دورية أكاديمية
Characterization and quantitation of busulfan DNA adducts in the blood of patients receiving busulfan therapy.
العنوان: | Characterization and quantitation of busulfan DNA adducts in the blood of patients receiving busulfan therapy. |
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المؤلفون: | Guidolin V; Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.; School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA., Li Y; Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.; Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN 55455, USA., Jacobs FC; Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.; School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA., MacMillan ML; Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.; Blood and Marrow Transplantation & Cellular Therapy Program, Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA., Villalta PW; Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.; Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN 55455, USA., Hecht SS; Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA., Balbo S; Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.; School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA. |
المصدر: | Molecular therapy oncolytics [Mol Ther Oncolytics] 2023 Jan 20; Vol. 28, pp. 197-210. Date of Electronic Publication: 2023 Jan 20 (Print Publication: 2023). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 101666776 Publication Model: eCollection Cited Medium: Print ISSN: 2372-7705 (Print) Linking ISSN: 23727705 NLM ISO Abbreviation: Mol Ther Oncolytics Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Publication: 2017- : Cambridge, MA : Cell Press Original Publication: New York, NY : Nature Publishing Group, [2014]-[2023] |
مستخلص: | DNA alkylating drugs have been used as cancer chemotherapy with variable outcomes. The establishment of predictive biomarkers to identify patients who will effectively respond to treatment would allow for the development of personalized therapies. As the degree of interaction of alkylating drug with DNA plays a key role in their mechanism of action, our hypothesis is that the measurement of the DNA adducts formed by alkylating drugs could be used to inform patient stratification. Beginning with busulfan, we took advantage of our DNA adductomic approach to characterize DNA adducts formed by reacting busulfan with calf-thymus DNA. Samples collected from six patients undergoing busulfan-based chemotherapy prior to allogeneic hematopoietic cell transplantation were analyzed for the presence of busulfan-derived DNA adducts. Among the 15 adducts detected in vitro , 12 were observed in the patient blood confirming the presence of a large profile of DNA adducts in vivo . Two of the detected adducts were structurally confirmed by comparison with synthetic standards and quantified in patients. These data confirm our ability to comprehensively characterize busulfan-derived DNA damage and set the stage for the development of methods to support personalized chemotherapy. Competing Interests: The authors declare no competing interests. (© 2023 The Authors.) |
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معلومات مُعتمدة: | P30 CA077598 United States CA NCI NIH HHS; R50 CA211256 United States CA NCI NIH HHS |
فهرسة مساهمة: | Keywords: DNA adduct; alkylating agents; biomarker; busulfan; mass spectrometry; precision medicine |
تواريخ الأحداث: | Date Created: 20230223 Latest Revision: 20230523 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC9938526 |
DOI: | 10.1016/j.omto.2023.01.005 |
PMID: | 36820303 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2372-7705 |
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DOI: | 10.1016/j.omto.2023.01.005 |