دورية أكاديمية
أعرض في EDS

In Vitro Anti-Inflammatory and Antioxidant Activities of pH-Responsive Resveratrol-Urocanic Acid Nano-Assemblies.

التفاصيل البيبلوغرافية
العنوان: In Vitro Anti-Inflammatory and Antioxidant Activities of pH-Responsive Resveratrol-Urocanic Acid Nano-Assemblies.
المؤلفون: Song H; Department of Systems Biotechnology, Chung-Ang University, Anseong 17546, Republic of Korea., Kang S; Department of Physical Medicine and Rehabilitation and Nano-Based Disease Control Institute, Korea University Guro Hospital, #148, Gurodong-ro, Guro-gu, Seoul 08308, Republic of Korea., Yu Y; Department of Orthopedic Surgery and Nano-Based Disease Control Institute, Korea University Guro Hospital, #148, Gurodong-ro, Guro-gu, Seoul 08308, Republic of Korea., Jung SY; Department of Systems Biotechnology, Chung-Ang University, Anseong 17546, Republic of Korea., Park K; Department of Systems Biotechnology, Chung-Ang University, Anseong 17546, Republic of Korea., Kim SM; Department of Orthopedic Surgery and Nano-Based Disease Control Institute, Korea University Guro Hospital, #148, Gurodong-ro, Guro-gu, Seoul 08308, Republic of Korea., Kim HJ; Department of Orthopedic Surgery and Nano-Based Disease Control Institute, Korea University Guro Hospital, #148, Gurodong-ro, Guro-gu, Seoul 08308, Republic of Korea., Kim JG; Department of Orthopedic Surgery, Korea University College of Medicine, Korea University Ansan Hospital, 123, Jeokgeum-ro, Danwon-gu, Ansan-si 15355, Republic of Korea., Kim SE; Department of Orthopedic Surgery and Nano-Based Disease Control Institute, Korea University Guro Hospital, #148, Gurodong-ro, Guro-gu, Seoul 08308, Republic of Korea.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2023 Feb 14; Vol. 24 (4). Date of Electronic Publication: 2023 Feb 14.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Anti-Inflammatory Agents*/chemistry , Anti-Inflammatory Agents*/pharmacology , Antioxidants*/chemistry , Antioxidants*/pharmacology , Resveratrol*/chemistry , Resveratrol*/pharmacology , Urocanic Acid*/chemistry , Urocanic Acid*/pharmacology , Nanoparticles*, Humans ; Cyclooxygenase 2/metabolism ; Hydrogen-Ion Concentration ; Inflammation/metabolism ; Lipopolysaccharides ; Nitric Oxide/metabolism ; Nitric Oxide Synthase Type II/metabolism ; Reactive Oxygen Species/metabolism ; Spectroscopy, Fourier Transform Infrared ; Tumor Necrosis Factor-alpha/metabolism
مستخلص: Inflammatory environments provide vital biochemical stimuli (i.e., oxidative stress, pH, and enzymes) for triggered drug delivery in a controlled manner. Inflammation alters the local pH within the affected tissues. As a result, pH-sensitive nanomaterials can be used to effectively target drugs to the site of inflammation. Herein, we designed pH-sensitive nanoparticles in which resveratrol (an anti-inflammatory and antioxidant compound (RES)) and urocanic acid (UA) were complexed with a pH-sensitive moiety using an emulsion method. These RES-UA NPs were characterized by transmission electron microscopy, dynamic light scattering, zeta potential, and FT-IR spectroscopy. The anti-inflammatory and antioxidant activities of the RES-UA NPs were assessed in RAW 264.7 macrophages. The NPs were circular in shape and ranged in size from 106 to 180 nm. The RES-UA NPs suppressed the mRNA expression of the pro-inflammatory molecules inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α) in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages in a concentration-dependent manner. Incubation of LPS-stimulated macrophages with RES-UA NPs reduced the generation of reactive oxygen species (ROS) in a concentration-dependent manner. These results suggest that pH-responsive RES-UA NPs can be used to decrease ROS generation and inflammation.
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معلومات مُعتمدة: NRF-2019R1G1A1100534 National Research Foundation of Korea; NRF-2020R1G1A1013774 National Research Foundation of Korea; K2110241 Korea University grants
فهرسة مساهمة: Keywords: anti-inflammatory; antioxidant; nanoparticles; pH responsive; resveratrol; urocanic acid
المشرفين على المادة: 0 (Anti-Inflammatory Agents)
0 (Antioxidants)
EC 1.14.99.1 (Cyclooxygenase 2)
0 (Lipopolysaccharides)
31C4KY9ESH (Nitric Oxide)
EC 1.14.13.39 (Nitric Oxide Synthase Type II)
0 (Reactive Oxygen Species)
Q369O8926L (Resveratrol)
0 (Tumor Necrosis Factor-alpha)
G8D26XJJ3B (Urocanic Acid)
تواريخ الأحداث: Date Created: 20230225 Date Completed: 20230324 Latest Revision: 20230324
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9965382
DOI: 10.3390/ijms24043843
PMID: 36835253
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms24043843