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Evaluation of Therapeutic Efficacy and Imaging Capabilities of 153 Sm 2 O 3 -Loaded Polystyrene Microspheres for Intra-Tumoural Radionuclide Therapy of Liver Cancer Using Sprague-Dawley Rat Model.

التفاصيل البيبلوغرافية
العنوان: Evaluation of Therapeutic Efficacy and Imaging Capabilities of 153 Sm 2 O 3 -Loaded Polystyrene Microspheres for Intra-Tumoural Radionuclide Therapy of Liver Cancer Using Sprague-Dawley Rat Model.
المؤلفون: Tan HY; School of Biosciences, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya 47500, Malaysia., Wong YH; School of Medicine, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya 47500, Malaysia.; Medical Advancement for Better Quality of Life Impact Lab, Taylor's University, Subang Jaya 47500, Malaysia., Kasbollah A; Medical Technology Division, Malaysian Nuclear Agency, Bangi 43000, Malaysia., Md Shah MN; Department of Biomedical Imaging, University of Malaya Medical Centre, Kuala Lumpur 59100, Malaysia., Yahya N; Diagnostic Imaging and Radiotherapy Programme, Faculty of Health Sciences, National University of Malaysia, Kuala Lumpur 50300, Malaysia., Abdullah BJJ; School of Medicine, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya 47500, Malaysia.; Department of Biomedical Imaging, University of Malaya Medical Centre, Kuala Lumpur 59100, Malaysia., Yeong CH; School of Medicine, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya 47500, Malaysia.; Medical Advancement for Better Quality of Life Impact Lab, Taylor's University, Subang Jaya 47500, Malaysia.
المصدر: Pharmaceutics [Pharmaceutics] 2023 Feb 06; Vol. 15 (2). Date of Electronic Publication: 2023 Feb 06.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101534003 Publication Model: Electronic Cited Medium: Print ISSN: 1999-4923 (Print) Linking ISSN: 19994923 NLM ISO Abbreviation: Pharmaceutics Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI
مستخلص: Introduction: Neutron-activated samarium-153-oxide-loaded polystyrene ([ 153 Sm]Sm 2 O 3 -PS) microspheres has been developed in previous study as a potential theranostic agent for hepatic radioembolization. In this study, the therapeutic efficacy and diagnostic imaging capabilities of the formulation was assessed using liver cancer Sprague-Dawley (SD) rat model. Methods: Twelve male SD rats (150-200 g) that implanted with N1-S1 hepatoma cell line orthotopically were divided into two groups (study versus control) to monitor the tumour growth along 60 days of treatment. The study group received an intra-tumoural injection of approximately 37 MBq of [ 153 Sm]Sm 2 O 3 -PS microspheres, while control group received an intra-tumoural injection of 0.1 mL of saline solution. A clinical single photon emission computed tomography/computed tomography (SPECT/CT) system was used to scan the rats at Day 5 post-injection to investigate the diagnostic imaging capabilities of the microspheres. All rats were monitored for change in tumour volume using a portable ultrasound system throughout the study period. Histopathological examination (HPE) was performed after the rats were euthanized at Day 60. Results: At Day 60, no tumour was observed on the ultrasound images of all rats in the study group. In contrast, the tumour volumes in the control group were 24-fold larger compared to baseline. Statistically significant difference was observed in tumour volumes between the study and control groups ( p < 0.05). The SPECT/CT images clearly displayed the location of [ 153 Sm]Sm 2 O 3 -PS in the liver tumour of all rats at Day 5 post-injection. Additionally, the [ 153 Sm]Sm 2 O 3 -PS microspheres was visible on the CT images and this has added to the benefits of 153 Sm as a CT contrast agent. The HPE results showed that the [ 153 Sm]Sm 2 O 3 -PS microspheres remained concentrated at the injection site with no tumour cells observed in the study group. Conclusions: Neutron-activated [ 153 Sm]Sm 2 O 3 -PS microspheres demonstrated excellent therapeutic and diagnostic imaging capabilities for theranostic treatment of liver cancer in a SD rat model. Further studies with different animal and tumour models are planned to validate this finding.
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معلومات مُعتمدة: FRGS/1/2019/SKK06/ TAYLOR/02/3 Ministry of Higher Education, Malaysia
فهرسة مساهمة: Keywords: Sprague-Dawley rat; liver tumour; microspheres; polystyrene; samarium-153; theranostics
تواريخ الأحداث: Date Created: 20230225 Latest Revision: 20230228
رمز التحديث: 20230228
مُعرف محوري في PubMed: PMC9958749
DOI: 10.3390/pharmaceutics15020536
PMID: 36839858
قاعدة البيانات: MEDLINE
الوصف
تدمد:1999-4923
DOI:10.3390/pharmaceutics15020536