دورية أكاديمية
PENTRAXIN 3 LEVELS CORRELATE WELL WITH DISEASE SEVERITY AT ADMISSION IN COVID-19 PATIENTS.
| العنوان: | PENTRAXIN 3 LEVELS CORRELATE WELL WITH DISEASE SEVERITY AT ADMISSION IN COVID-19 PATIENTS. |
|---|---|
| المؤلفون: | Işık ME; University of Health Sciences, Koşuyolu High Specialization Research and Training Hospital, Department of Infectious Diseases, Istanbul, Turkey., Korkusuz R; University of Health Sciences, Bakırköy Dr. Sadi Konuk Research and Training Hospital, Department of Infectious Diseases, Istanbul, Turkey., Şahingöz GE; University of Health Sciences, Bakırköy Dr. Sadi Konuk Research and Training Hospital, Department of Internal Medicine, Istanbul, Turkey., Işık AC; University of Health Sciences, Kartal Dr. Lütfi Kırdar City Hospital, Department of Internal Medicine, Istanbul, Turkey., Karagöz A; University of Health Sciences, Koşuyolu High Specialization Research and Training Hospital, Department of Cardiology, Istanbul, Turkey., Işıksaçan N; University of Health Sciences, Bakırköy Dr. Sadi Konuk Research and Training Hospital, Department of Biochemistry, Istanbul, Turkey., Taş SK; University of Health Sciences, Department of Immunology, Istanbul, Turkey., Yaşar KK; University of Health Sciences, Bakırköy Dr. Sadi Konuk Research and Training Hospital, Department of Infectious Diseases, Istanbul, Turkey. |
| المصدر: | Acta clinica Croatica [Acta Clin Croat] 2022 Aug; Vol. 61 (2), pp. 303-310. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Sestre Milosrdnice University Hospital, Institute for Clinical Medical Research Country of Publication: Croatia NLM ID: 9425483 Publication Model: Print Cited Medium: Internet ISSN: 1333-9451 (Electronic) Linking ISSN: 03539466 NLM ISO Abbreviation: Acta Clin Croat Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Sept. 1995- : Zagreb : Sestre Milosrdnice University Hospital, Institute for Clinical Medical Research, Original Publication: Zagreb : Klinička bolnica "Sestre milosrdnice" : Institut za kliničko-medicinska istrazivanja u Zagrebu, 1991- |
| مواضيع طبية MeSH: | Endothelial Cells* , COVID-19*, Humans ; Biomarkers ; SARS-CoV-2 ; C-Reactive Protein ; Patient Acuity |
| مستخلص: | Pentraxin 3 (PTX3), a long pentraxin, is not only released from dendritic cells and neutrophils but also from epithelial and endothelial cells such as alveolar epithelium. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) initially activates the innate immune system, causing a complex immune response. Clinical and experimental studies suggest that PTX3, a locally and systemically secreted marker, can be used as a predictor of the severity and mortality in respiratory infections. In the current study, serum PTX3 levels in patients hospitalized with COVID-19 were found to be significantly increased at admission and showed significant association with the disease severity. |
| References: | Nat Immunol. 2021 Jan;22(1):19-24. (PMID: 33208929) J Infect. 2021 Apr;82(4):84-123. (PMID: 33147434) Front Immunol. 2019 Dec 03;10:2817. (PMID: 31849985) Acta Clin Croat. 2021 Mar;60(1):103-114. (PMID: 34588729) Immunol Rev. 2009 Jan;227(1):75-86. (PMID: 19120477) Clin Immunol. 2020 Jun;215:108448. (PMID: 32353634) Medicine (Baltimore). 2020 Apr;99(14):e19532. (PMID: 32243370) Lancet Respir Med. 2020 Jun;8(6):544-546. (PMID: 32380023) J Clin Immunol. 2008 Jan;28(1):1-13. (PMID: 17828584) Front Immunol. 2019 Apr 12;10:794. (PMID: 31031772) Acta Clin Croat. 2020 Dec;59(4):740-744. (PMID: 34285445) |
| فهرسة مساهمة: | Keywords: C-reactive protein; COVID-19; Innate immunity; Pentraxin 3; SARS-CoV-2 |
| المشرفين على المادة: | 148591-49-5 (PTX3 protein) 0 (Biomarkers) 9007-41-4 (C-Reactive Protein) |
| تواريخ الأحداث: | Date Created: 20230223 Date Completed: 20230227 Latest Revision: 20230227 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC9934037 |
| DOI: | 10.20471/acc.2022.61.02.17 |
| PMID: | 36818928 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1333-9451 |
|---|---|
| DOI: | 10.20471/acc.2022.61.02.17 |