دورية أكاديمية
Synthesis of non-symmetric N -benzylbispidinol amides and study of their inhibitory activity against the main protease of the SARS-CoV-2 virus.
| العنوان: | Synthesis of non-symmetric N -benzylbispidinol amides and study of their inhibitory activity against the main protease of the SARS-CoV-2 virus. |
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| المؤلفون: | Dalinger AI; Lomonosov Moscow State University, Build. 3, 1 Leninskie Gory, 119991 Moscow, Russian Federation., Baev DS; N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9 prosp. Acad. Lavrentieva, 630090 Novosibirsk, Russian Federation., Yarovaya OI; N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9 prosp. Acad. Lavrentieva, 630090 Novosibirsk, Russian Federation., Chirkova VY; Altai State University, 61 prosp. Lenina, 656049 Barnaul, Russian Federation., Sharlaeva EA; Altai State University, 61 prosp. Lenina, 656049 Barnaul, Russian Federation., Belenkaya SV; Novosibirsk State University, 2 ul. Pirogova, 630090 Novosibirsk, Russian Federation.; Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, State Research Center of Virology and Biotechnology VECTOR, 630559 Koltsovo, Novosibirsk region, Russian Federation., Shcherbakov DN; Altai State University, 61 prosp. Lenina, 656049 Barnaul, Russian Federation.; Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, State Research Center of Virology and Biotechnology VECTOR, 630559 Koltsovo, Novosibirsk region, Russian Federation., Salakhutdinov NF; N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9 prosp. Acad. Lavrentieva, 630090 Novosibirsk, Russian Federation., Vatsadze SZ; N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991 Moscow, Russian Federation. |
| المصدر: | Russian chemical bulletin = Izvestiia Akademii nauk. Seriia khimicheskaia [Russ Chem Bull] 2023; Vol. 72 (1), pp. 239-247. Date of Electronic Publication: 2023 Feb 14. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer US Country of Publication: United States NLM ID: 100912060 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1066-5285 (Print) Linking ISSN: 10665285 NLM ISO Abbreviation: Russ Chem Bull Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: New York : Springer US Original Publication: New York : Consultants Bureau, c1993- |
| مستخلص: | Based on the data obtained by molecular modeling of the non-covalent interaction of non-symmetric N -benzylbispidin-9-ol amides with the active site of the main protease 3CLpro of the SARS-CoV-2 virus, a series of compounds was synthesized, and their inhibitory activity against 3CLpro was studied and compared with that of the known inhibitor ML188 (IC (© Springer Science+Business Media LLC 2023.) |
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| فهرسة مساهمة: | Keywords: 3CLpro; SARS-CoV-2; amides; bispidine; inhibition; main viral protease; molecular docking |
| تواريخ الأحداث: | Date Created: 20230223 Latest Revision: 20230224 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC9926410 |
| DOI: | 10.1007/s11172-023-3729-x |
| PMID: | 36817558 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1066-5285 |
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| DOI: | 10.1007/s11172-023-3729-x |