دورية أكاديمية
أعرض في EDS

Effects of Hydroxytyrosol in Endothelial Functioning: A Comprehensive Review.

التفاصيل البيبلوغرافية
العنوان: Effects of Hydroxytyrosol in Endothelial Functioning: A Comprehensive Review.
المؤلفون: Vijakumaran U; Centre for Tissue Engineering & Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Cheras, Kuala Lumpur 56000, Malaysia., Shanmugam J; Centre for Tissue Engineering & Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Cheras, Kuala Lumpur 56000, Malaysia., Heng JW; Centre for Tissue Engineering & Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Cheras, Kuala Lumpur 56000, Malaysia., Azman SS; Centre for Tissue Engineering & Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Cheras, Kuala Lumpur 56000, Malaysia., Yazid MD; Centre for Tissue Engineering & Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Cheras, Kuala Lumpur 56000, Malaysia., Haizum Abdullah NA; Centre for Tissue Engineering & Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Cheras, Kuala Lumpur 56000, Malaysia., Sulaiman N; Centre for Tissue Engineering & Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Cheras, Kuala Lumpur 56000, Malaysia.
المصدر: Molecules (Basel, Switzerland) [Molecules] 2023 Feb 16; Vol. 28 (4). Date of Electronic Publication: 2023 Feb 16.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c1995-
مواضيع طبية MeSH: Phenylethyl Alcohol*/pharmacology , Olea*, Olive Oil/pharmacology ; Endothelial Cells ; Antioxidants/pharmacology
مستخلص: Pharmacologists have been emphasizing and applying plant and herbal-based treatments in vascular diseases for decades now. Olives, for example, are a traditional symbol of the Mediterranean diet. Hydroxytyrosol is an olive-derived compound known for its antioxidant and cardioprotective effects. Acknowledging the merit of antioxidants in maintaining endothelial function warrants the application of hydroxytyrosol in endothelial dysfunction salvage and recovery. Endothelial dysfunction (ED) is an impairment of endothelial cells that adversely affects vascular homeostasis. Disturbance in endothelial functioning is a known precursor for atherosclerosis and, subsequently, coronary and peripheral artery disease. However, the effects of hydroxytyrosol on endothelial functioning were not extensively studied, limiting its value either as a nutraceutical supplement or in clinical trials. The action of hydroxytyrosol in endothelial functioning at a cellular and molecular level is gathered and summarized in this review. The favorable effects of hydroxytyrosol in the improvement of endothelial functioning from in vitro and in vivo studies were scrutinized. We conclude that hydroxytyrosol is capable to counteract oxidative stress, inflammation, vascular aging, and arterial stiffness; thus, it is beneficial to preserve endothelial function both in vitro and in vivo. Although not specifically for endothelial dysfunction, hydroxytyrosol safety and efficacy had been demonstrated via in vivo and clinical trials for cardiovascular-related studies.
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معلومات مُعتمدة: FRGS/1/2019/SKK08/UKM/03/3 Ministry of Higher Education, Malaysia
فهرسة مساهمة: Keywords: antioxidant; cardiovascular diseases; endothelial cells; endothelial functioning; hydroxytyrosol; olive
المشرفين على المادة: 10597-60-1 (3,4-dihydroxyphenylethanol)
0 (Olive Oil)
0 (Antioxidants)
ML9LGA7468 (Phenylethyl Alcohol)
تواريخ الأحداث: Date Created: 20230225 Date Completed: 20230228 Latest Revision: 20230301
رمز التحديث: 20230301
مُعرف محوري في PubMed: PMC9966213
DOI: 10.3390/molecules28041861
PMID: 36838850
قاعدة البيانات: MEDLINE
الوصف
تدمد:1420-3049
DOI:10.3390/molecules28041861