دورية أكاديمية
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Complementing Testicular Immune Regulation: The Relationship between Sertoli Cells, Complement, and the Immune Response.

التفاصيل البيبلوغرافية
العنوان: Complementing Testicular Immune Regulation: The Relationship between Sertoli Cells, Complement, and the Immune Response.
المؤلفون: Washburn RL; Immunology and Infectious Diseases, Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center, Lubbock, TX 79424, USA.; Department of Cell Biology and Biochemistry, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79424, USA., Dufour JM; Department of Cell Biology and Biochemistry, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79424, USA.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2023 Feb 08; Vol. 24 (4). Date of Electronic Publication: 2023 Feb 08.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Testis* , Sertoli Cells*/metabolism, Male ; Humans ; Spermatogenesis/physiology ; Autoimmunity ; Complement System Proteins/metabolism
مستخلص: Sertoli cells within the testis are instrumental in providing an environment for spermatogenesis and protecting the developing germ cells from detrimental immune responses which could affect fertility. Though these immune responses consist of many immune processes, this review focuses on the understudied complement system. Complement consists of 50+ proteins including regulatory proteins, immune receptors, and a cascade of proteolytic cleavages resulting in target cell destruction. In the testis, Sertoli cells protect the germ cells from autoimmune destruction by creating an immunoregulatory environment. Most studies on Sertoli cells and complement have been conducted in transplantation models, which are effective in studying immune regulation during robust rejection responses. In grafts, Sertoli cells survive activated complement, have decreased deposition of complement fragments, and express many complement inhibitors. Moreover, the grafts have delayed infiltration of immune cells and contain increased infiltration of immunosuppressive regulatory T cells as compared to rejecting grafts. Additionally, anti-sperm antibodies and lymphocyte infiltration have been detected in up to 50% and 30% of infertile testes, respectively. This review seeks to provide an updated overview of the complement system, describe its relationship with immune cells, and explain how Sertoli cells may regulate complement in immunoprotection. Identifying the mechanism Sertoli cells use to protect themselves and germ cells against complement and immune destruction is relevant for male reproduction, autoimmunity, and transplantation.
References: J Intern Med. 2017 Aug;282(2):116-128. (PMID: 28345259)
Am J Pathol. 2011 Aug;179(2):766-74. (PMID: 21704012)
J Pathol. 2008 Jun;215(2):108-17. (PMID: 18381617)
PLoS One. 2020 May 4;15(5):e0232432. (PMID: 32365067)
Am J Respir Cell Mol Biol. 2003 Oct;29(4):472-82. (PMID: 12714373)
J Leukoc Biol. 2007 Oct;82(4):956-67. (PMID: 17675563)
Immunol Lett. 2015 Apr;164(2):117-24. (PMID: 25742728)
J Exp Med. 2013 Feb 11;210(2):257-68. (PMID: 23382542)
Front Immunol. 2018 Nov 29;9:2808. (PMID: 30555480)
Behring Inst Mitt. 1989 Jul;(84):204-15. (PMID: 2679533)
Andrologia. 1980 Mar-Apr;12(2):122-9. (PMID: 6992650)
J Allergy Clin Immunol. 2022 Dec 29;:. (PMID: 36587848)
Microbiol Immunol. 2002;46(2):131-4. (PMID: 11939578)
J Immunol. 2006 Mar 15;176(6):3525-35. (PMID: 16517721)
Immunol Lett. 2017 Sep;189:64-72. (PMID: 28554712)
Endocrinology. 2004 Mar;145(3):1481-9. (PMID: 14645112)
Nat Commun. 2018 Oct 10;9(1):4186. (PMID: 30305631)
FASEB J. 2013 Jun;27(6):2355-66. (PMID: 23482636)
Immunobiology. 2011 Jun;216(6):737-43. (PMID: 21074891)
J Virol. 2014 Aug;88(16):9442-57. (PMID: 24920807)
Immunobiology. 2015 Apr;220(4):467-75. (PMID: 25468721)
Front Immunol. 2015 May 26;6:257. (PMID: 26074922)
J Clin Invest. 2002 Apr;109(8):1057-63. (PMID: 11956243)
Nat Rev Immunol. 2009 Oct;9(10):729-40. (PMID: 19730437)
Nat Immunol. 2013 Feb;14(2):162-71. (PMID: 23263555)
PLoS One. 2016 Mar 31;11(3):e0152337. (PMID: 27031863)
Osteoarthritis Cartilage. 2005 Jan;13(1):34-8. (PMID: 15639635)
J Biomed Sci. 2015 Jul 22;22:58. (PMID: 26198107)
J Neurochem. 2011 Dec;119(5):1041-51. (PMID: 21929539)
Front Immunol. 2020 Sep 25;11:583135. (PMID: 33101310)
Gene Ther. 2004 Apr;11(8):694-700. (PMID: 14724669)
Front Immunol. 2020 Aug 18;11:1875. (PMID: 32973774)
Immunology. 1997 Jan;90(1):129-37. (PMID: 9038723)
Cell Transplant. 2020 Jan-Dec;29:963689720947102. (PMID: 32841048)
Reprod Biol. 2022 Dec;22(4):100700. (PMID: 36240670)
Case Reports Immunol. 2018 Oct 29;2018:7435870. (PMID: 30510820)
Int J Mol Sci. 2023 Jan 18;24(3):. (PMID: 36768217)
Am Fam Physician. 2009 Dec 1;80(11):1261-8. (PMID: 19961139)
Anim Reprod. 2013 Jan;10(1):3-15. (PMID: 25309630)
Biol Reprod. 1991 Jul;45(1):195-207. (PMID: 1878433)
Clin Exp Immunol. 1993 Apr;92(1):114-9. (PMID: 7682159)
J Biol Chem. 2012 May 25;287(22):18831-42. (PMID: 22451663)
J Immunol. 2019 Jul 1;203(1):3-5. (PMID: 31209141)
Int J STD AIDS. 2011 Jun;22(6):356-7. (PMID: 21680677)
Mol Immunol. 2009 Sep;46(14):2753-66. (PMID: 19477527)
J Biol Chem. 1981 Jul 25;256(14):7383-7. (PMID: 6788768)
Elife. 2017 Nov 24;6:. (PMID: 29171836)
J Immunol. 2018 Mar 15;200(6):2186-2198. (PMID: 29436411)
Hematol Oncol Clin North Am. 2015 Jun;29(3):409-27. (PMID: 26043382)
BMC Nephrol. 2016 Oct 18;17(1):148. (PMID: 27760523)
Mol Endocrinol. 1989 Apr;3(4):625-34. (PMID: 2725526)
Proc Natl Acad Sci U S A. 1993 Nov 1;90(21):10051-5. (PMID: 8234255)
Int J Mol Sci. 2014 Jun 13;15(6):10652-68. (PMID: 24933635)
Drug News Perspect. 2004 Sep;17(7):439-46. (PMID: 15514703)
Int Immunopharmacol. 2007 Dec 20;7(14):1909-23. (PMID: 18039528)
Immunol Rev. 2016 Nov;274(1):172-190. (PMID: 27782331)
Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12788-93. (PMID: 26420874)
Reprod Biol Endocrinol. 2010 Jan 05;8:1. (PMID: 20051099)
Curr Opin Organ Transplant. 2017 Dec;22(6):513-521. (PMID: 28901971)
Immunol Rev. 2018 Jan;281(1):8-27. (PMID: 29247995)
J Immunol. 2004 Nov 1;173(9):5540-5. (PMID: 15494503)
Annu Rev Immunol. 2003;21:29-70. (PMID: 12414723)
Am J Pathol. 2010 May;176(5):2378-84. (PMID: 20348246)
FASEB J. 2013 Dec;27(12):5083-93. (PMID: 23964079)
Int Immunopharmacol. 2007 Dec 20;7(14):1888-99. (PMID: 18039526)
Cell Transplant. 1993 Mar-Apr;2(2):123-9. (PMID: 8143079)
FASEB J. 2021 Mar;35(3):e21397. (PMID: 33565176)
Semin Cell Dev Biol. 2022 Jan;121:10-23. (PMID: 33910764)
J Biol Chem. 2010 Jan 15;285(3):2184-92. (PMID: 19920146)
J Immunol. 2006 Dec 15;177(12):8626-32. (PMID: 17142762)
Curr Opin Organ Transplant. 2012 Apr;17(2):162-7. (PMID: 22262106)
Nat Rev Immunol. 2007 Jan;7(1):9-18. (PMID: 17170757)
Front Immunol. 2015 Jun 02;6:262. (PMID: 26082779)
Nat Rev Immunol. 2015 Jun;15(6):388-400. (PMID: 25998963)
Immunochemistry. 1975 Dec;12(12):967-71. (PMID: 815171)
Front Immunol. 2015 May 26;6:263. (PMID: 26074923)
J Biol Chem. 2010 Mar 5;285(10):7633-44. (PMID: 20044484)
Tissue Antigens. 2004 Aug;64(2):111-8. (PMID: 15245366)
Cell Res. 2010 Jan;20(1):34-50. (PMID: 20010915)
J Immunol. 2006 Oct 15;177(8):5051-8. (PMID: 17015688)
J Am Soc Nephrol. 2009 Feb;20(2):289-98. (PMID: 19073822)
Hormones (Athens). 2015 Oct-Dec;14(4):504-14. (PMID: 26859601)
Front Oncol. 2021 Sep 14;11:736725. (PMID: 34595119)
J Immunol. 1981 May;126(5):1837-42. (PMID: 7217670)
Mol Hum Reprod. 2000 Nov;6(11):977-82. (PMID: 11044459)
J Innate Immun. 2015;7(4):333-9. (PMID: 25659340)
J Clin Invest. 2006 Oct;116(10):2817-26. (PMID: 17016562)
Immunology. 2015 Sep;146(1):130-43. (PMID: 26059553)
Diabetes. 1997 Feb;46(2):317-22. (PMID: 9000711)
Reprod Biol Endocrinol. 2015 Apr 26;13:37. (PMID: 25928197)
J Immunol. 1993 Aug 15;151(4):2159-65. (PMID: 8345200)
Xenotransplantation. 2003 Nov;10(6):577-86. (PMID: 14708526)
Annu Rev Immunol. 2005;23:821-52. (PMID: 15771587)
J Exp Med. 2005 May 16;201(10):1523-30. (PMID: 15883171)
Cell. 2006 Mar 10;124(5):915-27. (PMID: 16530040)
Front Immunol. 2022 Jan 17;12:771373. (PMID: 35111154)
Biol Reprod. 2004 Oct;71(4):1374-83. (PMID: 15215199)
J Immunol. 1998 Nov 15;161(10):5116-9. (PMID: 9820477)
Immunol Lett. 2021 Sep;237:42-57. (PMID: 34186155)
Hum Reprod. 2012 Jul;27(7):1985-93. (PMID: 22556378)
Crit Rev Immunol. 2012;32(6):463-88. (PMID: 23428224)
Trends Immunol. 2006 Feb;27(2):102-8. (PMID: 16406700)
Reprod Med Biol. 2019 Aug 29;19(1):24-31. (PMID: 31956282)
J Autoimmun. 2019 Nov;104:102314. (PMID: 31416681)
Reproduction. 2007 Dec;134(6):739-47. (PMID: 18042631)
Immunology. 2006 Jul;118(3):333-42. (PMID: 16827894)
Scand J Immunol. 2009 Oct;70(4):326-36. (PMID: 19751267)
Proc Natl Acad Sci U S A. 2019 Nov 26;116(48):24214-24220. (PMID: 31723045)
Semin Cell Dev Biol. 2014 Jun;30:36-44. (PMID: 24603046)
J Immunol. 2009 Dec 1;183(11):7371-8. (PMID: 19917686)
J Clin Invest. 2017 Mar 1;127(3):1046-1060. (PMID: 28218625)
Lab Invest. 1982 Dec;47(6):555-67. (PMID: 6755064)
J Reprod Immunol. 2017 Feb;119:107-112. (PMID: 27422223)
Front Cell Dev Biol. 2021 Feb 11;9:624025. (PMID: 33644062)
J Immunol. 1978 Jan;120(1):320-8. (PMID: 627722)
J Clin Invest. 1994 Jan;93(1):303-10. (PMID: 8282801)
Hum Reprod Update. 2018 Jul 1;24(4):416-441. (PMID: 29648649)
Reprod Sci. 2013 Sep;20(9):1075-82. (PMID: 23420828)
Eur Rev Med Pharmacol Sci. 2000 May-Jun;4(3):59-66. (PMID: 11558626)
J Clin Med. 2021 Jul 17;10(14):. (PMID: 34300323)
J Leukoc Biol. 2001 Nov;70(5):793-800. (PMID: 11698500)
Front Immunol. 2020 Sep 30;11:583304. (PMID: 33101311)
Immunity. 2001 Apr;14(4):357-68. (PMID: 11336681)
Immunodefic Rev. 1990;2(1):17-41. (PMID: 2164822)
Cell Mol Immunol. 2011 Jul;8(4):285-8. (PMID: 21258362)
Front Immunol. 2022 Jun 09;13:913502. (PMID: 35757731)
J Reprod Immunol. 2013 Apr;97(2):147-58. (PMID: 23415010)
Mol Immunol. 2014 Mar;58(1):98-107. (PMID: 24321396)
J Cereb Blood Flow Metab. 2014 Mar;34(3):369-75. (PMID: 24398940)
J Exp Med. 2009 Oct 26;206(11):2511-26. (PMID: 19822646)
J Immunol. 1985 Jul;135(1):440-4. (PMID: 3158705)
Immunol Rev. 2001 Apr;180:162-7. (PMID: 11414358)
Hum Reprod. 2015 Jul;30(7):1545-56. (PMID: 26003430)
Biol Reprod. 2005 May;72(5):1224-31. (PMID: 15659703)
J Leukoc Biol. 2017 Jan;101(1):193-204. (PMID: 27581539)
J Immunol. 1994 Aug 15;153(4):1430-40. (PMID: 8046223)
Curr Opin Immunol. 2003 Oct;15(5):487-92. (PMID: 14499254)
Cell Immunol. 2018 Aug;330:120-125. (PMID: 29650243)
Cell Transplant. 2016 Nov;25(11):2027-2040. (PMID: 27305664)
Cell Tissue Res. 2011 Jan;343(1):227-35. (PMID: 20838815)
Med Mol Morphol. 2012 Dec;45(4):185-9. (PMID: 23224596)
Blood. 2015 Feb 5;125(6):1034-7. (PMID: 25395424)
Nat Commun. 2019 Oct 11;10(1):4626. (PMID: 31604923)
Nat Immunol. 2013 Feb;14(2):110-2. (PMID: 23334823)
J Immunol. 2003 Jan 15;170(2):788-94. (PMID: 12517942)
J Immunol. 2004 Apr 1;172(7):4381-90. (PMID: 15034053)
Am J Transplant. 2009 Aug;9(8):1784-95. (PMID: 19563342)
Clin Exp Immunol. 2011 Jun;164(3):301-11. (PMID: 21488871)
J Korean Med Sci. 2007 Apr;22(2):277-82. (PMID: 17449937)
FASEB J. 2013 Mar;27(3):855-64. (PMID: 23239822)
Vitam Horm. 2011;85:255-97. (PMID: 21353885)
Mol Hum Reprod. 1996 Nov;2(11):859-66. (PMID: 9237226)
Mol Cell Biol. 2003 Apr;23(7):2614-22. (PMID: 12640142)
Endocr Rev. 2015 Oct;36(5):564-91. (PMID: 26357922)
Int J Androl. 2009 Jun;32(3):255-64. (PMID: 18179560)
Transplant Proc. 2008 Dec;40(10):3289-93. (PMID: 19100374)
Nat Commun. 2016 Aug 24;7:12623. (PMID: 27554168)
Osteoarthritis Cartilage. 2002 Sep;10(9):707-13. (PMID: 12202123)
Clin Oncol (R Coll Radiol). 1998;10(6):401-3. (PMID: 9890544)
Int J Mol Sci. 2022 Oct 23;23(21):. (PMID: 36361551)
J Thromb Haemost. 2018 May;16(5):991-1002. (PMID: 29383821)
Front Immunol. 2019 Oct 04;10:2380. (PMID: 31636644)
Int J Mol Sci. 2017 Dec 29;19(1):. (PMID: 29286292)
Immunopharmacology. 2000 Mar;46(3):209-22. (PMID: 10741901)
Front Immunol. 2019 Mar 06;10:360. (PMID: 30894857)
Andrologia. 1999 Sep;31(5):308-10. (PMID: 10526645)
Sci Rep. 2019 Nov 4;9(1):15919. (PMID: 31685866)
J Thorac Cardiovasc Surg. 2002 Apr;123(4):803-9. (PMID: 11986610)
J Immunol. 2017 Jun 1;198(11):4327-4340. (PMID: 28461571)
J Invest Dermatol. 1989 Feb;92(2):184-9. (PMID: 2493055)
Biol Reprod. 2012 Jan 10;86(1):1-14. (PMID: 21900683)
Front Immunol. 2019 Apr 04;10:712. (PMID: 31019517)
معلومات مُعتمدة: N/A CH Foundation
فهرسة مساهمة: Keywords: Sertoli cells; complement; immune regulation; testicular immune privilege
المشرفين على المادة: 9007-36-7 (Complement System Proteins)
تواريخ الأحداث: Date Created: 20230225 Date Completed: 20230228 Latest Revision: 20230301
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9965741
DOI: 10.3390/ijms24043371
PMID: 36834786
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms24043371