دورية أكاديمية
Multilevel assessment of chlorothalonil sediment toxicity to Latin American estuarine biota: Effects on biomarkers, reproduction and survival in different benthic organisms.
| العنوان: | Multilevel assessment of chlorothalonil sediment toxicity to Latin American estuarine biota: Effects on biomarkers, reproduction and survival in different benthic organisms. |
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| المؤلفون: | Morais LG; Departamento de Ciências do Mar, Universidade Federal de São Paulo, Campus Baixada Santista, Rua Maria Máximo, 168, Ponta da Praia, Santos/SP, CEP: 11030-100 Santos, Brazil; Campus do Litoral Paulista, Universidade Estadual Paulista Júlio de Mesquita Filho - Unesp, Praça Infante Dom Henrique, s/n, CP 11330-900 São Vicente, SP, Brazil., Gusso-Choueri PK; Campus do Litoral Paulista, Universidade Estadual Paulista Júlio de Mesquita Filho - Unesp, Praça Infante Dom Henrique, s/n, CP 11330-900 São Vicente, SP, Brazil; Laboratório de Ecotoxicologia - Unisanta, Universidade Santa Cecília, R. Oswaldo Cruz, 277, CP 11045-907, Boqueirão, Santos, SP, Brazil., Abreu FEL; Instituto de Oceanografia, Universidade Federal do Rio Grande (FURG), Av. Italia s/n, km 8, Campus Carreiros, 96203-900 Rio Grande, RS, Brazil., Castro ÍB; Departamento de Ciências do Mar, Universidade Federal de São Paulo, Campus Baixada Santista, Rua Maria Máximo, 168, Ponta da Praia, Santos/SP, CEP: 11030-100 Santos, Brazil., Abessa DM; Campus do Litoral Paulista, Universidade Estadual Paulista Júlio de Mesquita Filho - Unesp, Praça Infante Dom Henrique, s/n, CP 11330-900 São Vicente, SP, Brazil., Choueri RB; Departamento de Ciências do Mar, Universidade Federal de São Paulo, Campus Baixada Santista, Rua Maria Máximo, 168, Ponta da Praia, Santos/SP, CEP: 11030-100 Santos, Brazil. Electronic address: rodrigo.choueri@unifesp.br. |
| المصدر: | The Science of the total environment [Sci Total Environ] 2023 May 10; Vol. 872, pp. 162215. Date of Electronic Publication: 2023 Feb 13. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0330500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1026 (Electronic) Linking ISSN: 00489697 NLM ISO Abbreviation: Sci Total Environ Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam, Elsevier. |
| مواضيع طبية MeSH: | Disinfectants* , Water Pollutants, Chemical*/toxicity, Animals ; Latin America ; Glutathione ; Aquatic Organisms ; Biomarkers ; Reproduction |
| مستخلص: | Chlorothalonil is an organochlorine compound that has long been used in agriculture. In recent years, this compound has been used as an antifouling booster biocide and its presence has been reported in marine coastal environments, especially in navigational areas. Although sediment can be a sink for chlorothalonil due to high affinity to fine particulate matter, toxicity studies with non-target marine and/or estuarine organisms is focused on waterborne exposure only. This study aimed to determine sediment-borne ecotoxicological effects of chlorothalonil on different benthic organisms of the Latin American biota using a integrative multilevel approach. Marine/estuarine organisms were exposed to sediments spiked with chlorothalonil (from 0 to 10.0 μg g -1 ) and effects at sub-individual (biochemical biomarkers in Anomalocardia flexuosa), individual (lethal effects to Tiburonella viscana and Artemia salina) and subpopulation levels (Nitokra sp. reproduction) were assessed. Increasing chlorothalonil concentrations in sediment caused increasing ecotoxicological effects in different levels of biological organisation, from biochemical to subpopulation levels. The highest exposure concentrations showed increased biomarkers of effects (lipid peroxidation and DNA damage in gills and/or digestive gland of A. flexuosa), lower fecundity and lower survival of the test organisms. GPx activity associated with LPO levels in the digestive gland suggested a response to the oxidant challenge provided by the biocide. At the lowest concentration (0.001 μg g -1 ), chlorothalonil detoxification mechanisms and defense against its oxidising action, involving GSH and glutathione-dependent enzymes (GST and GPx) were induced. At intermediate concentrations, there was a tendency of decreasing GSH levels, probably due to conjugation with chlorothalonil, which also affected the activities of the glutathione-dependent enzymes. At the highest tested concentration (10.0 μg g -1 ), chlorothalonil may have restimulated GSH synthesis in the gills of A. flexuosa, although the prooxidant activity has induced effects. This study contributes to assessing the environmental risk of chlorothalonil in sediment for non-target marine and estuarine organisms. Competing Interests: Declaration of competing interest None. (Copyright © 2023 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Antifouling; Biocide; Ecotoxicology; Genotoxicity; Oxidative stress; Pollution |
| المشرفين على المادة: | J718M71A7A (tetrachloroisophthalonitrile) GAN16C9B8O (Glutathione) 0 (Biomarkers) 0 (Disinfectants) 0 (Water Pollutants, Chemical) |
| تواريخ الأحداث: | Date Created: 20230215 Date Completed: 20230316 Latest Revision: 20230316 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.scitotenv.2023.162215 |
| PMID: | 36791867 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-1026 |
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| DOI: | 10.1016/j.scitotenv.2023.162215 |