دورية أكاديمية
أعرض في EDS

Impact of trigeminal and/or olfactory nerve stimulation on measures of inspiratory neural drive: Implications for breathlessness.

التفاصيل البيبلوغرافية
العنوان: Impact of trigeminal and/or olfactory nerve stimulation on measures of inspiratory neural drive: Implications for breathlessness.
المؤلفون: Aucoin R; Clinical Exercise & Respiratory Physiology Laboratory, Department of Kinesiology and Physical Education, McGill University, 475 Pine Avenue West, Montréal, Quebec H2W 1S4, Canada. Electronic address: rachelle.aucoin@mail.mcgill.ca., Lewthwaite H; College of Engineering, Science and Environment, School of Environment & Life Sciences, The University of Newcastle, 10 Chittaway Road, Ourimbah, NSW 2258, Australia., Ekström M; Department of Respiratory Medicine, Allergology and Palliative Medicine, Institution for Clinical Sciences in Lund, Lund University, SE-221 00 Lund, Sweden., von Leupoldt A; Health Psychology, University of Leuven, Tiensestraat 102 Box 3726, 3000 Leuven, Belgium., Jensen D; Clinical Exercise & Respiratory Physiology Laboratory, Department of Kinesiology and Physical Education, McGill University, 475 Pine Avenue West, Montréal, Quebec H2W 1S4, Canada; Research Institute of the McGill University Health Centre, Translational Research in Respiratory Diseases Program and Respiratory Epidemiology and Clinical Research Unit, 2155 Guy Street Suite 500, Montréal, Quebec H3H 2R9, Canada.
المصدر: Respiratory physiology & neurobiology [Respir Physiol Neurobiol] 2023 May; Vol. 311, pp. 104035. Date of Electronic Publication: 2023 Feb 13.
نوع المنشور: Systematic Review; Journal Article; Review; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 101140022 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1519 (Electronic) Linking ISSN: 15699048 NLM ISO Abbreviation: Respir Physiol Neurobiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam ; New York : Elsevier Science, c2002-
مواضيع طبية MeSH: Menthol*/pharmacology , Olfactory Nerve*, Animals ; Humans ; Dyspnea ; Nose ; Trigeminal Nerve/physiology
مستخلص: The perception of breathlessness is mechanistically linked to the awareness of increased inspiratory neural drive (IND). Stimulation of upper airway cold receptors on the trigeminal nerve (TGN) with TGN agonists such as menthol or cool air to the face/nose has been hypothesized to reduce breathlessness by decreasing IND. The aim of this systematic scoping review was to identify and summarize the results of studies in animals and humans reporting on the impact of TGN stimulation or blockade on measures of IND. Thirty-one studies were identified, including 19 in laboratory animals and 12 in human participants. Studies in laboratory animals consistently reported that as TGN activity increased, measures of IND decreased (e.g., phrenic nerve activity). In humans, stimulation of the TGN with a stream of cool air to the face/nose decreased the sensitivity of the ventilatory chemoreflex response to hypercapnia. Otherwise, TGN stimulation with menthol or cool air to the face/note had no effect on measures of IND in humans. This review provides new insight into a potential neural mechanism of breathlessness relief with selected TGN agonists.
Competing Interests: Declaration of Competing Interest All authors declare they have no conflicting interests.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
معلومات مُعتمدة: Canada CIHR
فهرسة مساهمة: Keywords: Breathlessness; Inspiratory neural drive; Nasal mucosa; Olfactory nerve; TRPM8 channels; Trigeminal nerve
المشرفين على المادة: 1490-04-6 (Menthol)
تواريخ الأحداث: Date Created: 20230215 Date Completed: 20230315 Latest Revision: 20230329
رمز التحديث: 20231215
DOI: 10.1016/j.resp.2023.104035
PMID: 36792044
قاعدة البيانات: MEDLINE
الوصف
تدمد:1878-1519
DOI:10.1016/j.resp.2023.104035