دورية أكاديمية
Chronic unilateral inhibition of GABA synthesis in the amygdala increases specificity of conditioned fear in a discriminative fear conditioning paradigm in rats.
| العنوان: | Chronic unilateral inhibition of GABA synthesis in the amygdala increases specificity of conditioned fear in a discriminative fear conditioning paradigm in rats. |
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| المؤلفون: | El Matine R; Institute for Pharmacology and Toxicology, Otto-von-Guericke University, Magdeburg, Germany., Kreutzmann JC; Institute for Pharmacology and Toxicology, Otto-von-Guericke University, Magdeburg, Germany., Fendt M; Institute for Pharmacology and Toxicology, Otto-von-Guericke University, Magdeburg, Germany; Center for Behavioral Brain Sciences, Otto-von-Guericke University, Magdeburg, Germany. Electronic address: markus.fendt@med.ovgu.de. |
| المصدر: | Progress in neuro-psychopharmacology & biological psychiatry [Prog Neuropsychopharmacol Biol Psychiatry] 2023 Jun 08; Vol. 124, pp. 110732. Date of Electronic Publication: 2023 Feb 13. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Pergamon Press Country of Publication: England NLM ID: 8211617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-4216 (Electronic) Linking ISSN: 02785846 NLM ISO Abbreviation: Prog Neuropsychopharmacol Biol Psychiatry Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford ; New York : Pergamon Press, c1982- |
| مواضيع طبية MeSH: | Allylglycine*/pharmacology , Amygdala*, Rats ; Animals ; Fear/physiology ; Learning/physiology ; gamma-Aminobutyric Acid |
| مستخلص: | Neural activity in the amygdala is critical for fear learning. In anxiety disorder patients, bilateral hyperactivity of the amygdala can be observed. This hyperactivation is often associated with the facilitation of fear learning and/or over-generalization of conditioned fear. In contrast, hypoactivity of the amygdala, e.g. by pharmacological interventions, attenuates or blocks fear learning. To date, little is known about how neural excitability of the amygdala affects specificity or generalization of fear. Therefore, the present study utilized chronic inhibition of GABA synthesis in the amygdala to increase excitability and investigated the effect on the specificity of fear learning. In rats, unilateral cannulas aiming at the amygdala were implanted. The cannulas were connected to subcutaneously implanted osmotic mini pumps that delivered either the GABA synthesis inhibitor L-allylglycine or its inactive enantiomer D-allylglycine. Following one week of chronic GABA synthesis manipulation, the rats were submitted to a discriminative fear conditioning protocol. In addition, anxiety-like behavior in the light-dark box was measured. Our data show that chronic unilateral L-AG infusions into the amygdala improve the specificity of learned fear, support safety learning, and reduce fear generalization and anxiety. This data demonstrates that moderately increased amygdala excitability can be beneficial for the specificity of fear learning and highlights the potential application for therapeutic interventions. Competing Interests: Declaration of Competing Interest None. (Copyright © 2023 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Anxiety; Fear conditioning; Memory generalization; Memory specificity; Safety learning |
| المشرفين على المادة: | 1069-48-3 (Allylglycine) 56-12-2 (gamma-Aminobutyric Acid) |
| تواريخ الأحداث: | Date Created: 20230215 Date Completed: 20230315 Latest Revision: 20230410 |
| رمز التحديث: | 20230411 |
| DOI: | 10.1016/j.pnpbp.2023.110732 |
| PMID: | 36792003 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1878-4216 |
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| DOI: | 10.1016/j.pnpbp.2023.110732 |