دورية أكاديمية
أعرض في EDS

Impact of Prenatal Alcohol Exposure on the Development and Myocardium of Adult Mice: Morphometric Changes, Transcriptional Modulation of Genes Related to Cardiac Dysfunction, and Antioxidant Cardioprotection.

التفاصيل البيبلوغرافية
العنوان: Impact of Prenatal Alcohol Exposure on the Development and Myocardium of Adult Mice: Morphometric Changes, Transcriptional Modulation of Genes Related to Cardiac Dysfunction, and Antioxidant Cardioprotection.
المؤلفون: Atum ALB; Medicine Department, Universidade Nove de Julho-UNINOVE, Rua Vergueiro 249, São Paulo 01504-001, SP, Brazil., de Matos LP; Medicine Department, Universidade Nove de Julho-UNINOVE, Rua Vergueiro 249, São Paulo 01504-001, SP, Brazil., de Jesus BC; Medicine Department, Universidade Nove de Julho-UNINOVE, Rua Vergueiro 249, São Paulo 01504-001, SP, Brazil., Nasuk GR; Medicine Department, Universidade Nove de Julho-UNINOVE, Rua Vergueiro 249, São Paulo 01504-001, SP, Brazil., da Silva GA; Medicine Department, Universidade Nove de Julho-UNINOVE, Rua Vergueiro 249, São Paulo 01504-001, SP, Brazil., Gomes CP; Biophysics Department, Universidade Federal de São Paulo, Rua Pedro de Toledo 669, São Paulo 04039-032, SP, Brazil., Pesquero JB; Biophysics Department, Universidade Federal de São Paulo, Rua Pedro de Toledo 669, São Paulo 04039-032, SP, Brazil., Zamuner SR; Medicine Department, Universidade Nove de Julho-UNINOVE, Rua Vergueiro 249, São Paulo 01504-001, SP, Brazil., Silva Júnior JA; Medicine Department, Universidade Nove de Julho-UNINOVE, Rua Vergueiro 249, São Paulo 01504-001, SP, Brazil.
المصدر: Antioxidants (Basel, Switzerland) [Antioxidants (Basel)] 2023 Jan 23; Vol. 12 (2). Date of Electronic Publication: 2023 Jan 23.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101668981 Publication Model: Electronic Cited Medium: Print ISSN: 2076-3921 (Print) Linking ISSN: 20763921 NLM ISO Abbreviation: Antioxidants (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2012]-
مستخلص: The impact of prenatal alcohol exposure (PAE) varies considerably between individuals, leading to morphological and genetic changes. However, minor changes usually go undetected in PAE children. We investigated PAE's effects on gene transcription of genes related to cardiac dysfunction signaling in mouse myocardium and morphological changes. C57Bl/6 mice were subjected to a 10% PAE protocol. In postnatal days 2 and 60 (PN2 and PN60), morphometric measurements in the offspring were performed. Ventricular samples of the heart were collected in PN60 from male offspring for quantification of mRNA expression of 47 genes of nine myocardial signal transduction pathways related to cardiovascular dysfunction. Animals from the PAE group presented low birth weight than the Control group, but the differences were abolished in adult mice. In contrast, the mice's size was similar in PN2; however, PAE mice were oversized at PN60 compared with the Control group. Cardiac and ventricular indexes were increased in PAE mice. PAE modulated the mRNA expression of 43 genes, especially increasing the expressions of genes essential for maladaptive tissue remodeling. PAE animals presented increased antioxidant enzyme activities in the myocardium. In summary, PAE animals presented morphometric changes, transcription of cardiac dysfunction-related genes, and increased antioxidant protection in the myocardium.
References: J Cell Sci. 2005 Aug 15;118(Pt 16):3569-72. (PMID: 16105880)
Environ Res. 2019 Jun;173:528-538. (PMID: 30991176)
J Am Soc Nephrol. 2010 Nov;21(11):1891-902. (PMID: 20829403)
Am J Obstet Gynecol. 2012 Apr;206(4):358.e19-22. (PMID: 22365038)
Curr Med Chem Cardiovasc Hematol Agents. 2005 Apr;3(2):87-98. (PMID: 15853696)
Circulation. 2007 Sep 18;116(12):1413-23. (PMID: 17875982)
Brain Res Mol Brain Res. 1997 Oct 3;49(1-2):283-90. (PMID: 9387889)
Circulation. 2006 May 16;113(19):2335-62. (PMID: 16702488)
Circulation. 1993 May;87(5):1451-60. (PMID: 8490999)
Psychoneuroendocrinology. 2013 Oct;38(10):1953-66. (PMID: 23579081)
Healthcare (Basel). 2022 Jan 02;10(1):. (PMID: 35052248)
Circulation. 1996 Dec 15;94(12):3184-9. (PMID: 8989127)
J Am Acad Psychiatry Law. 2022 Dec;50(4):509-516. (PMID: 36535783)
J Dev Behav Pediatr. 2015 Apr;36(3):197-202. (PMID: 25767932)
Ann Clin Lab Sci. 2010 Spring;40(2):99-114. (PMID: 20421621)
J Epidemiol Community Health. 2014 Jun;68(6):542-9. (PMID: 24616351)
Biol Sex Differ. 2019 Apr 22;10(1):21. (PMID: 31010438)
Addiction. 2017 Jun;112(6):968-1001. (PMID: 28220587)
Birth Defects Res. 2021 Apr 15;113(7):521-534. (PMID: 32578335)
Alcohol. 2006 Jul;39(3):169-78. (PMID: 17127136)
BJOG. 2011 Nov;118(12):1411-21. (PMID: 21729235)
Biochem Cell Biol. 2018 Apr;96(2):131-147. (PMID: 29370535)
Circulation. 2005 May 17;111(19):2430-7. (PMID: 15867170)
Nephrol Dial Transplant. 2004 Jul;19(7):1829-34. (PMID: 15128888)
Am J Obstet Gynecol. 2010 Jul;203(1):75.e7-75.e15. (PMID: 20451895)
Clin Exp Pharmacol Physiol. 2010 Feb;37(2):e91-8. (PMID: 19930419)
Mol Brain. 2011 Jul 07;4:29. (PMID: 21736737)
Lancet Glob Health. 2017 Mar;5(3):e290-e299. (PMID: 28089487)
Physiology (Bethesda). 2013 Nov;28(6):391-403. (PMID: 24186934)
Alcohol Alcohol. 2002 Jan-Feb;37(1):30-7. (PMID: 11825854)
J Physiol. 2007 Mar 1;579(Pt 2):287-8. (PMID: 17234705)
Lasers Surg Med. 2021 Nov;53(9):1247-1257. (PMID: 33846991)
Neurotoxicol Teratol. 2003 Mar-Apr;25(2):131-282. (PMID: 12748001)
J Toxicol Sci. 2021;46(9):413-423. (PMID: 34470993)
Cell Stress Chaperones. 2019 Sep;24(5):917-926. (PMID: 31410726)
J Pharmacol Exp Ther. 2006 Aug;318(2):819-27. (PMID: 16651399)
Brain Res Rev. 2011 Jun 24;67(1-2):209-25. (PMID: 21315761)
J Mol Cell Cardiol. 2000 Dec;32(12):2131-9. (PMID: 11112989)
Cardiovasc Res. 2004 Aug 15;63(3):467-75. (PMID: 15276472)
Alcohol. 2002 Feb;26(2):75-81. (PMID: 12007582)
Am J Physiol. 1982 Dec;243(6):H941-7. (PMID: 6216817)
Alcohol Clin Exp Res. 2003 Dec;27(12):2009-16. (PMID: 14691390)
Prog Neurobiol. 2003 Aug;70(6):443-62. (PMID: 14568359)
Eur J Prev Cardiol. 2020 Mar;27(4):410-421. (PMID: 31578093)
Am J Physiol Heart Circ Physiol. 2011 Feb;300(2):H645-51. (PMID: 21076018)
FASEB J. 2000 Oct;14(13):1858-60. (PMID: 11023967)
Alcohol Clin Exp Res. 1999 Sep;23(9):1552-60. (PMID: 10512323)
Pharmacol Res. 2007 Jun;55(6):570-7. (PMID: 17566760)
Life Sci. 2000 Aug 25;67(14):1683-93. (PMID: 11021353)
J Am Coll Cardiol. 2012 Apr 17;59(16):1477-86. (PMID: 22497828)
J Physiol. 2019 Dec;597(23):5619-5637. (PMID: 31595508)
Cardiovasc Toxicol. 2019 Oct;19(5):389-400. (PMID: 30684169)
Circulation. 2011 Mar 29;123(12):1297-305. (PMID: 21403100)
Int J Environ Res Public Health. 2022 Nov 25;19(23):. (PMID: 36497738)
Alcohol Res Health. 2000;24(2):93-104. (PMID: 11199283)
Alcohol Clin Exp Res. 2010 Jun;34(6):976-87. (PMID: 20374217)
Life Sci Alliance. 2019 Mar 4;2(2):. (PMID: 30833415)
Toxicology. 2021 Jun 30;458:152848. (PMID: 34217791)
Exp Biol Med (Maywood). 2005 Jun;230(6):394-406. (PMID: 15956769)
Int J Environ Res Public Health. 2021 Jul 27;18(15):. (PMID: 34360212)
Cardiol Young. 2007 Apr;17(2):185-8. (PMID: 17244381)
Eur J Neurosci. 2008 Oct;28(8):1641-53. (PMID: 18979677)
J Cardiol. 2011 Mar;57(2):131-40. (PMID: 21296556)
Front Physiol. 2018 Jun 05;9:692. (PMID: 29922182)
J Clin Invest. 2001 Apr;107(8):975-84. (PMID: 11306601)
معلومات مُعتمدة: 312381/2021-2 National Council for Scientific and Technological Development
فهرسة مساهمة: Keywords: cardiac dysfunction; myocardium; oxidative stress; prenatal alcohol exposure; signal transduction
تواريخ الأحداث: Date Created: 20230225 Latest Revision: 20230228
رمز التحديث: 20230228
مُعرف محوري في PubMed: PMC9952294
DOI: 10.3390/antiox12020256
PMID: 36829814
قاعدة البيانات: MEDLINE
الوصف
تدمد:2076-3921
DOI:10.3390/antiox12020256