دورية أكاديمية
One-pot microwave synthesis of chitosan-stabilized silver nanoparticles entrapped polyethylene oxide nanofibers, with their intrinsic antibacterial and antioxidant potency for wound healing.
| العنوان: | One-pot microwave synthesis of chitosan-stabilized silver nanoparticles entrapped polyethylene oxide nanofibers, with their intrinsic antibacterial and antioxidant potency for wound healing. |
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| المؤلفون: | Aljohani MM; Department of Chemistry, Faculty of Science, University of Tabuk, 71474 Tabuk, Saudi Arabia. Electronic address: mualjohani@ut.edu.sa., Abu-Rayyan A; Department of Chemistry, Faculty of Science, Applied Science Private University, Amman 11931, Jordan., Elsayed NH; Department of Chemistry, Faculty of Science, University of Tabuk, 71474 Tabuk, Saudi Arabia; Department of Polymers and Pigments, National Research Centre, Dokki, Cairo 12311, Egypt. Electronic address: nhussein@ut.edu.sa., Alatawi FA; Department of Biology, Faculty of Science, University of Tabuk, 71474 Tabuk, Saudi Arabia. Electronic address: falatawi@ut.edu.sa., Al-Anazi M; Department of Chemistry, Faculty of Science, University of Tabuk, 71474 Tabuk, Saudi Arabia. Electronic address: mn.alenazi@ut.edu.sa., Mustafa SK; Department of Chemistry, Faculty of Science, University of Tabuk, 71474 Tabuk, Saudi Arabia. Electronic address: ssyed@ut.edu.sa., Albalawi RK; Department of Chemistry, University College Alwajh, University of Tabuk, Tabuk 71421, Saudi Arabia. Electronic address: 381007715@stu.ut.edu.sa., Abdelmonem R; Department of Industrial Pharmacy, Faculty of Pharmacy, Misr University for Science & Technology, 6th of October, Egypt. |
| المصدر: | International journal of biological macromolecules [Int J Biol Macromol] 2023 Apr 30; Vol. 235, pp. 123704. Date of Electronic Publication: 2023 Feb 17. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: Guildford, Eng., IPC Science and Technology Press. |
| مواضيع طبية MeSH: | Chitosan*/chemistry , Nanofibers*/chemistry , Metal Nanoparticles*/chemistry, Humans ; Antioxidants/pharmacology ; Staphylococcus aureus ; Silver/chemistry ; Polyethylene Glycols/chemistry ; Escherichia coli ; Microwaves ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Wound Healing |
| مستخلص: | Different physical and chemical techniques could be used to prepare chitosan/Silver nanoparticle (CHS/AgNPs) nanocomposite. The microwave heating reactor was rationally adopted as a benign tool for preparing CHS/AgNPs owing to less energy consumption and shorter time required for completing the nucleation and growth particles. UV-Vis, FTIR, and XRD, provided conclusive evidence of the AgNPs creation, while TEM micrographs elucidated that the size was spherical (20 nm). CHS/AgNPs were embedded in polyethylene oxide (PEO) nanofiber via electrospinning, and their biological properties, cytotoxicity evaluation, antioxidant, and antibacterial activity assays were investigated. The generated nanofibers have mean diameters of 130.9 ± 9.5, 168.7 ± 18.8, and 186.8 ± 8.19 nm for PEO, PEO/ CHS, and PEO/ CHS (AgNPs), respectively. Because of the tiny AgNPs particle size loaded in PEO/CHS (AgNPs) fabricated nanofiber, good antibacterial activity with ZOI against E. coli was 51.2 ± 3.2, and S. aureus was 47.2 ± 2.1 for PEO/ CHS (AgNPs) nanofibers. Non-toxicity was observed against Human Skin Fibroblast and Keratinocytes cell lines (>93.5 %), which justifies its great antibacterial potential to remove or prevent infection in wounds with fewer adverse effects. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Biomedical applications; Chitosan; Microwave reactor; Polyethylene oxide nanofibers; Silver nanoparticles |
| المشرفين على المادة: | 0 (Antioxidants) 9012-76-4 (Chitosan) 3M4G523W1G (Silver) 3WJQ0SDW1A (Polyethylene Glycols) 0 (Anti-Bacterial Agents) |
| تواريخ الأحداث: | Date Created: 20230221 Date Completed: 20230410 Latest Revision: 20230410 |
| رمز التحديث: | 20230410 |
| DOI: | 10.1016/j.ijbiomac.2023.123704 |
| PMID: | 36801282 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-0003 |
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| DOI: | 10.1016/j.ijbiomac.2023.123704 |