دورية أكاديمية
أعرض في EDS

Characteristics and Outcomes of Liver Transplantation Recipients after Tranexamic Acid Treatment and Platelet Transfusion: A Retrospective Single-Centre Experience.

التفاصيل البيبلوغرافية
العنوان: Characteristics and Outcomes of Liver Transplantation Recipients after Tranexamic Acid Treatment and Platelet Transfusion: A Retrospective Single-Centre Experience.
المؤلفون: Alsabani MH; Anesthesia Technology Department, College of Applied Medical Sciences, King Saud bin Abdulaziz University for Health Sciences, Riyadh 11481, Saudi Arabia.; King Abdullah International Medical Research Centre, Riyadh 11481, Saudi Arabia., Sibai A; King Abdullah International Medical Research Centre, Riyadh 11481, Saudi Arabia.; Department of Anesthesia, Ministry of National Guard Health Affairs, Riyadh 11426, Saudi Arabia.; College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh 11481, Saudi Arabia., Alharbi SF; Anesthesia Technology Department, College of Applied Medical Sciences, King Saud bin Abdulaziz University for Health Sciences, Riyadh 11481, Saudi Arabia.; King Abdullah International Medical Research Centre, Riyadh 11481, Saudi Arabia., Olayan LH; Anesthesia Technology Department, College of Applied Medical Sciences, King Saud bin Abdulaziz University for Health Sciences, Riyadh 11481, Saudi Arabia.; King Abdullah International Medical Research Centre, Riyadh 11481, Saudi Arabia., Samman AA; Anesthesia Technology Department, College of Applied Medical Sciences, King Saud bin Abdulaziz University for Health Sciences, Riyadh 11481, Saudi Arabia.; King Abdullah International Medical Research Centre, Riyadh 11481, Saudi Arabia., Al Harbi MK; King Abdullah International Medical Research Centre, Riyadh 11481, Saudi Arabia.; Department of Anesthesia, Ministry of National Guard Health Affairs, Riyadh 11426, Saudi Arabia.; College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh 11481, Saudi Arabia.
المصدر: Medicina (Kaunas, Lithuania) [Medicina (Kaunas)] 2023 Jan 23; Vol. 59 (2). Date of Electronic Publication: 2023 Jan 23.
نوع المنشور: Journal Article; Observational Study
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 9425208 Publication Model: Electronic Cited Medium: Internet ISSN: 1648-9144 (Electronic) Linking ISSN: 1010660X NLM ISO Abbreviation: Medicina (Kaunas) Subsets: MEDLINE
أسماء مطبوعة: Publication: 2018- : Basel, Switzerland : MDPI
Original Publication: Kaunas : Lietuvos gydytojų sąjunga
مواضيع طبية MeSH: Antifibrinolytic Agents*/therapeutic use , Liver Transplantation* , Thrombosis* , Tranexamic Acid*/therapeutic use, Humans ; Blood Loss, Surgical/prevention & control ; Cohort Studies ; Platelet Transfusion ; Retrospective Studies ; Treatment Outcome
مستخلص: Background and Objectives : Patients undergoing liver transplantation (LT) often require increased blood product transfusion due to pre-existing coagulopathy and intraoperative fibrinolysis. Strategies to minimise intraoperative bleeding and subsequent blood product requirements include platelet transfusion and tranexamic acid (TXA). Prophylactic TXA administration has been shown to reduce bleeding and blood product requirements intraoperatively. However, its clinical use is still debated. The aim of this study was to report on a single-centre practice and analyse clinical characteristics and outcomes of LT recipients according to intraoperative treatment of TXA or platelet transfusion. Materials and Methods : This was a retrospective observational cohort study in which we reviewed 162 patients' records. Characteristics, intraoperative requirement of blood products, postoperative development of thrombosis and outcomes were compared between patients without or with intraoperative TXA treatment and without or with platelet transfusion. Results : Intraoperative treatment of TXA and platelets was 53% and 57.40%, respectively. Patients who required intraoperative administration of TXA or platelet transfusion also required more transfusion of blood products. Neither TXA nor platelet transfusion were associated with increased postoperative development of hepatic artery and portal vein thrombosis, 90-day mortality or graft loss. There was a significant increase in the median length of intensive care unit (ICU) stay in those who received platelet transfusion only (2.00 vs. 3.00 days; p = 0.021). Time to extubate was significantly different in both those who required TXA and platelet transfusion intraoperatively. Conclusions : Our analysis indicates that LT recipients still required copious intraoperative transfusion of blood products, despite the use of intraoperative TXA and platelets. Our findings have important implications for current transfusion practice in LT recipients and may guide clinicians to act upon these findings, which will support global efforts to encourage a wider use of TXA to reduce transfusion requirements, including platelets.
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فهرسة مساهمة: Keywords: blood product transfusion; hepatic artery thrombosis; liver transplantation; platelet transfusion; portal vein thrombosis; postoperative complications; tranexamic acid
المشرفين على المادة: 0 (Antifibrinolytic Agents)
6T84R30KC1 (Tranexamic Acid)
تواريخ الأحداث: Date Created: 20230225 Date Completed: 20230313 Latest Revision: 20230313
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9961269
DOI: 10.3390/medicina59020219
PMID: 36837421
قاعدة البيانات: MEDLINE
الوصف
تدمد:1648-9144
DOI:10.3390/medicina59020219