دورية أكاديمية
Gender difference in the association between gout at diagnosis and metabolic syndrome in African population: a retrospective cohort study.
| العنوان: | Gender difference in the association between gout at diagnosis and metabolic syndrome in African population: a retrospective cohort study. |
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| المؤلفون: | Lekpa FK; Rheumatology Unit, Department of Internal Medicine, Douala General Hospital, Douala, Cameroon.; Department of Internal Medicine and Specialties, Faculty of Medicine and Pharmaceutical Sciences, University of Dschang, Dschang, Cameroon.; Health and Human Development Research Group, Douala, Cameroon., Bebey FS; Department of Clinical Sciences, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon., Bouallo I; Rheumatology Unit, Department of Internal Medicine, Douala General Hospital, Douala, Cameroon., Njonnou SRS; Department of Internal Medicine and Specialties, Faculty of Medicine and Pharmaceutical Sciences, University of Dschang, Dschang, Cameroon.; Health and Human Development Research Group, Douala, Cameroon., Luma HN; Rheumatology Unit, Department of Internal Medicine, Douala General Hospital, Douala, Cameroon.; Department of Internal medicine and subspecialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon., Singwe-Ngandeu M; Department of Internal medicine and subspecialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon.; Department of Rheumatology, Yaoundé Central Hospital, Yaoundé, Cameroon., Choukem SP; Rheumatology Unit, Department of Internal Medicine, Douala General Hospital, Douala, Cameroon.; Department of Internal Medicine and Specialties, Faculty of Medicine and Pharmaceutical Sciences, University of Dschang, Dschang, Cameroon.; Health and Human Development Research Group, Douala, Cameroon. |
| المصدر: | The Pan African medical journal [Pan Afr Med J] 2022 Dec 01; Vol. 43, pp. 164. Date of Electronic Publication: 2022 Dec 01 (Print Publication: 2022). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: African Field Epidemiology Network Country of Publication: Uganda NLM ID: 101517926 Publication Model: eCollection Cited Medium: Internet ISSN: 1937-8688 (Electronic) NLM ISO Abbreviation: Pan Afr Med J Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Kampala, Uganda : African Field Epidemiology Network |
| مواضيع طبية MeSH: | Metabolic Syndrome*/diagnosis , Metabolic Syndrome*/epidemiology , Gout*/diagnosis , Gout*/epidemiology , Hypertension*/epidemiology , Hypertension*/complications, Male ; Humans ; Female ; Middle Aged ; Aged ; Uric Acid ; Retrospective Studies ; Sex Factors ; Cameroon/epidemiology ; Obesity/epidemiology ; Obesity/complications ; Waist Circumference ; Risk Factors |
| مستخلص: | Introduction: few studies have specifically investigated the link between metabolic syndrome (MetS) and gout in sub-Saharan Africa. This report aimed to evaluate in patients with gout the association between gout at diagnosis and MetS and to assess the gender difference. Methods: we performed a single-centre retrospective cohort study on all outpatients seen in the Rheumatology Unit of the General Hospital, Douala, Cameroon. We included records of patients with a recent diagnosis of gout according to the American College of Radiology (ACR) criteria. MetS was defined according to the harmonized criteria. Results: we included 511 patients (415 men), with a mean age at diagnosis of 55.9 ±10.8 years. Women were older than men. The mean serum uric acid was 8.24±2.23 mg/L, with hyperuricemia found in 394 patients (77.1%). MetS was present in 101 patients (19.7% [95% CI: 16.8%-22.1%]), significantly more common in men compared to women (23.6% vs. 10.8%; p<0.001). The main components of the MetS were: increased waist circumference (217 patients, 61.3%), obesity (256 patients, 52.2%), hypertension (208 patients, 40.7%), and diabetes mellitus (52 patients, 10.2%). Furthermore, hypertension, diabetes mellitus, obesity, and increased waist circumference were more frequent in women (p<0.001). There was no difference in dyslipidemia according to gender. The combination of components of the MetS was more frequent in men than women (p<0.001). Conclusion: MetS are common in newly diagnosed Cameroonian patients with gout, with increased waist circumference, obesity, hypertension and diabetes mellitus being the main components. These components are more common in women, but their combination was more frequent in men. Competing Interests: The authors declare no competing interests. (Copyright: Fernando Kemta Lekpa et al.) |
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| فهرسة مساهمة: | Keywords: Gout; female; hyperuricemia; metabolic syndrome |
| المشرفين على المادة: | 268B43MJ25 (Uric Acid) |
| تواريخ الأحداث: | Date Created: 20230224 Date Completed: 20230227 Latest Revision: 20230227 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC9941612 |
| DOI: | 10.11604/pamj.2022.43.164.37197 |
| PMID: | 36825121 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1937-8688 |
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| DOI: | 10.11604/pamj.2022.43.164.37197 |