- patients were more likely to have medium/large coronary artery aneurysms (CAA, 12% vs. 0%; p = 0.01). KDCOVID+ patients differ from KDCOVID-, have more severe disease, and greater evidence of myocardial involvement and cardiovascular dysfunction rather than CAA. These patients may be a distinct KD phenotype in the presence of a prevalent specific trigger. (© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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معلومات مُعتمدة:	R01HL143130 National Institutes of Health
فهرسة مساهمة:	Keywords: COVID-19; Kawasaki; MIS-C; MIS-C with KD phenotype; SARS-CoV-2
SCR Disease Name:	pediatric multisystem inflammatory disease, COVID-19 related
تواريخ الأحداث:	Date Created: 20230214 Date Completed: 20230628 Latest Revision: 20230628
رمز التحديث:	20230628
مُعرف محوري في PubMed:	PMC9926414
DOI:	10.1007/s00246-023-03109-w
PMID:	36786810
قاعدة البيانات:	MEDLINE

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تدمد:	1432-1971
DOI:	10.1007/s00246-023-03109-w