دورية أكاديمية

The Burden of Pneumocystis Pneumonia Infection among HIV Patients in Ethiopia: A Systematic Review.

التفاصيل البيبلوغرافية
العنوان: The Burden of Pneumocystis Pneumonia Infection among HIV Patients in Ethiopia: A Systematic Review.
المؤلفون: Gelaw YM; Department of Health Service and Economics, School of Public Health, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar H9FX+Q62, Ethiopia.; Irset (Institut de Recherche en Santé, Environnement et Travail), UMR_S 1085, Univ Rennes, CHU Rennes, Inserm, EHESP, F-35000 Rennes, France., Guracho YD; Department of Health Service and Economics, School of Public Health, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar H9FX+Q62, Ethiopia.; Faculty of Engineering and Information Sciences, University of Wollongong, Wollongong 2500, Australia., Robert-Gangneux F; Irset (Institut de Recherche en Santé, Environnement et Travail), UMR_S 1085, Univ Rennes, CHU Rennes, Inserm, EHESP, F-35000 Rennes, France., Alene GD; Department of Health Service and Economics, School of Public Health, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar H9FX+Q62, Ethiopia., Gangneux JP; Irset (Institut de Recherche en Santé, Environnement et Travail), UMR_S 1085, Univ Rennes, CHU Rennes, Inserm, EHESP, F-35000 Rennes, France.
المصدر: Tropical medicine and infectious disease [Trop Med Infect Dis] 2023 Feb 13; Vol. 8 (2). Date of Electronic Publication: 2023 Feb 13.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101709042 Publication Model: Electronic Cited Medium: Internet ISSN: 2414-6366 (Electronic) Linking ISSN: 24146366 NLM ISO Abbreviation: Trop Med Infect Dis Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2016]-
مستخلص: Pneumocystis pneumonia (PCP) is a leading cause of death among patients with AIDS worldwide, but its burden is difficult to estimate in low- and middle-income countries, including Ethiopia. This systematic review aimed to estimate the pooled prevalence of PCP in Ethiopia, the second most densely populated African country. The Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines were used to review published and unpublished studies conducted in Ethiopia. Studies that reported on the prevalence of PCP among HIV-infected patients were searched systematically. Variations between the studies were assessed by using forest plot and I-squared heterogeneity tests. Subgroup and sensitivity analyses were carried out when I2 > 50. The pooled estimate prevalence with 95% CI was computed using a random-effects model of analysis. Thirteen articles, comprising studies of 4847 individuals living with HIV, were included for analysis. The pooled prevalence of PCP was 5.65% (95% CI [3.74-7.56]) with high heterogeneity (I2 = 93.6%, p < 0.01). To identify the source of heterogeneity, subgroup analyses were conducted by study design, geographical region, diagnosis methods, and year of publication. PCP prevalence differed significantly when biological diagnostic methods were used (32.25%), in studies published before 2010 (32.51%), in cross-sectional studies (8.08%), and in Addis Ababa (14.05%). PCP prevalence differences of 3.25%, 3.07%, 3.23%, and 2.29% were recorded in studies based on clinical records, published since 2017, follow-up studies, and north-west Ethiopian studies, respectively. The prevalence of PCP is probably underestimated, as the reports were mainly based on clinical records. An expansion of biological diagnostic methods could make it possible to estimate the exact burden of PCP in Ethiopia.
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معلومات مُعتمدة: 971899L Campus France
فهرسة مساهمة: Keywords: Africa; Ethiopia; HIV; Pneumocystis jirovecii; Pneumocystis pneumonia; burden; fungal diseases; systematic review
تواريخ الأحداث: Date Created: 20230224 Latest Revision: 20230301
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9965859
DOI: 10.3390/tropicalmed8020114
PMID: 36828530
قاعدة البيانات: MEDLINE
الوصف
تدمد:2414-6366
DOI:10.3390/tropicalmed8020114