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Morvan's Syndrome: The Importance of Knowing Different Risk-Associated Phenotypes and Antibodies in Identifying the Correct Underlying Tumor.

التفاصيل البيبلوغرافية
العنوان: Morvan's Syndrome: The Importance of Knowing Different Risk-Associated Phenotypes and Antibodies in Identifying the Correct Underlying Tumor.
المؤلفون: Ramalho AR; Internal Medicine Service, Centro Hospitalar e Universitário de Coimbra, Coimbra, PRT., Abreu Fernandes J; Internal Medicine Service, Centro Hospitalar e Universitário de Coimbra, Coimbra, PRT., Magalhães JT; Internal Medicine Service, Centro Hospitalar e Universitário de Coimbra, Coimbra, PRT., Rocha MJ; Internal Medicine Service, Centro Hospitalar e Universitário de Coimbra, Coimbra, PRT., Cunha G; Oncology, Instituto Português de Oncologia de Coimbra, Coimbra, PRT., Petrova M; Internal Medicine Service, Centro Hospitalar e Universitário de Coimbra, Coimbra, PRT., Moura J; Internal Medicine Service, Centro Hospitalar e Universitário de Coimbra, Coimbra, PRT., Santos L; Internal Medicine Service, Centro Hospitalar e Universitário de Coimbra, Coimbra, PRT.
المصدر: Cureus [Cureus] 2023 Jan 16; Vol. 15 (1), pp. e33841. Date of Electronic Publication: 2023 Jan 16 (Print Publication: 2023).
نوع المنشور: Case Reports
اللغة: English
بيانات الدورية: Publisher: Cureus, Inc Country of Publication: United States NLM ID: 101596737 Publication Model: eCollection Cited Medium: Print ISSN: 2168-8184 (Print) Linking ISSN: 21688184 NLM ISO Abbreviation: Cureus Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Palo Alto, CA : Cureus, Inc.
مستخلص: Paraneoplastic neurologic syndromes (PNS) are neurologic disorders that can affect any part of the nervous system, occur in association with cancer, and have an immune-mediated mechanism that produces direct damage to the neural tissue. Neurological symptoms frequently precede, in months to years, the symptoms directly attributed to the primary tumor, requiring a high clinical suspicion for adequate investigation. We report the case of a man in his early 80s admitted for an altered level of consciousness, alternating between periods with stupor and drowsiness, short-term waking states and psychomotor agitation, respiratory failure and dysautonomia, resembling a Morvan's syndrome. Anti-leucine-rich glioma-inactivated 1 and anti-contactin-associated protein-like 2 antibodies were both positive and, after exclusion of infectious and autoimmune systemic causes, the possibility of PNS was raised. Screening for the primary tumor was pursued, and an 18F-fluorodeoxyglucose (18F-FDG)/PET showed only an intensely hypermetabolic, apparent parietal thickening of the lower rectum. Due to the frequent association of Morvan's syndrome to thymoma, a review of the CT of the thorax images was requested and a mediastinal image with features of thymoma was identified. PNS treatment and prognosis depend on finding and treating the underlying tumor, with benefits in both resolution of neurological symptoms and in the prognosis of the underlying tumor itself. Therefore, clinicians should be aware of this frequent but underdiagnosed and underreported condition, in order to improve the chances of better outcomes.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright © 2023, Ramalho et al.)
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فهرسة مساهمة: Keywords: caspr2; lgi1; morvan’s syndrome; paraneoplastic neurologic syndromes; thymoma
تواريخ الأحداث: Date Created: 20230223 Latest Revision: 20230224
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9931382
DOI: 10.7759/cureus.33841
PMID: 36819439
قاعدة البيانات: MEDLINE
الوصف
تدمد:2168-8184
DOI:10.7759/cureus.33841