دورية أكاديمية
أعرض في EDS

Circulating Cell-Free DNA Levels in Psychiatric Diseases: A Systematic Review and Meta-Analysis.

التفاصيل البيبلوغرافية
العنوان: Circulating Cell-Free DNA Levels in Psychiatric Diseases: A Systematic Review and Meta-Analysis.
المؤلفون: Melamud MM; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia., Buneva VN; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.; Department of Natural Sciences, Novosibirsk State University, 630090 Novosibirsk, Russia., Ermakov EA; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.; Department of Natural Sciences, Novosibirsk State University, 630090 Novosibirsk, Russia.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2023 Feb 08; Vol. 24 (4). Date of Electronic Publication: 2023 Feb 08.
نوع المنشور: Meta-Analysis; Systematic Review; Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Mental Disorders* , Bipolar Disorder*/genetics , Cell-Free Nucleic Acids* , Schizophrenia*/genetics, Humans ; DNA, Mitochondrial
مستخلص: The cell-free DNA (cfDNA) levels are known to increase in biological fluids in various pathological conditions. However, the data on circulating cfDNA in severe psychiatric disorders, including schizophrenia, bipolar disorder (BD), and depressive disorders (DDs), is contradictory. This meta-analysis aimed to analyze the concentrations of different cfDNA types in schizophrenia, BD, and DDs compared with healthy donors. The mitochondrial (cf-mtDNA), genomic (cf-gDNA), and total cfDNA concentrations were analyzed separately. The effect size was estimated using the standardized mean difference (SMD). Eight reports for schizophrenia, four for BD, and five for DDs were included in the meta-analysis. However, there were only enough data to analyze the total cfDNA and cf-gDNA in schizophrenia and cf-mtDNA in BD and DDs. It has been shown that the levels of total cfDNA and cf-gDNA in patients with schizophrenia are significantly higher than in healthy donors (SMD values of 0.61 and 0.6, respectively; p < 0.00001). Conversely, the levels of cf-mtDNA in BD and DDs do not differ compared with healthy individuals. Nevertheless, further research is needed in the case of BD and DDs due to the small sample sizes in the BD studies and the significant data heterogeneity in the DD studies. Additionally, further studies are needed on cf-mtDNA in schizophrenia or cf-gDNA and total cfDNA in BD and DDs due to insufficient data. In conclusion, this meta-analysis provides the first evidence of increases in total cfDNA and cf-gDNA in schizophrenia but shows no changes in cf-mtDNA in BD and DDs. Increased circulating cfDNA in schizophrenia may be associated with chronic systemic inflammation, as cfDNA has been found to trigger inflammatory responses.
References: Mutat Res. 2013 Jul-Aug;747-748:6-18. (PMID: 23644378)
Expert Opin Biol Ther. 2012 Jun;12 Suppl 1:S99-111. (PMID: 22594608)
Eur J Hum Genet. 2018 Jul;26(7):937-945. (PMID: 29681621)
Pharmacol Res. 2021 Jan;163:105325. (PMID: 33278569)
Sci Transl Med. 2014 Jun 18;6(241):241ra77. (PMID: 24944192)
World J Biol Psychiatry. 2020 Jun;21(5):326-338. (PMID: 30806142)
PLoS One. 2022 Jun 13;17(6):e0269130. (PMID: 35696356)
J Affect Disord. 2018 Jun;233:15-20. (PMID: 28633757)
BMJ. 2003 Sep 6;327(7414):557-60. (PMID: 12958120)
Front Immunol. 2021 Feb 11;11:624597. (PMID: 33643304)
Am J Psychiatry. 2004 Jan;161(1):109-15. (PMID: 14702258)
Clin Chem. 2019 May;65(5):623-633. (PMID: 30792266)
Schizophr Res. 2013 Oct;150(1):245-51. (PMID: 23953827)
Mutat Res. 2015 Sep;779:1-15. (PMID: 26113293)
Front Psychiatry. 2021 Mar 30;12:637789. (PMID: 33859582)
J Psychiatr Res. 2014 Jan;48(1):94-101. (PMID: 24128664)
Trends Mol Med. 2020 May;26(5):519-528. (PMID: 32359482)
Mech Ageing Dev. 2011 Jan-Feb;132(1-2):20-6. (PMID: 21078336)
Transl Psychiatry. 2016 Dec 6;6(12):e971. (PMID: 27922635)
Transl Psychiatry. 2018 May 22;8(1):104. (PMID: 29795286)
Front Psychiatry. 2022 Apr 25;13:880568. (PMID: 35546942)
Nat Rev Immunol. 2020 Feb;20(2):95-112. (PMID: 31558839)
Front Psychiatry. 2020 Jan 21;10:992. (PMID: 32038328)
J Psychiatr Res. 2017 Apr;87:15-22. (PMID: 27987480)
Hum Genet. 2021 Apr;140(4):565-578. (PMID: 33123832)
Genes (Basel). 2022 Mar 20;13(3):. (PMID: 35328103)
Elife. 2022 Jun 14;11:. (PMID: 35699419)
J Affect Disord. 2022 Feb 15;299:644-651. (PMID: 34715189)
Mitochondrion. 2021 Jul;59:225-245. (PMID: 33839318)
Biometrics. 1994 Dec;50(4):1088-101. (PMID: 7786990)
BMJ. 2021 Mar 29;372:n71. (PMID: 33782057)
J Psychiatr Res. 2021 Jul;139:25-29. (PMID: 34022472)
World J Biol Psychiatry. 2023 Jan;24(1):58-69. (PMID: 35532037)
Blood. 2013 Oct 17;122(16):2784-94. (PMID: 24009232)
Immunity. 2020 Jul 14;53(1):54-77. (PMID: 32668228)
J Psychiatr Res. 2020 Apr;123:187-193. (PMID: 32078836)
Front Immunol. 2019 Mar 19;10:502. (PMID: 30941136)
Int J Genomics. 2019 Aug 05;2019:8390585. (PMID: 31467866)
Oxid Med Cell Longev. 2015;2015:782123. (PMID: 26273425)
Oxid Med Cell Longev. 2021 Jan 23;2021:8881770. (PMID: 33552387)
Nat Rev Immunol. 2016 Jan;16(1):22-34. (PMID: 26711676)
BMJ. 1997 Sep 13;315(7109):629-34. (PMID: 9310563)
BMC Med Res Methodol. 2018 Mar 7;18(1):25. (PMID: 29514597)
PLoS One. 2017 Aug 29;12(8):e0183915. (PMID: 28850588)
Science. 2021 Apr 9;372(6538):. (PMID: 33833097)
C R Seances Soc Biol Fil. 1948 Feb;142(3-4):241-3. (PMID: 18875018)
Schizophr Bull. 2021 Mar 16;47(2):530-541. (PMID: 32971537)
Neuropsychopharmacology. 2018 Jun;43(7):1557-1564. (PMID: 29453441)
Am J Hum Genet. 2019 Dec 5;105(6):1091-1101. (PMID: 31708118)
J Neuroinflammation. 2020 Jul 16;17(1):212. (PMID: 32677958)
World J Biol Psychiatry. 2022 Feb;23(2):87-102. (PMID: 34096821)
Cell Oncol (Dordr). 2019 Feb;42(1):13-28. (PMID: 30367445)
Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14055-60. (PMID: 21844380)
BMJ. 2021 Mar 29;372:n160. (PMID: 33781993)
Cell. 2016 Jun 30;166(1):88-101. (PMID: 27293190)
Biol Rev Camb Philos Soc. 2018 Aug;93(3):1649-1683. (PMID: 29654714)
Schizophr Res. 2019 Apr;206:4-12. (PMID: 30573407)
Front Psychiatry. 2021 Jul 07;12:652314. (PMID: 34305669)
PLoS One. 2021 Nov 4;16(11):e0259591. (PMID: 34735532)
Nat Commun. 2018 Nov 29;9(1):5068. (PMID: 30498206)
Annu Rev Pathol. 2020 Jan 24;15:493-518. (PMID: 31675482)
Front Immunol. 2021 Feb 26;12:629922. (PMID: 33717156)
Acta Psychiatr Scand. 2015 Sep;132(3):211-7. (PMID: 25891376)
Int J Mol Sci. 2020 Oct 29;21(21):. (PMID: 33137955)
Acta Psychiatr Scand. 2020 Jul;142(1):18-26. (PMID: 31850530)
J Psychiatr Res. 2021 Jun;138:380-387. (PMID: 33957300)
معلومات مُعتمدة: 21-75-00102 Russian Science Foundation
فهرسة مساهمة: Keywords: DAMPs; bipolar disorder; cf-mtDNA; cfDNA; inflammation; major depressive disorder; schizophrenia
المشرفين على المادة: 0 (Cell-Free Nucleic Acids)
0 (DNA, Mitochondrial)
تواريخ الأحداث: Date Created: 20230225 Date Completed: 20230228 Latest Revision: 20230301
رمز التحديث: 20230301
مُعرف محوري في PubMed: PMC9963116
DOI: 10.3390/ijms24043402
PMID: 36834811
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms24043402