دورية أكاديمية
Therapeutic Effects of Myriocin in Experimental Alcohol-Related Neurobehavioral Dysfunction and Frontal Lobe White Matter Biochemical Pathology.
| العنوان: | Therapeutic Effects of Myriocin in Experimental Alcohol-Related Neurobehavioral Dysfunction and Frontal Lobe White Matter Biochemical Pathology. |
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| المؤلفون: | Homans C; Biotechnology Graduate Program, Brown University, Providence, RI, USA., Yalcin EB; Department of Pathology and Laboratory Medicine, Warren Alpert Medical School of Brown University, Providence, RI, USA.; Liver Research Center, Department of Medicine, Rhode Island Hospital, Providence, RI, USA., Tong M; Liver Research Center, Department of Medicine, Rhode Island Hospital, Providence, RI, USA., Gallucci G; Liver Research Center, Department of Medicine, Rhode Island Hospital, Providence, RI, USA., Bautista D; Warren Alpert Medical School of Brown University, Providence, RI, USA.; Brown University, Providence, RI, USA., Moriel N; Warren Alpert Medical School of Brown University, Providence, RI, USA., de la Monte S; Department of Pathology and Laboratory Medicine, Warren Alpert Medical School of Brown University, Providence, RI, USA.; Warren Alpert Medical School of Brown University, Providence, RI, USA.; Department of Pathology and Laboratory Medicine, Rhode Island Hospital, Women and Infants Hospital of Rhode Island, Providence VA Medical Center, Providence, RI, USA. |
| المصدر: | Journal of behavioral and brain science [J Behav Brain Sci] 2022 Feb; Vol. 12 (2), pp. 23-42. Date of Electronic Publication: 2022 Feb 10. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Scientific Research Pub Country of Publication: United States NLM ID: 101600257 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2160-5866 (Print) Linking ISSN: 21605866 NLM ISO Abbreviation: J Behav Brain Sci Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [Irvine, Calif.] : Scientific Research Pub. |
| مستخلص: | Background & Objective: Chronic excessive alcohol consumption causes white matter degeneration with myelin loss and impaired neuronal conductivity. Subsequent rarefaction of myelin accounts for the sustained deficits in cognition, learning, and memory. Correspondingly, chronic heavy or repeated binge alcohol exposures in humans and experimental models alter myelin lipid composition leading to build-up of ceramides which can be neurotoxic and broadly inhibitory to brain functions. Methods: This study examined the effects of chronic + binge alcohol exposures (8 weeks) and intervention with myriocin, a ceramide inhibitor, on neurobehavioral functions (Open Field, Novel Object Recognition, and Morris Water Maze tests) and frontal lobe white matter myelin lipid biochemical pathology in an adult Long-Evans rat model. Results: The ethanol-exposed group had significant deficits in executive functions with increased indices of anxiety and impairments in spatial learning acquisition. Myriocin partially remediated these effects of ethanol while not impacting behavior in the control group. Ethanol-fed rats had significantly smaller brains with broadly reduced expression of sulfatides and reduced expression of two of the three sphingomyelins detected in frontal white matter. Myriocin partially resolved these effects corresponding with improvements in neurobehavioral function. Conclusion: Therapeutic strategies that support cerebral white matter myelin expression of sulfatide and sphingomyelin may help remediate cognitive-behavioral dysfunction following chronic heavy alcohol consumption in humans. Competing Interests: Conflicts of Interest The authors declare no conflicts of interest regarding the publication of this paper. |
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| معلومات مُعتمدة: | R01 AA011431 United States AA NIAAA NIH HHS; R01 AA028408 United States AA NIAAA NIH HHS |
| فهرسة مساهمة: | Keywords: Adolescence; Alcohol; Behavior; Binge Drinking; Brain Atrophy; Myriocin; Neurodegeneration; Rat; Sulfatide; White Matter |
| تواريخ الأحداث: | Date Created: 20230223 Latest Revision: 20230301 |
| رمز التحديث: | 20230301 |
| مُعرف محوري في PubMed: | PMC9942847 |
| DOI: | 10.4236/jbbs.2022.122003 |
| PMID: | 36815096 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2160-5866 |
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| DOI: | 10.4236/jbbs.2022.122003 |