دورية أكاديمية
Utility of Elective Neck Dissection in Clinically Node-Negative Parotid Malignancy.
| العنوان: | Utility of Elective Neck Dissection in Clinically Node-Negative Parotid Malignancy. |
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| المؤلفون: | Vedula S; Department of Otolaryngology-Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA., Shah YS; Department of Otolaryngology-Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA., Barinsky GL; Department of Otolaryngology-Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA., Baredes S; Department of Otolaryngology-Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA.; Department of Neurological Surgery, Center for Skull Base and Pituitary Surgery, Rutgers New Jersey Medical School, Neurological Institute of New Jersey, Newark, New Jersey, USA., Park RCW; Department of Otolaryngology-Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA. |
| المصدر: | Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery [Otolaryngol Head Neck Surg] 2023 Oct; Vol. 169 (4), pp. 917-927. Date of Electronic Publication: 2023 Feb 17. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley Country of Publication: England NLM ID: 8508176 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6817 (Electronic) Linking ISSN: 01945998 NLM ISO Abbreviation: Otolaryngol Head Neck Surg Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2023- : [Oxford] : Wiley Original Publication: [Rochester, Minn.] : The Academy, [c1981- |
| مواضيع طبية MeSH: | Parotid Neoplasms*/pathology , Carcinoma, Squamous Cell*/pathology, Humans ; Neck Dissection ; Retrospective Studies ; Neoplasm Staging ; Lymphatic Metastasis |
| مستخلص: | Objective: We sought to investigate the utility of elective neck dissection (END) in clinically node-negative parotid malignancy through the evaluation of factors that are associated with receiving END and survival analysis of patients who received END. Study Design: Retrospective cohort database study. Setting: The National Cancer Database (NCDB). Methods: The NCDB was used to extract patients with clinically node-negative parotid malignancy. END was defined as having 5 or more lymph nodes examined pathologically, as previously defined in the literature. Univariate and multivariate analyses were used to compare predictors of receiving END, rates of occult metastasis, and survival. Results: Of the 9405 included patients, 3396 (36.1%) underwent an END. END was most frequently performed for squamous cell carcinoma (SCC) and salivary duct histology. All other histologies were significantly less likely to undergo END compared to SCC (p < .05). Salivary ductal carcinoma and adenocarcinoma had the greatest rates of occult node disease (39.8% and 30.0%, respectively), followed by SCC (29.8%). Kaplan-Meier survival analysis showed a statistically significant increase in 5-year overall survival in patients who received END with poorly differentiated mucoepidermoid (56.2% vs 48.5%, p = .004) along with moderately and poorly differentiated SCC (43.2% vs 34.9%, p = .002; 48.9% vs 36.2%, p < .001, respectively). Conclusion: Histological classification is a benchmark for determining which patients should receive an END. We demonstrated an increase in overall survival in patients who undergo END with poorly differentiated tumors of mucoepidermoid and SCC histology. As such, histology should be considered along with clinical T-stage and rate of occult nodal metastasis to determine eligibility for END. (© 2023 American Academy of Otolaryngology-Head and Neck Surgery Foundation.) |
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| فهرسة مساهمة: | Keywords: National Cancer Database; elective neck dissection; head and neck cancer; occult disease; parotid malignancy |
| تواريخ الأحداث: | Date Created: 20230222 Date Completed: 20230925 Latest Revision: 20231007 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1002/ohn.264 |
| PMID: | 36807904 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1097-6817 |
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| DOI: | 10.1002/ohn.264 |