دورية أكاديمية
أعرض في EDS

Severity of COVID-19 among Residents in Aged Care Facilities in Victoria, Australia: A Retrospective Cohort Study Comparing the Delta and Omicron Epidemic Periods.

التفاصيل البيبلوغرافية
العنوان: Severity of COVID-19 among Residents in Aged Care Facilities in Victoria, Australia: A Retrospective Cohort Study Comparing the Delta and Omicron Epidemic Periods.
المؤلفون: Muleme M; Barwon South West Public Health Unit, Barwon Health, Geelong, Victoria, Australia. Electronic address: Michael.Muleme@barwonhealth.org.au., McNamara BJ; Barwon South West Public Health Unit, Barwon Health, Geelong, Victoria, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Victoria, Australia., Ampt FH; Western Public Health Unit, Western Health, St. Albans, Victoria, Australia., Baptista M; South East Public Health Unit, Monash Health, Monash, Victoria, Australia., Dittmer J; Loddon Mallee Public Health Unit, Bendigo Health, Bendigo, Victoria, Australia., Osborne A; North Eastern Public Health Unit, Austin Health, Melbourne, Victoria, Australia., Ahmed H; North Eastern Public Health Unit, Austin Health, Melbourne, Victoria, Australia., Hales G; Western Public Health Unit, Western Health, St. Albans, Victoria, Australia., Kabwe M; Loddon Mallee Public Health Unit, Bendigo Health, Bendigo, Victoria, Australia., Main S; North Eastern Public Health Unit, Austin Health, Melbourne, Victoria, Australia., Moreira C; North Eastern Public Health Unit, Austin Health, Melbourne, Victoria, Australia., Silverstein S; South East Public Health Unit, Monash Health, Monash, Victoria, Australia., Sotheran E; Western Public Health Unit, Western Health, St. Albans, Victoria, Australia., Athan E; Barwon South West Public Health Unit, Barwon Health, Geelong, Victoria, Australia., Johnson PDR; North Eastern Public Health Unit, Austin Health, Melbourne, Victoria, Australia., O'Brien DP; Barwon South West Public Health Unit, Barwon Health, Geelong, Victoria, Australia., Sullivan SG; COVID Division, Department of Health, Victoria, Australia.
المصدر: Journal of the American Medical Directors Association [J Am Med Dir Assoc] 2023 Apr; Vol. 24 (4), pp. 434-440.e5. Date of Electronic Publication: 2023 Jan 20.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 100893243 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-9375 (Electronic) Linking ISSN: 15258610 NLM ISO Abbreviation: J Am Med Dir Assoc Subsets: MEDLINE
أسماء مطبوعة: Publication: 2005- : [New York?] : Elsevier
Original Publication: Hagerstown, MD : Lippincott Williams & Wilkins, c2000-
مواضيع طبية MeSH: Pandemics* , COVID-19*/epidemiology, Male ; Humans ; Aged ; Victoria/epidemiology ; Retrospective Studies ; Disease Outbreaks
مستخلص: Objectives: During the COVID-19 pandemic, no country with widespread community transmission has avoided outbreaks or deaths in residential aged care facilities (RACFs). As RACF residents are at high risk of morbidity and mortality from COVID-19, understanding disease severity risk factors is imperative.
Design: This retrospective cohort study aimed to compare COVID-19 disease severity (hospitalization and deaths) and associated risk factors among RACF residents in Victoria, Australia, across Delta and Omicron epidemic periods.
Settings and Participants: Resident case hospitalization risk (HR) and case fatality risk (CFR) were assessed using Victorian RACFs COVID-19 outbreaks data across 2 epidemic periods; Delta, 994 resident cases linked to 86 outbreaks; and Omicron, 1882 resident cases linked to 209 outbreaks.
Methods: Adjusting for outbreak-level clustering, age, sex, up-to-date vaccination status, and time since last vaccination, the odds of hospitalization and death were compared using mixed effects logistic regression.
Results: The HR and CFR was lower during the Omicron period compared with the Delta period [HR 8.2% vs 24.6%, odds ratio (OR) 0.17, 95% CI 0.11-0.26, and CFR: 11.4% vs 18.7%, OR 0.40, 95% CI 0.28-0.56]. During both periods, males had higher odds of hospitalization and odds of death; being up to date with vaccination reduced odds of hospitalization by 40% (excluding nonemergency patient transfers) and odds of death by 43%; and for each month since last vaccination, odds of hospitalization increased by 9% and odds of death by 16%.
Conclusions and Implications: This study provides empirical evidence of lower COVID-19 severity among RACF residents in the Omicron period and highlights the importance of up-to-date and timely vaccination to reduce disease severity in this cohort.
(Copyright © 2023 AMDA – The Society for Post-Acute and Long-Term Care Medicine. All rights reserved.)
References: Lancet. 2022 Mar 5;399(10328):924-944. (PMID: 35202601)
BMC Infect Dis. 2021 Jul 27;21(1):710. (PMID: 34315427)
MMWR Morb Mortal Wkly Rep. 2022 Feb 18;71(7):255-263. (PMID: 35176007)
Viruses. 2020 Dec 10;12(12):. (PMID: 33322035)
JAMA. 2022 Feb 8;327(6):583-584. (PMID: 34967859)
JAMA. 2022 Jan 25;327(4):319-320. (PMID: 34935863)
Lancet Healthy Longev. 2022 May;3(5):e347-e355. (PMID: 35531432)
Lancet Respir Med. 2022 Jul;10(7):689-699. (PMID: 35468336)
Commun Dis Intell (2018). 2020 Nov 24;44:. (PMID: 33357173)
Nature. 2022 Mar;603(7902):700-705. (PMID: 35104835)
N Engl J Med. 2021 Aug 12;385(7):585-594. (PMID: 34289274)
BMJ. 2022 Aug 2;378:e070695. (PMID: 35918098)
Euro Surveill. 2022 Jan;27(4):. (PMID: 35086614)
Clin Kidney J. 2021 Oct 12;15(2):226-234. (PMID: 35140934)
Lancet Public Health. 2022 May;7(5):e427-e436. (PMID: 35461593)
Lancet. 2022 Apr 2;399(10332):1303-1312. (PMID: 35305296)
فهرسة مساهمة: Keywords: COVID-19 severity outcomes; residential aged care facilities; vaccination
تواريخ الأحداث: Date Created: 20230222 Date Completed: 20230404 Latest Revision: 20230516
رمز التحديث: 20230516
مُعرف محوري في PubMed: PMC9852301
DOI: 10.1016/j.jamda.2023.01.006
PMID: 36806486
قاعدة البيانات: MEDLINE
الوصف
تدمد:1538-9375
DOI:10.1016/j.jamda.2023.01.006