دورية أكاديمية
أعرض في EDS

Comparative Genomics of Histoplasma capsulatum and Prediction of New Vaccines and Drug Targets.

التفاصيل البيبلوغرافية
العنوان: Comparative Genomics of Histoplasma capsulatum and Prediction of New Vaccines and Drug Targets.
المؤلفون: Almeida PCS; Program of Multi-Professional Residence, Federal University of Triangulo Mineiro, Uberaba 38025-440, Brazil., Roque BS; Program of Multi-Professional Residence, Federal University of Triangulo Mineiro, Uberaba 38025-440, Brazil., Felice AG; Post-Graduate Program in Tropical Medicine and Infectology, Federal University of Triangulo Mineiro, Uberaba 38025-440, Brazil., Jaiswal AK; Post-Graduate Program in Bioinformatics, Federal University of Minas Gerais, Belo Horizonte 31270-901, Brazil., Tiwari S; Post-Graduate Program in Microbiology, Institute of Biology, Federal University of Bahia, Salvador 40170-110, Brazil.; Post-Graduate Program in Immunology, Institute of Health Sciences, Federal University of Bahia, Salvador 40231-300, Brazil., Azevedo V; Department of Genetics, Ecology and Evolution, Federal University of Minas Gerais, Belo Horizonte 31270-901, Brazil., Silva-Vergara ML; Department of Infectious Diseases, Federal University of Triangulo Mineiro, Uberaba 38025-440, Brazil., de Castro Soares S; Department of Microbiology, Immunology and Parasitology, Federal University of Triangulo Mineiro, Uberaba 38015-05, Brazil., Ferreira-Paim K; Program of Multi-Professional Residence, Federal University of Triangulo Mineiro, Uberaba 38025-440, Brazil.; Department of Microbiology, Immunology and Parasitology, Federal University of Triangulo Mineiro, Uberaba 38015-05, Brazil., Fonseca FM; Program of Multi-Professional Residence, Federal University of Triangulo Mineiro, Uberaba 38025-440, Brazil.; Department of Biomedicine, Federal University of Triangulo Mineiro, Uberaba 38025-350, Brazil.
المصدر: Journal of fungi (Basel, Switzerland) [J Fungi (Basel)] 2023 Feb 02; Vol. 9 (2). Date of Electronic Publication: 2023 Feb 02.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101671827 Publication Model: Electronic Cited Medium: Internet ISSN: 2309-608X (Electronic) Linking ISSN: 2309608X NLM ISO Abbreviation: J Fungi (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2015]-
مستخلص: Histoplasma capsulatum is a thermodymorphic fungus that causes histoplasmosis, a systemic mycosis that presents different clinical manifestations, ranging from self-limiting to acute lung infection, chronic lung infection and disseminated infection. Usually, it affects severely immunocompromised patients although immunocompetent patients can also be infected. Currently, there are no vaccines to prevent histoplasmosis and the available antifungal treatment presents moderate to high toxicity. Additionally, there are few options of antifungal drugs. Thus, the aim of this study was to predict possible protein targets for the construction of potential vaccine candidates and predict potential drug targets against H. capsulatum . Whole genome sequences from four previously published H. capsulatum strains were analyzed and submitted to different bioinformatic approaches such as reverse vaccinology and subtractive genomics. A total of four proteins were characterized as good protein candidates (vaccine antigens) for vaccine development, three of which are membrane-bound and one is secreted. In addition, it was possible to predict four cytoplasmic proteins which were classified as good protein candidates and, through molecular docking performed for each identified target, we found four natural compounds that showed favorable interactions with our target proteins. Our study can help in the development of potential vaccines and new drugs that can change the current scenario of the treatment and prevention of histoplasmosis.
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فهرسة مساهمة: Keywords: Histoplasma capsulatum; beta-1,3-glucanosyltransferase; comparative genomics; drug target; histoplasmosis; neglected fungal diseases; reverse vaccinology
تواريخ الأحداث: Date Created: 20230225 Latest Revision: 20230301
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9963733
DOI: 10.3390/jof9020193
PMID: 36836308
قاعدة البيانات: MEDLINE
الوصف
تدمد:2309-608X
DOI:10.3390/jof9020193