دورية أكاديمية
أعرض في EDS

Sarcopenia of kidney transplant recipients as a predictive marker for reduced graft function and graft survival after kidney transplantation.

التفاصيل البيبلوغرافية
العنوان: Sarcopenia of kidney transplant recipients as a predictive marker for reduced graft function and graft survival after kidney transplantation.
المؤلفون: Karakizlis H; Department of Internal Medicine II, Division of Nephrology and Renal Transplantation, Justus-Liebig-University of Giessen, Giessen, Germany., Trudel N; Department of General, Visceral and Thoracic Surgery, Justus-Liebig-University of Giessen, Rudolf-Buchheim-Str. 7, Giessen, Germany.; Department of Diagnostic and Interventional Radiology, Marienhospital Stuttgart, Stuttgart, Germany., Brose A; Department of Radiology, Justus-Liebig-University of Giessen, Giessen, Germany., Reinisch A; Department of General, Visceral and Oncologic Surgery, Hospital and Clinics Wetzlar, Teaching Hospital of the Justus-Liebig-University Giessen, Wetzlar, Germany., Reichert M; Department of General, Visceral and Thoracic Surgery, Justus-Liebig-University of Giessen, Rudolf-Buchheim-Str. 7, Giessen, Germany., Hecker A; Department of General, Visceral and Thoracic Surgery, Justus-Liebig-University of Giessen, Rudolf-Buchheim-Str. 7, Giessen, Germany., Bender F; Department of General, Visceral and Thoracic Surgery, Justus-Liebig-University of Giessen, Rudolf-Buchheim-Str. 7, Giessen, Germany., Askevold I; Department of General, Visceral and Thoracic Surgery, Justus-Liebig-University of Giessen, Rudolf-Buchheim-Str. 7, Giessen, Germany., Rainer L; Department of Internal Medicine II, Division of Nephrology and Renal Transplantation, Justus-Liebig-University of Giessen, Giessen, Germany., Weimer R; Department of Internal Medicine II, Division of Nephrology and Renal Transplantation, Justus-Liebig-University of Giessen, Giessen, Germany., Krombach GA; Department of Radiology, Justus-Liebig-University of Giessen, Giessen, Germany., Padberg W; Department of General, Visceral and Thoracic Surgery, Justus-Liebig-University of Giessen, Rudolf-Buchheim-Str. 7, Giessen, Germany., Liese J; Department of General, Visceral and Thoracic Surgery, Justus-Liebig-University of Giessen, Rudolf-Buchheim-Str. 7, Giessen, Germany. Juliane.liese@chiru.med.uni-giessen.de.
المصدر: Langenbeck's archives of surgery [Langenbecks Arch Surg] 2023 Feb 24; Vol. 408 (1), pp. 103. Date of Electronic Publication: 2023 Feb 24.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 9808285 Publication Model: Electronic Cited Medium: Internet ISSN: 1435-2451 (Electronic) Linking ISSN: 14352443 NLM ISO Abbreviation: Langenbecks Arch Surg Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Berlin : Springer-Verlag, c1998-
مواضيع طبية MeSH: Kidney Transplantation*/adverse effects , Sarcopenia*, Male ; Humans ; Female ; Graft Survival ; Retrospective Studies ; Transplant Recipients ; Tissue Donors ; Graft Rejection
مستخلص: Purpose: The association between sarcopenia of kidney transplant recipients and outcome after kidney transplantation (KT) has not yet been fully understood and is still considered controversial. The aim of our study was to analyze the impact of pre-transplant sarcopenia on graft function, postoperative complication rates, and survival of the patients after renal transplantation.
Methods: In this retrospective single-center study, all patients who underwent KT (01/2013-12/2017) were included. Demographic data, rejection rates, delayed graft function, and graft and patient survival rates were analyzed. Sarcopenia was measured in computed tomography images by the sex-adjusted Hounsfield unit average calculation (HUAC).
Results: During the study period, 111 single KTs (38 women and 73 men) were performed. Living donor kidney transplants were performed in 48.6%. In total, 32.4% patients had sarcopenia. Sarcopenic patients were significantly older (59.6 years vs. 49.8 years; p < 0.001), had a higher body mass index (BMI = 27.6 kg/m 2 vs. 25.0 kg/m 2 ; p = 0.002), and were more likely to receive deceased donor kidneys (72.2% vs. 41.3%; p = 0.002). Interestingly, 3 years after KT, the creatinine serum levels were significantly higher (2.0 mg/dl vs. 1.5 mg/dl; p = 0.001), whereas eGFR (39.9 ml/min vs. 53.4 ml/min; p = 0.001) and graft survival were significantly lower (p = 0.004) in sarcopenic transplant recipients. Sarcopenic patients stayed in hospital significantly longer postoperatively than those who were non-sarcopenic.
Conclusions: At the time of kidney transplantation, sarcopenia was found to predict reduced long-term graft function and diminished graft survival after KT. The early identification of sarcopenic patients can not only enable an optimized selection of recipients, but also the initiation of pre-habilitation programs during the waiting period.
(© 2023. The Author(s).)
References: Health Qual Life Outcomes. 2013 May 30;11:88. (PMID: 23721430)
Ann Surg Oncol. 2021 Nov;28(12):7185-7195. (PMID: 33876359)
Front Nutr. 2019 Nov 12;6:169. (PMID: 31781571)
Am J Transplant. 2013 Jun;13(6):1549-56. (PMID: 23601159)
Clin Transplant. 2017 Mar;31(3):. (PMID: 28075034)
Clin Exp Nephrol. 2020 Apr;24(4):379-383. (PMID: 31875933)
J Chronic Dis. 1987;40(5):373-83. (PMID: 3558716)
Clin Transplant. 2015 Feb;29(2):167-75. (PMID: 25377026)
BMC Geriatr. 2021 Dec 23;21(1):730. (PMID: 34949161)
Nephrol Dial Transplant. 2008 Sep;23(9):2995-3003. (PMID: 18408075)
Eur Radiol. 2014 May;24(5):998-1005. (PMID: 24535076)
J Cachexia Sarcopenia Muscle. 2022 Feb;13(1):86-99. (PMID: 34816624)
Clin Nutr. 2021 May;40(5):2809-2816. (PMID: 33933747)
Ann Surg Oncol. 2018 May;25(5):1160-1166. (PMID: 29404820)
Am J Transplant. 2011 Oct;11(10):2093-109. (PMID: 21883901)
J Nutr Health Aging. 2009 Oct;13(8):724-8. (PMID: 19657557)
Ann Surg Oncol. 2022 Mar;29(3):1553-1563. (PMID: 34716836)
World J Surg. 2018 Oct;42(10):3364-3371. (PMID: 29691621)
Clin J Am Soc Nephrol. 2011 Jun;6(6):1463-73. (PMID: 21415312)
J Gastrointest Surg. 2015 Sep;19(9):1593-602. (PMID: 25925237)
Liver Transpl. 2013 Nov;19(11):1172-80. (PMID: 23960026)
Transplant Proc. 2022 Sep;54(7):1816-1821. (PMID: 35933230)
Transplantation. 2008 Aug 15;86(3):391-8. (PMID: 18698241)
Transplant Direct. 2020 Sep 25;6(10):e610. (PMID: 33062843)
N Engl J Med. 1999 Dec 2;341(23):1725-30. (PMID: 10580071)
JAMA Netw Open. 2021 Aug 2;4(8):e2115274. (PMID: 34459908)
World J Surg. 2021 Jul;45(7):2218-2226. (PMID: 33842995)
Cancers (Basel). 2022 Jan 05;14(1):. (PMID: 35008425)
Ann Surg. 2004 Aug;240(2):205-13. (PMID: 15273542)
Curr Opin Nephrol Hypertens. 2022 Nov 1;31(6):560-565. (PMID: 36172855)
JAMA. 1993 Sep 15;270(11):1339-43. (PMID: 8360969)
Clin Nutr. 2017 Jun;36(3):663-671. (PMID: 27371993)
Eur J Surg Oncol. 2018 May;44(5):658-663. (PMID: 29428474)
J Thorac Dis. 2021 Mar;13(3):1358-1369. (PMID: 33841929)
Nephrourol Mon. 2014 Jul 05;6(4):e20055. (PMID: 25695027)
Am J Nephrol. 2022;53(6):427-434. (PMID: 35584614)
Am J Kidney Dis. 2019 Mar;73(3 Suppl 1):A7-A8. (PMID: 30798791)
Front Nutr. 2022 May 13;9:896427. (PMID: 35634393)
Nutrients. 2022 Jun 05;14(11):. (PMID: 35684154)
World J Urol. 2021 Jun;39(6):2223-2230. (PMID: 32785765)
Clin Res Hepatol Gastroenterol. 2021 Jul;45(4):101692. (PMID: 33848672)
Int Urol Nephrol. 2022 Aug;54(8):1977-1986. (PMID: 35028810)
World J Gastrointest Surg. 2016 Jan 27;8(1):27-40. (PMID: 26843911)
Am J Transplant. 2013 Aug;13(8):2091-5. (PMID: 23731461)
Tech Coloproctol. 2019 Sep;23(9):877-885. (PMID: 31486988)
Transplant Rev (Orlando). 2014 Oct;28(4):188-92. (PMID: 25154797)
Clin Nutr ESPEN. 2017 Dec;22:76-80. (PMID: 29415839)
Colorectal Dis. 2015 Nov;17(11):O256-64. (PMID: 26194849)
J Korean Med Sci. 2022 May 09;37(18):e146. (PMID: 35535373)
فهرسة مساهمة: Keywords: Graft survival; HUAC; Kidney function; Kidney transplantation; Sarcopenia
تواريخ الأحداث: Date Created: 20230224 Date Completed: 20230228 Latest Revision: 20240121
رمز التحديث: 20240121
مُعرف محوري في PubMed: PMC9958183
DOI: 10.1007/s00423-023-02836-1
PMID: 36826595
قاعدة البيانات: MEDLINE
الوصف
تدمد:1435-2451
DOI:10.1007/s00423-023-02836-1