دورية أكاديمية
Context-dependent effects of the CB1 receptor antagonist rimonabant on morphine-induced behavioral sensitization in female mice.
| العنوان: | Context-dependent effects of the CB1 receptor antagonist rimonabant on morphine-induced behavioral sensitization in female mice. |
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| المؤلفون: | Marinho EAV; Department of Health Sciences, Universidade Estadual de Santa Cruz, Ilhéus, BA, Brazil.; Department of Pharmacology, Universidade Federal de São Paulo, São Paulo, SP, Brazil., Oliveira-Lima AJ; Department of Health Sciences, Universidade Estadual de Santa Cruz, Ilhéus, BA, Brazil.; Department of Pharmacology, Universidade Federal de São Paulo, São Paulo, SP, Brazil., Reis HS; Department of Health Sciences, Universidade Estadual de Santa Cruz, Ilhéus, BA, Brazil., Santos-Baldaia R; Department of Pharmacology, Universidade Federal de São Paulo, São Paulo, SP, Brazil., Wuo-Silva R; Department of Pharmacology, Universidade Federal de São Paulo, São Paulo, SP, Brazil., Hollais AW; Department of Pharmacology, Universidade Federal de São Paulo, São Paulo, SP, Brazil., Yokoyama TS; Department of Pharmacology, Universidade Federal de São Paulo, São Paulo, SP, Brazil., Frussa-Filho R; Department of Pharmacology, Universidade Federal de São Paulo, São Paulo, SP, Brazil., Berro LF; Department of Health Sciences, Universidade Estadual de Santa Cruz, Ilhéus, BA, Brazil.; Department of Pharmacology, Universidade Federal de São Paulo, São Paulo, SP, Brazil.; Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, United States. |
| المصدر: | Frontiers in pharmacology [Front Pharmacol] 2023 Feb 06; Vol. 14, pp. 1100527. Date of Electronic Publication: 2023 Feb 06 (Print Publication: 2023). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [Lausanne : Frontiers Media] |
| مستخلص: | Introduction: The endocannabinoid system has been implicated in the neurobiology of opioid use disorder. While the CB1 receptor antagonist rimonabant has been shown to block some of the behavioral effects of opioids, studies suggest that the treatment environment (i.e., receiving treatment in the drug-associated environment, and/or novelty) can influence its effects. In the present study, we investigated the role of the treatment environment in the effects of rimonabant on the expression of morphine-induced behavioral sensitization. Methods: Adult female Swiss mice were submitted to a behavioral sensitization protocol, during which they received morphine (20 mg/kg, i.p.) in the open-field apparatus, and were subsequently treated with vehicle or rimonabant (1 or 10 mg/kg, i.p.) either in the open-field, in the home-cage or in an activity box (novel environment). The expression of conditioned locomotion (increased locomotor activity in the open-field apparatus in the absence of morphine) and of morphine-induced behavioral sensitization (increased locomotor activity in animals sensitized to morphine) was evaluated during asubsequent saline and morphine challenge, respectively. Results: Animals treated with morphine expressed behavioral sensitization, showing a significant increase in locomotor activity over time. Animals sensitized to morphine and treated with vehicle in the home-cage expressed conditioned locomotion, an effect that was blocked by home-cage treatment with rimonabant. During a saline challenge, only animals sensitized to morphine and treated with saline in the home-cage expressed morphine-induced conditioned locomotion. All morphine-treated animals that received saline during the treatment phase (control groups) expressed behavioral sensitization during the morphine challenge. Treatment with rimonabant in the open-field and in the activity box, but not in the home-cage, blocked the expression of morphine-induced behavioral sensitization. Discussion: Our findings suggest that CB1 receptor antagonism can modulate conditioned responses to morphine even when administered in the home-cage. However, exposure to the drug-associated environment or to a novel environment is necessary for the expression of rimonabant's effects on morphine-induced behavioral sensitization during a morphine challenge. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Marinho, Oliveira-Lima, Reis, Santos-Baldaia, Wuo-Silva, Hollais, Yokoyama, Frussa-Filho and Berro.) |
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| فهرسة مساهمة: | Keywords: CB1 receptor; context; environment; mice; morphine; rimonabant |
| تواريخ الأحداث: | Date Created: 20230223 Latest Revision: 20230224 |
| رمز التحديث: | 20230224 |
| مُعرف محوري في PubMed: | PMC9939462 |
| DOI: | 10.3389/fphar.2023.1100527 |
| PMID: | 36814501 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1663-9812 |
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| DOI: | 10.3389/fphar.2023.1100527 |