دورية أكاديمية
أعرض في EDS

Cannabidiol modulates contextual fear memory consolidation in animals with experimentally induced type-1 diabetes mellitus .

التفاصيل البيبلوغرافية
العنوان: Cannabidiol modulates contextual fear memory consolidation in animals with experimentally induced type-1 diabetes mellitus .
المؤلفون: Chaves YC; Department of Pharmacology, Biological Science Sector, Federal University of Paraná, Curitiba, Paraná, Brazil.; Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Raymundi AM; Department of Pharmacology, Biological Science Sector, Federal University of Paraná, Curitiba, Paraná, Brazil., Waltrick APF; Department of Pharmacology, Biological Science Sector, Federal University of Paraná, Curitiba, Paraná, Brazil., de Souza Crippa JA; Department of Neuroscience and Behavioral Sciences, Ribeirão Preto Medical School, University of São Paulo, Brazil.; National Institute of Science and Technology for Translational Medicine (INCT-TM-CNPq), Ribeirão Preto, São Paulo, Brazil., Stern CAJ; Department of Pharmacology, Biological Science Sector, Federal University of Paraná, Curitiba, Paraná, Brazil., da Cunha JM; Department of Pharmacology, Biological Science Sector, Federal University of Paraná, Curitiba, Paraná, Brazil., Zanoveli JM; Department of Pharmacology, Biological Science Sector, Federal University of Paraná, Curitiba, Paraná, Brazil.
المصدر: Acta neuropsychiatrica [Acta Neuropsychiatr] 2023 Feb 20, pp. 1-11. Date of Electronic Publication: 2023 Feb 20.
Publication Model: Ahead of Print
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Cambridge University Press Country of Publication: England NLM ID: 9612501 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1601-5215 (Electronic) Linking ISSN: 09242708 NLM ISO Abbreviation: Acta Neuropsychiatr Subsets: MEDLINE
أسماء مطبوعة: Publication: 2013- : Cambridge, United Kingdom : Cambridge University Press
Original Publication: Maarssen : Interdisciplinair Genootschap voor Biologische Psychiatrie
مستخلص: Objectives: In view of the neuroprotective characteristic of cannabidiol (CBD) and its beneficial action on aversive memory in non-diabetic animals, we aimed to investigate in animals with experimentally induced type-1 diabetes mellitus (T1DM) whether CBD treatment would be able to impair the contextual fear memory consolidation, its generalisation and whether the effect would be lasting. We also investigated the CBD effect on anxiety-like responses.
Methods: After T1DM induction, animals received single or more prolonged treatment with CBD and were submitted to the contextual fear conditioning test. As expression of activity-regulated cytoskeletal-associated (Arc) protein is necessary for memory consolidation, we evaluated its expression in the dorsal hippocampus (DH). For evaluating anxiety-related responses, animals were submitted to the elevated plus maze test (EPMT), in which the time and number of entries in the open arms were used as anxiety index.
Results: A single injection of CBD impaired the contextual fear memory consolidation and its generalisation, which was evaluated by exposing the animal in a neutral context. This single injection was able to reduce the elevated expression of Arc in the DH from these animals. Interestingly, more prolonged treatment with CBD also impaired the persistence of context-conditioned fear memory and induced an anxiolytic-like effect, as the treated group spent more time in the open arms of the EPMT.
Conclusion: CBD interferes with contextual fear memory and the dosage regimen of treatment seems to be important. Moreover, we cannot rule out the involvement of emotional aspects in these processes related to fear memory.
فهرسة مساهمة: Keywords: anxiety; arc expression; contextual conditioned fear; elevated plus maze; streptozotocin
تواريخ الأحداث: Date Created: 20230222 Latest Revision: 20230313
رمز التحديث: 20240628
DOI: 10.1017/neu.2023.13
PMID: 36805056
قاعدة البيانات: MEDLINE
الوصف
تدمد:1601-5215
DOI:10.1017/neu.2023.13