دورية أكاديمية
NMDA Receptor Activation and Ca 2+ /PKC Signaling in Nicotine-Induced GABA Transport Shift in Embryonic Chick Retina.
العنوان: | NMDA Receptor Activation and Ca 2+ /PKC Signaling in Nicotine-Induced GABA Transport Shift in Embryonic Chick Retina. |
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المؤلفون: | Souto AC; Laboratório de Neurofarmacologia, Departamento de Fisiologia e Farmacologia, Universidade Federal Fluminense, Inst Biomédico - Rua São João Batista, 187, Sala 416, Centro, Niterói, CEPRJ, 24020-005, Brazil., Tempone MH; Laboratório de Neuroquímica. IBCCF, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil., Gonçalves LAC; Laboratório de Neurofarmacologia, Departamento de Fisiologia e Farmacologia, Universidade Federal Fluminense, Inst Biomédico - Rua São João Batista, 187, Sala 416, Centro, Niterói, CEPRJ, 24020-005, Brazil., Borges-Martins VPP; Laboratório de Neurofarmacologia, Departamento de Fisiologia e Farmacologia, Universidade Federal Fluminense, Inst Biomédico - Rua São João Batista, 187, Sala 416, Centro, Niterói, CEPRJ, 24020-005, Brazil., Peixoto-Rodrigues MC; Laboratório de Neuroplasticidade, Departamento de Neurobiologia, Instituto de Biologia, Universidade Federal Fluminense, Niterói, RJ, Brazil., Damascena ACO; Laboratório de Neurofarmacologia, Departamento de Fisiologia e Farmacologia, Universidade Federal Fluminense, Inst Biomédico - Rua São João Batista, 187, Sala 416, Centro, Niterói, CEPRJ, 24020-005, Brazil., Ferraz G; Laboratório de Farmacologia Molecular, ICB, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil., Manhães AC; Laboratório de Neurofisiologia, IBRAG, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil., Castro NG; Laboratório de Farmacologia Molecular, ICB, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil., de Melo Reis RA; Laboratório de Neuroquímica. IBCCF, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil., Ventura ALM; Laboratório de Neuroquímica, Departamento de Neurobiologia, Universidade Federal Fluminense, Rio de Janeiro, RJ, Brazil., Kubrusly RCC; Laboratório de Neurofarmacologia, Departamento de Fisiologia e Farmacologia, Universidade Federal Fluminense, Inst Biomédico - Rua São João Batista, 187, Sala 416, Centro, Niterói, CEPRJ, 24020-005, Brazil. reginakubrusly@id.uff.br. |
المصدر: | Neurochemical research [Neurochem Res] 2023 Jul; Vol. 48 (7), pp. 2104-2115. Date of Electronic Publication: 2023 Feb 15. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 7613461 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-6903 (Electronic) Linking ISSN: 03643190 NLM ISO Abbreviation: Neurochem Res Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 1999- : New York, NY : Kluwer Academic/Plenum Publishers Original Publication: New York, Plenum Press |
مواضيع طبية MeSH: | Nicotine*/pharmacology , Receptors, Nicotinic*/metabolism, Animals ; Receptors, N-Methyl-D-Aspartate/metabolism ; Calcium/metabolism ; gamma-Aminobutyric Acid/metabolism ; Excitatory Amino Acid Antagonists/pharmacology ; Retina |
مستخلص: | Nicotinic receptors are present in the retina of different vertebrates, and in the chick retina, it is present during early development throughout to post-hatching. These receptors are activated by nicotine, an alkaloid with addictive and neurotransmitter release modulation properties, such as GABA signaling. Here we evaluated the mechanisms of nicotine signaling in the avian retina during the development of neuron-glia cells at a stage where synapses are peaking. Nicotine almost halved [ 3 H]-GABA uptake, reducing it by 45% whilst increasing more than two-fold [ 3 H]-GABA release in E12 embryonic chick retinas. Additionally, nicotine mediated a 33% increase in [ 3 H]-D-aspartate release. MK-801 50 μM blocked 66% of nicotine-induced [ 3 H]-GABA release and Gö 6983 100 nM prevented the nicotine-induced reduction in [ 3 H]-GABA uptake by rescuing 40% of this neurotransmitter uptake, implicating NMDAR and PKC (respectively) in the nicotinic responses. In addition, NO-711 prevented [ 3 H]-GABA uptake and release induced by nicotine. Furthermore, the relevance of calcium influx for PKC activation was evidenced through fura-2 imaging. We conclude that the shift of GABA transport mediated by nicotine promotes GABA release by inducing transporter reversal via nicotine-induced EAA release through EAATs, or by a direct effect of nicotine in activating nicotinic receptors permeable to calcium and promoting PKC pathway activation and shifting GAT-1 activity, both prompting calcium influx, and activation of the PKC pathway and shifting GAT-1 activity. (© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.) |
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فهرسة مساهمة: | Keywords: Acetylcholine; GABA; GABA transport; Glutamate; Nicotine; Nicotinic receptors |
المشرفين على المادة: | 6M3C89ZY6R (Nicotine) 0 (Receptors, N-Methyl-D-Aspartate) SY7Q814VUP (Calcium) 56-12-2 (gamma-Aminobutyric Acid) 0 (Excitatory Amino Acid Antagonists) 0 (Receptors, Nicotinic) |
تواريخ الأحداث: | Date Created: 20230215 Date Completed: 20230515 Latest Revision: 20230515 |
رمز التحديث: | 20230515 |
DOI: | 10.1007/s11064-023-03870-7 |
PMID: | 36792758 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1573-6903 |
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DOI: | 10.1007/s11064-023-03870-7 |