دورية أكاديمية
أعرض في EDS

Jaboticaba (Myrciaria cauliflora) Fruit Extract Suppressed Aberrant Crypt Formation in 1,2-Dimetylhydrazine-Induced Rats.

التفاصيل البيبلوغرافية
العنوان: Jaboticaba (Myrciaria cauliflora) Fruit Extract Suppressed Aberrant Crypt Formation in 1,2-Dimetylhydrazine-Induced Rats.
المؤلفون: Ardanareswari K; Department of Food and Nutrition, Providence University, No. 200, Section 7, Taiwan Blvd, Shalu District, Taichung City, 43301, Republic of China (Taiwan).; Department of Food Technology, Soegijapranata Catholic University, Semarang, Indonesia., Lowisia W; Department of Food and Nutrition, Providence University, No. 200, Section 7, Taiwan Blvd, Shalu District, Taichung City, 43301, Republic of China (Taiwan).; Department of Food Technology, Soegijapranata Catholic University, Semarang, Indonesia., Soedarini B; Department of Food Technology, Soegijapranata Catholic University, Semarang, Indonesia., Liao JW; Graduate Institute of Veterinary Pathobiology, National Chung-Hsing University, Taichung City, Republic of China (Taiwan)., Chung YC; Department of Food and Nutrition, Providence University, No. 200, Section 7, Taiwan Blvd, Shalu District, Taichung City, 43301, Republic of China (Taiwan). ycchun@pu.edu.tw.
المصدر: Plant foods for human nutrition (Dordrecht, Netherlands) [Plant Foods Hum Nutr] 2023 Jun; Vol. 78 (2), pp. 286-291. Date of Electronic Publication: 2023 Feb 23.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Kluwer Academic Country of Publication: Netherlands NLM ID: 8803554 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-9104 (Electronic) Linking ISSN: 09219668 NLM ISO Abbreviation: Plant Foods Hum Nutr Subsets: MEDLINE
أسماء مطبوعة: Publication: Dordrecht : Kluwer Academic
Original Publication: [Dordrecht] : Martinus Nijhoff, c1987-
مواضيع طبية MeSH: Colorectal Neoplasms*/prevention & control , Colonic Neoplasms* , Aberrant Crypt Foci*, Rats ; Animals ; Fruit ; Gallic Acid ; Butyrates ; 1,2-Dimethylhydrazine/toxicity
مستخلص: Early intervention can significantly improve the colorectal cancer survival rate. Foods rich in phenolic compounds, such as jaboticaba (Myrciaria cauliflora), may prevent tumorigenesis. We investigated the effectivity of jaboticaba whole fruit ethanolic extract (FEX) in suppressing aberrant crypt foci (ACF), the earliest lesion of colorectal cancer (CRC), in 1,2-dimethylhydrazine (DMH)-induced rats and the underlying mechanisms related to the gut microbiota composition and short chain fatty acid (SCFA). This study was approved by the Institutional Animal Care and Use Committee (IACUC) of Providence University (Trial Registration Number 20180419A01, registration date: 22 December 2018). The FEX contains gallic acid and an especially high ellagic acid concentration of 54.41 ± 1.80 and 209.79 ± 2.49 mg/100 g FEX. The highest total ACF number (150.00 ± 43.86) was recorded in the DMH control (D) group. After 56 days of oral FEX treatment, the total ACF number in the low FEX dosage (DL) group was significantly lower compared to the D group (p < 0.05). The large-sized ACF (> 5 foci), which has a higher probability of progressing to later stage, was significantly decreased in the high FEX dosage (DH) group. The 16s rDNA metagenomic sequencing of the cecal material revealed that the CRC biomarker Lachnoclostridium was significantly suppressed in the DH group (p < 0.05), whereas some SCFA-producing taxa and the cecal butyrate concentration were significantly elevated in the DL and DH groups (p < 0.05). This study demonstrated the potential of jaboticaba whole fruit in CRC prevention, especially in the initial stage, by shifting gut microbiota composition and improving cecal butyrate level.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
References: Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71(3):209–249. https://doi.org/10.3322/caac.21660. (PMID: 10.3322/caac.2166033538338)
Siegel RL, Miller KD, Fuchs HE, Jemal A (2022) Cancer statistics, 2022. CA Cancer J Clin 72(1):7–33. https://doi.org/10.3322/caac.21708. (PMID: 10.3322/caac.2170835020204)
Society AC (2022) Cancer facts & Fig. 2022. American Cancer Society. https://www.cancer.org/research/cancer-facts-statistics/all-cancer-facts-figures/cancer-facts-figures-2022.html . Accessed 13 October 2022.
Bird RP (1995) Role of aberrant crypt foci in understanding the pathogenesis of colon cancer. Cancer Lett 93(1):55–71. https://doi.org/10.1016/0304-3835(95)03788-X. (PMID: 10.1016/0304-3835(95)03788-X7600544)
Takayama T, Katsuki S, Takahashi Y, Ohi M, Nojiri S, Sakamaki S, Kato J, Kogawa K, Miyake H, Niitsu Y (1998) Aberrant crypt foci of the colon as precursors of adenoma and cancer. N Engl J Med 339(18):1277–1284. https://doi.org/10.1056/NEJM199810293391803. (PMID: 10.1056/NEJM1998102933918039791143)
Perše M, Cerar A (2010) Morphological and molecular alterations in 1,2-dimethylhydrazine and azoxymethane induced colon carcinogenesis in rats. J Biomed Biotechnol 2011. https://doi.org/10.1155/2011/473964.
Rawla P, Sunkara T, Barsouk A (2019) Epidemiology of colorectal cancer: incidence, mortality, survival, and risk factors. Gastroenterol Rev 14(2):89–103. https://doi.org/10.5114/pg.2018.81072. (PMID: 10.5114/pg.2018.81072)
Stone WL, Krishnan K, Campbell SE, Palau VE (2014) The role of antioxidants and pro-oxidants in colon cancer. World J Gastrointest Oncol 6(3):55. https://doi.org/10.4251/wjgo.v6.i3.55. (PMID: 10.4251/wjgo.v6.i3.55246537953955779)
Salomão LC, de Siqueira DL, Aquino CF, de Lins LC (2018) Jabuticaba—Myrciaria spp. Exotic fruits. Elsevier, pp 237–244.
Inada KOP, Oliveira AA, Revorêdo TB, Martins ABN, Lacerda ECQ, Freire AS, Braz BF, Santelli RE, Torres AG, Perrone D (2015) Screening of the chemical composition and occurring antioxidants in jabuticaba (Myrciaria jaboticaba) and jussara (Euterpe edulis) fruits and their fractions. J Funct Foods 17:422–433. https://doi.org/10.1016/j.jff.2015.06.002. (PMID: 10.1016/j.jff.2015.06.002)
Reynertson KA, Wallace AM, Adachi S, Gil RR, Yang H, Basile MJ, D’Armiento J, Weinstein IB, Kennelly EJ (2006) Bioactive depsides and anthocyanins from jaboticaba (Myrciaria cauliflora). J Nat Prod 69(8):1228–1230. https://doi.org/10.1021/np0600999. (PMID: 10.1021/np060099916933884)
Plaza M, Batista ÂG, Cazarin CBB, Sandahl M, Turner C, Östman E, Júnior MRM (2016) Characterization of antioxidant polyphenols from Myrciaria jaboticaba peel and their effects on glucose metabolism and antioxidant status: a pilot clinical study. Food Chem 211:185–197. https://doi.org/10.1016/j.foodchem.2016.04.142. (PMID: 10.1016/j.foodchem.2016.04.14227283622)
Alam MN, Almoyad M, Huq F (2018) Polyphenols in colorectal cancer: current state of knowledge including clinical trials and molecular mechanism of action. Biomed Res Int 2018. https://doi.org/10.1155/2018/4154185.
do Carmo MAV, Fidelis M, de Oliveira PF, Feitoza LQ, Marques MJ, Ferreira EB, Oh WY, Shahidi F, Hellström J, Almeida LA (2021) Ellagitannins from jabuticaba (Myrciaria jaboticaba) seeds attenuated inflammation, oxidative stress, aberrant crypt foci, and modulated gut microbiota in rats with 1,2-dimethyl hydrazine-induced colon carcinogenesis. Food Chem Toxicol 154:112287. https://doi.org/10.1016/j.fct.2021.112287. (PMID: 10.1016/j.fct.2021.11228734058233)
Kasprzak-Drozd K, Oniszczuk T, Stasiak M, Oniszczuk A (2021) Beneficial effects of phenolic compounds on gut microbiota and metabolic syndrome. Int J Mol Sci 22(7):3715. https://doi.org/10.3390/ijms22073715. (PMID: 10.3390/ijms22073715339182848038165)
De Santis S, Liso M, Vacca M, Verna G, Cavalcanti E, Coletta S, Calabrese FM, Eri R, Lippolis A, Armentano R (2021) Dysbiosis triggers ACF development in genetically predisposed subjects. Cancers 13(2):283. https://doi.org/10.3390/cancers13020283. (PMID: 10.3390/cancers13020283334666657828790)
Selma MV, Espin JC, Tomas-Barberan FA (2009) Interaction between phenolics and gut microbiota: role in human health. J Agric Food Chem 57(15):6485–6501. https://doi.org/10.1021/jf902107d. (PMID: 10.1021/jf902107d19580283)
Anderson JC, Swede H, Rustagi T, Protiva P, Pleau D, Brenner BM, Rajan TV, Heinen CD, Levine JB, Rosenberg DW (2012) Aberrant crypt foci as predictors of colorectal neoplasia on repeat colonoscopy. Cancer Causes Control 23(2):355–361. https://doi.org/10.1007/s10552-011-9884-7. (PMID: 10.1007/s10552-011-9884-722187142)
Thomas F, Hehemann J-H, Rebuffet E, Czjzek M, Michel G (2011) Environmental and gut Bacteroidetes: the food connection. Front Microbiol 2:93. https://doi.org/10.3389/fmicb.2011.00093. (PMID: 10.3389/fmicb.2011.00093217478013129010)
Liang JQ, Li T, Nakatsu G, Chen YX, Yau TO, Chu E, Wong S, Szeto CH, Ng SC, Chan FK (2020) A novel faecal Lachnoclostridium marker for the non-invasive diagnosis of colorectal adenoma and cancer. Gut 69(7):1248–1257. https://doi.org/10.1136/gutjnl-2019-318532. (PMID: 10.1136/gutjnl-2019-31853231776231)
Goncalves P, Martel F (2016) Regulation of colonic epithelial butyrate transport: focus on colorectal cancer. Porto Biomed J 1(3):83–91. https://doi.org/10.1016/j.pbj.2016.04.004. (PMID: 10.1016/j.pbj.2016.04.004322585566806744)
Mirzaei R, Afaghi A, Babakhani S, Sohrabi MR, Hosseini-Fard SR, Babolhavaeji K, Akbari SKA, Yousefimashouf R, Karampoor S (2021) Role of microbiota-derived short-chain fatty acids in cancer development and prevention. Biomed Pharmacother 139:111619. https://doi.org/10.1016/j.biopha.2021.111619. (PMID: 10.1016/j.biopha.2021.11161933906079)
Perrin P, Pierre F, Patry Y, Champ M, Berreur M, Pradal G, Bornet F, Meflah K, Menanteau J (2001) Only fibres promoting a stable butyrate producing colonic ecosystem decrease the rate of aberrant crypt foci in rats. Gut 48(1):53–61. https://doi.org/10.1136/gut.48.1.53. (PMID: 10.1136/gut.48.1.53111158231728184)
Nogal A, Louca P, Zhang X, Wells PM, Steves CJ, Spector TD, Falchi M, Valdes AM, Menni C (2021) Circulating levels of the short-chain fatty acid acetate mediate the effect of the gut microbiome on visceral fat. Front Microbiol:1943. https://doi.org/10.3389/fmicb.2021.711359. (PMID: 10.3389/fmicb.2021.711359)
Daniel EM, Krupnick AS, Heur Y-H, Blinzler JA, Nims RW, Stoner GD (1989) Extraction, stability, and quantitation of ellagic acid in various fruits and nuts. J Food Compos Anal 2(4):338–349. https://doi.org/10.1016/0889-1575(89)90005-7. (PMID: 10.1016/0889-1575(89)90005-7)
Kumar KN, Raja SB, Vidhya N, Devaraj SN (2012) Ellagic acid modulates antioxidant status, ornithine decarboxylase expression, and aberrant crypt foci progression in 1,2-dimethylhydrazine-instigated colon preneoplastic lesions in rats. J Agric Food Chem 60(14):3665–3672. https://doi.org/10.1021/jf204128z. (PMID: 10.1021/jf204128z22439659)
Giftson JS, Jayanthi S, Nalini N (2010) Chemopreventive efficacy of gallic acid, an antioxidant and anticarcinogenic polyphenol, against 1,2-dimethylhydrazine induced rat colon carcinogenesis. Investig New Drugs 28(3):251–259. https://doi.org/10.1007/s10637-009-9241-9. (PMID: 10.1007/s10637-009-9241-9)
Núñez-Gómez V, Periago MJ, Navarro-González I, Campos-Cava MP, Baenas N, González-Barrio R (2021) Influence of raspberry and its dietary fractions on the in vitro activity of the Colonic Microbiota from normal and overweight subjects. Plant Foods Hum Nutr 76(4):494–500. https://doi.org/10.1007/s11130-021-00923-6. (PMID: 10.1007/s11130-021-00923-6346976728629792)
Rodríguez-Daza MC, Pulido-Mateos EC, Lupien-Meilleur J, Guyonnet D, Desjardins Y, Roy D (2021) Polyphenol-mediated gut microbiota modulation: toward prebiotics and further. Front Nutr 8:689456. https://doi.org/10.3389/fnut.2021.689456. (PMID: 10.3389/fnut.2021.689456342683288276758)
Kim YS, Milner JA (2007) Dietary modulation of colon cancer risk. J Nutr 137(11):2576S–2579. https://doi.org/10.1093/jn/137.11.2576S . S. (PMID: 10.1093/jn/137.11.2576S17951506)
Fidelis M, Santos JS, Escher GB, Rocha RS, Cruz AG, Cruz TM, Marques MB, Nunes JB, do, Carmo MAV, de Almeida LA (2021) Polyphenols of jabuticaba [Myrciaria jaboticaba (Vell.) O. Berg] seeds incorporated in a yogurt model exert antioxidant activity and modulate gut microbiota of 1,2-dimethylhydrazine-induced colon cancer in rats. Food Chem 334:127565. https://doi.org/10.1016/j.foodchem.2020.127565.
معلومات مُعتمدة: MOST 110-2320-B-126-003-MY3 Ministry of Science and Technology, R.O.C. Taiwan
فهرسة مساهمة: Keywords: 16s rDNA; Colorectal cancer; Gut microbiota; SCFA; Sprague-Dawley rats; Whole fruit
المشرفين على المادة: 632XD903SP (Gallic Acid)
0 (Butyrates)
IX068S9745 (1,2-Dimethylhydrazine)
تواريخ الأحداث: Date Created: 20230223 Date Completed: 20230724 Latest Revision: 20230724
رمز التحديث: 20240628
DOI: 10.1007/s11130-023-01051-z
PMID: 36820999
قاعدة البيانات: MEDLINE
الوصف
تدمد:1573-9104
DOI:10.1007/s11130-023-01051-z