دورية أكاديمية
Association Between Metformin Use and Cognitive and Physical Function in Persons with HIV and Diabetes.
| العنوان: | Association Between Metformin Use and Cognitive and Physical Function in Persons with HIV and Diabetes. |
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| المؤلفون: | Masters MC; Department of Internal Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Granche J; Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA., Yang J; Institute for Social and Economic Research and Policy, Columbia University, New York, New York, USA., Overton ET; Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA., Letendre S; Department of Medicine, University of California, San Diego, La Jolla, California, USA., Koletar SL; Department of Internal Medicine, Ohio State University, Columbus, Ohio, USA., Rubin LH; Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA., Brown TT; Department of Medicine, Johns Hopkins University, Maryland, USA., Tassiopoulos K; Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA., Erlandson KM; Department of Medicine, University of Colorado, Aurora, Colorado, USA., Palella F; Department of Internal Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. |
| المصدر: | AIDS research and human retroviruses [AIDS Res Hum Retroviruses] 2023 Jun; Vol. 39 (6), pp. 302-309. Date of Electronic Publication: 2023 Mar 17. |
| نوع المنشور: | Observational Study; Journal Article; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: Mary Ann Liebert Country of Publication: United States NLM ID: 8709376 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1931-8405 (Electronic) Linking ISSN: 08892229 NLM ISO Abbreviation: AIDS Res Hum Retroviruses Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Larchmont, NY : Mary Ann Liebert Original Publication: [New York] : Mary Ann Liebert, [c1987- |
| مواضيع طبية MeSH: | Metformin*/therapeutic use , Frailty*/complications , HIV Infections*/complications , HIV Infections*/drug therapy , Diabetes Mellitus*/drug therapy, Humans ; Aged ; Aged, 80 and over ; Cross-Sectional Studies ; Cognition |
| مستخلص: | Older persons with HIV (PWH) experience high rates of cognitive impairment and frailty, and accelerated decline in physical function compared with the general population. Metformin use has been associated with beneficial effects on cognitive and physical function among older adults without HIV. The relationship between metformin use on these outcomes in PWH has not been evaluated. AIDS Clinical Trials Group (ACTG) A5322 is an observational cohort study of older PWH with annual assessments for cognition and frailty, including measures of physical function (e.g., gait speed and grip strength). Participants with diabetes who were prescribed antihyperglycemic medications were included in this analysis to evaluate the association between metformin and functional outcomes. Cross-sectional, longitudinal, and time-to-event models were used to evaluate the relationship between metformin exposure with cognitive, physical function, and frailty outcomes. Ninety-eight PWH met inclusion criteria and were included in at least one model. No significant associations between metformin use, frailty, physical, or cognitive function were noted in unadjusted or adjusted cross-sectional, longitudinal, or time-to-event models ( p > .1 for all models). This study is the first to examine the association between metformin use on functional outcomes among older PWH. Although it did not ascertain significant associations between metformin use and functional outcomes, our small sample size, restriction to persons with diabetes, and lack of randomization to metformin therapy were limitations. Larger randomized studies are needed to determine whether metformin use has beneficial effects on cognitive or physical function in PWH. Clinical Trial Registration numbers: 02570672, 04221750, 00620191, and 03733132. |
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| معلومات مُعتمدة: | UM1 AI106701 United States AI NIAID NIH HHS; P30 DK048520 United States DK NIDDK NIH HHS; UM1 AI069432 United States AI NIAID NIH HHS; UM1 AI069471 United States AI NIAID NIH HHS; K24 AI120834 United States AI NIAID NIH HHS; UM1 AI068634 United States AI NIAID NIH HHS; P30 AG059988 United States AG NIA NIH HHS; U01 HL146201 United States HL NHLBI NIH HHS; UL1 TR002384 United States TR NCATS NIH HHS; UM1 AI068636 United States AI NIAID NIH HHS; R03 AG067980 United States AG NIA NIH HHS; UM1 AI069494 United States AI NIAID NIH HHS; UM1 AI069423 United States AI NIAID NIH HHS |
| فهرسة مساهمة: | Keywords: HIV; aging; frailty; metformin; physical function |
| المشرفين على المادة: | 9100L32L2N (Metformin) |
| تواريخ الأحداث: | Date Created: 20230216 Date Completed: 20230607 Latest Revision: 20240620 |
| رمز التحديث: | 20240620 |
| مُعرف محوري في PubMed: | PMC10278023 |
| DOI: | 10.1089/AID.2022.0129 |
| PMID: | 36792952 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1931-8405 |
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| DOI: | 10.1089/AID.2022.0129 |