دورية أكاديمية
أعرض في EDS

The Environmental Conditions, Treatments, and Exposures Ontology (ECTO): connecting toxicology and exposure to human health and beyond.

التفاصيل البيبلوغرافية
العنوان: The Environmental Conditions, Treatments, and Exposures Ontology (ECTO): connecting toxicology and exposure to human health and beyond.
المؤلفون: Chan LE; Oregon State University, Corvallis, OR, 97331, USA. chanl@oregonstate.edu., Thessen AE; Oregon State University, Corvallis, OR, 97331, USA.; University of Colorado Anschutz Medical Campus, Aurora, CO, 80054, USA., Duncan WD; University of Florida, Gainesville, FL, 32610, USA., Matentzoglu N; Semanticly, Athens, Greece., Schmitt C; National Institute of Environmental Health Sciences, Durham, NC, 27709, USA., Grondin CJ; North Carolina State University, Raleigh, NC, 27965, USA., Vasilevsky N; University of Colorado Anschutz Medical Campus, Aurora, CO, 80054, USA., McMurry JA; University of Colorado Anschutz Medical Campus, Aurora, CO, 80054, USA., Robinson PN; The Jackson Laboratory for Genomic Medicine, Farmington, CT, 06032, USA., Mungall CJ; Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA., Haendel MA; Oregon State University, Corvallis, OR, 97331, USA.; University of Colorado Anschutz Medical Campus, Aurora, CO, 80054, USA.
المصدر: Journal of biomedical semantics [J Biomed Semantics] 2023 Feb 24; Vol. 14 (1), pp. 3. Date of Electronic Publication: 2023 Feb 24.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Biomed Central Country of Publication: England NLM ID: 101531992 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1480 (Electronic) NLM ISO Abbreviation: J Biomed Semantics Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : Biomed Central
مواضيع طبية MeSH: Biological Ontologies*, Humans ; Databases, Factual
مستخلص: Background: Evaluating the impact of environmental exposures on organism health is a key goal of modern biomedicine and is critically important in an age of greater pollution and chemicals in our environment. Environmental health utilizes many different research methods and generates a variety of data types. However, to date, no comprehensive database represents the full spectrum of environmental health data. Due to a lack of interoperability between databases, tools for integrating these resources are needed. In this manuscript we present the Environmental Conditions, Treatments, and Exposures Ontology (ECTO), a species-agnostic ontology focused on exposure events that occur as a result of natural and experimental processes, such as diet, work, or research activities. ECTO is intended for use in harmonizing environmental health data resources to support cross-study integration and inference for mechanism discovery.
Methods and Findings: ECTO is an ontology designed for describing organismal exposures such as toxicological research, environmental variables, dietary features, and patient-reported data from surveys. ECTO utilizes the base model established within the Exposure Ontology (ExO). ECTO is developed using a combination of manual curation and Dead Simple OWL Design Patterns (DOSDP), and contains over 2700 environmental exposure terms, and incorporates chemical and environmental ontologies. ECTO is an Open Biological and Biomedical Ontology (OBO) Foundry ontology that is designed for interoperability, reuse, and axiomatization with other ontologies. ECTO terms have been utilized in axioms within the Mondo Disease Ontology to represent diseases caused or influenced by environmental factors, as well as for survey encoding for the Personalized Environment and Genes Study (PEGS).
Conclusions: We constructed ECTO to meet Open Biological and Biomedical Ontology (OBO) Foundry principles to increase translation opportunities between environmental health and other areas of biology. ECTO has a growing community of contributors consisting of toxicologists, public health epidemiologists, and health care providers to provide the necessary expertise for areas that have been identified previously as gaps.
(© 2023. The Author(s).)
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معلومات مُعتمدة: R24 OD011883 United States OD NIH HHS; RM1 HG010860 United States HG NHGRI NIH HHS; 5 R24 OD011883 United States NH NIH HHS
فهرسة مساهمة: Keywords: Biomedical ontology; Environmental exposures; Environmental health
تواريخ الأحداث: Date Created: 20230224 Date Completed: 20230227 Latest Revision: 20230406
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9951428
DOI: 10.1186/s13326-023-00283-x
PMID: 36823605
قاعدة البيانات: MEDLINE
الوصف
تدمد:2041-1480
DOI:10.1186/s13326-023-00283-x