دورية أكاديمية
In Vitro Anti-Inflammatory and Antioxidant Activities of pH-Responsive Resveratrol-Urocanic Acid Nano-Assemblies.
العنوان: | In Vitro Anti-Inflammatory and Antioxidant Activities of pH-Responsive Resveratrol-Urocanic Acid Nano-Assemblies. |
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المؤلفون: | Song H; Department of Systems Biotechnology, Chung-Ang University, Anseong 17546, Republic of Korea., Kang S; Department of Physical Medicine and Rehabilitation and Nano-Based Disease Control Institute, Korea University Guro Hospital, #148, Gurodong-ro, Guro-gu, Seoul 08308, Republic of Korea., Yu Y; Department of Orthopedic Surgery and Nano-Based Disease Control Institute, Korea University Guro Hospital, #148, Gurodong-ro, Guro-gu, Seoul 08308, Republic of Korea., Jung SY; Department of Systems Biotechnology, Chung-Ang University, Anseong 17546, Republic of Korea., Park K; Department of Systems Biotechnology, Chung-Ang University, Anseong 17546, Republic of Korea., Kim SM; Department of Orthopedic Surgery and Nano-Based Disease Control Institute, Korea University Guro Hospital, #148, Gurodong-ro, Guro-gu, Seoul 08308, Republic of Korea., Kim HJ; Department of Orthopedic Surgery and Nano-Based Disease Control Institute, Korea University Guro Hospital, #148, Gurodong-ro, Guro-gu, Seoul 08308, Republic of Korea., Kim JG; Department of Orthopedic Surgery, Korea University College of Medicine, Korea University Ansan Hospital, 123, Jeokgeum-ro, Danwon-gu, Ansan-si 15355, Republic of Korea., Kim SE; Department of Orthopedic Surgery and Nano-Based Disease Control Institute, Korea University Guro Hospital, #148, Gurodong-ro, Guro-gu, Seoul 08308, Republic of Korea. |
المصدر: | International journal of molecular sciences [Int J Mol Sci] 2023 Feb 14; Vol. 24 (4). Date of Electronic Publication: 2023 Feb 14. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI, [2000- |
مواضيع طبية MeSH: | Anti-Inflammatory Agents*/chemistry , Anti-Inflammatory Agents*/pharmacology , Antioxidants*/chemistry , Antioxidants*/pharmacology , Resveratrol*/chemistry , Resveratrol*/pharmacology , Urocanic Acid*/chemistry , Urocanic Acid*/pharmacology , Nanoparticles*, Humans ; Cyclooxygenase 2/metabolism ; Hydrogen-Ion Concentration ; Inflammation/metabolism ; Lipopolysaccharides ; Nitric Oxide/metabolism ; Nitric Oxide Synthase Type II/metabolism ; Reactive Oxygen Species/metabolism ; Spectroscopy, Fourier Transform Infrared ; Tumor Necrosis Factor-alpha/metabolism |
مستخلص: | Inflammatory environments provide vital biochemical stimuli (i.e., oxidative stress, pH, and enzymes) for triggered drug delivery in a controlled manner. Inflammation alters the local pH within the affected tissues. As a result, pH-sensitive nanomaterials can be used to effectively target drugs to the site of inflammation. Herein, we designed pH-sensitive nanoparticles in which resveratrol (an anti-inflammatory and antioxidant compound (RES)) and urocanic acid (UA) were complexed with a pH-sensitive moiety using an emulsion method. These RES-UA NPs were characterized by transmission electron microscopy, dynamic light scattering, zeta potential, and FT-IR spectroscopy. The anti-inflammatory and antioxidant activities of the RES-UA NPs were assessed in RAW 264.7 macrophages. The NPs were circular in shape and ranged in size from 106 to 180 nm. The RES-UA NPs suppressed the mRNA expression of the pro-inflammatory molecules inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α) in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages in a concentration-dependent manner. Incubation of LPS-stimulated macrophages with RES-UA NPs reduced the generation of reactive oxygen species (ROS) in a concentration-dependent manner. These results suggest that pH-responsive RES-UA NPs can be used to decrease ROS generation and inflammation. |
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معلومات مُعتمدة: | NRF-2019R1G1A1100534 National Research Foundation of Korea; NRF-2020R1G1A1013774 National Research Foundation of Korea; K2110241 Korea University grants |
فهرسة مساهمة: | Keywords: anti-inflammatory; antioxidant; nanoparticles; pH responsive; resveratrol; urocanic acid |
المشرفين على المادة: | 0 (Anti-Inflammatory Agents) 0 (Antioxidants) EC 1.14.99.1 (Cyclooxygenase 2) 0 (Lipopolysaccharides) 31C4KY9ESH (Nitric Oxide) EC 1.14.13.39 (Nitric Oxide Synthase Type II) 0 (Reactive Oxygen Species) Q369O8926L (Resveratrol) 0 (Tumor Necrosis Factor-alpha) G8D26XJJ3B (Urocanic Acid) |
تواريخ الأحداث: | Date Created: 20230225 Date Completed: 20230324 Latest Revision: 20230324 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC9965382 |
DOI: | 10.3390/ijms24043843 |
PMID: | 36835253 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1422-0067 |
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DOI: | 10.3390/ijms24043843 |