دورية أكاديمية
Insight into Oncogenic Viral Pathways as Drivers of Viral Cancers: Implication for Effective Therapy.
| العنوان: | Insight into Oncogenic Viral Pathways as Drivers of Viral Cancers: Implication for Effective Therapy. |
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| المؤلفون: | Elkhalifa AME; Department of Public Health, College of Health Sciences, Saudi Electronic University, Riyadh 11673, Saudi Arabia.; Department of Haematology, Faculty of Medical Laboratory Sciences, University of El Imam El Mahdi, Kosti 1158, Sudan., Nabi SU; Large Animal Diagnostic Laboratory, Department of Clinical Veterinary Medicine, Ethics & Jurisprudence, Faculty of Veterinary Sciences and Animal Husbandry, Sher-e-Kashmir University of Agricultural Sciences and Technology, Srinagar 190006, Jammu and Kashmir, India., Shah OS; Department of Sheep Husbandry Kashmir, Government of Jammu and Kashmir, Srinagar 182301, Jammu and Kashmir, India., Bashir SM; Biochemistry & Molecular Biology Lab, Division of Veterinary Biochemistry, Faculty of Veterinary Sciences and Animal Husbandry, Sher-e-Kashmir University of Agricultural Sciences and Technology, Srinagar 190006, Jammu and Kashmir, India., Muzaffer U; Department of Medicine, Government Medical College and Associated Hospital, Srinagar 190010, Jammu and Kashmir, India., Ali SI; Biochemistry & Molecular Biology Lab, Division of Veterinary Biochemistry, Faculty of Veterinary Sciences and Animal Husbandry, Sher-e-Kashmir University of Agricultural Sciences and Technology, Srinagar 190006, Jammu and Kashmir, India., Wani IA; Clinical Research Laboratory, SKIMS, Srinagar 190011, Jammu and Kashmir, India., Alzerwi NAN; Department of Surgery, College of Medicine, Majmaah University, Ministry of Education, Al Majmaah 11952, Saudi Arabia., Elderdery AY; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka 72388, Saudi Arabia., Alanazi A; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka 72388, Saudi Arabia., Alenazy FO; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka 72388, Saudi Arabia., Alharbi AHA; Hail Regional Laboratory, Hail 55471, Saudi Arabia. |
| المصدر: | Current oncology (Toronto, Ont.) [Curr Oncol] 2023 Feb 05; Vol. 30 (2), pp. 1924-1944. Date of Electronic Publication: 2023 Feb 05. |
| نوع المنشور: | Journal Article; Review; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 9502503 Publication Model: Electronic Cited Medium: Internet ISSN: 1718-7729 (Electronic) Linking ISSN: 11980052 NLM ISO Abbreviation: Curr Oncol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2021- : Basel, Switzerland : MDPI Original Publication: Toronto : Multimed, c1994- |
| مواضيع طبية MeSH: | COVID-19* , Neoplasms*/genetics, Humans ; SARS-CoV-2 ; Oncogenic Viruses ; Carcinogenesis ; Genomics ; Tumor Microenvironment |
| مستخلص: | As per a recent study conducted by the WHO, 15.4% of all cancers are caused by infectious agents of various categories, and more than 10% of them are attributed to viruses. The emergence of COVID-19 has once again diverted the scientific community's attention toward viral diseases. Some researchers have postulated that SARS-CoV-2 will add its name to the growing list of oncogenic viruses in the long run. However, owing to the complexities in carcinogenesis of viral origin, researchers across the world are struggling to identify the common thread that runs across different oncogenic viruses. Classical pathways of viral oncogenesis have identified oncogenic mediators in oncogenic viruses, but these mediators have been reported to act on diverse cellular and multiple omics pathways. In addition to viral mediators of carcinogenesis, researchers have identified various host factors responsible for viral carcinogenesis. Henceforth owing to viral and host complexities in viral carcinogenesis, a singular mechanistic pathway remains yet to be established; hence there is an urgent need to integrate concepts from system biology, cancer microenvironment, evolutionary perspective, and thermodynamics to understand the role of viruses as drivers of cancer. In the present manuscript, we provide a holistic view of the pathogenic pathways involved in viral oncogenesis with special emphasis on alteration in the tumor microenvironment, genomic alteration, biological entropy, evolutionary selection, and host determinants involved in the pathogenesis of viral tumor genesis. These concepts can provide important insight into viral cancers, which can have an important implication for developing novel, effective, and personalized therapeutic options for treating viral cancers. |
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| فهرسة مساهمة: | Keywords: bio-thermodynamics; cancer; genome; metabolic; oncogenes; pathogenesis; transition; virus |
| تواريخ الأحداث: | Date Created: 20230224 Date Completed: 20230228 Latest Revision: 20230321 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC9955780 |
| DOI: | 10.3390/curroncol30020150 |
| PMID: | 36826111 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1718-7729 |
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| DOI: | 10.3390/curroncol30020150 |