دورية أكاديمية
أعرض في EDS

The association of cell adhesion molecules and selectins (VCAM-1, ICAM-1, E-selectin, L-selectin, and P-selectin) with microvascular complications in patients with type 2 diabetes: A follow-up study.

التفاصيل البيبلوغرافية
العنوان: The association of cell adhesion molecules and selectins (VCAM-1, ICAM-1, E-selectin, L-selectin, and P-selectin) with microvascular complications in patients with type 2 diabetes: A follow-up study.
المؤلفون: Siddiqui K; Strategic Center for Diabetes Research, College of Medicine, King Saud University, Riyadh, Saudi Arabia., George TP; Strategic Center for Diabetes Research, College of Medicine, King Saud University, Riyadh, Saudi Arabia., Mujammami M; Strategic Center for Diabetes Research, College of Medicine, King Saud University, Riyadh, Saudi Arabia.; University Diabetes Center, King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia.; Department of Medicine, College of Medicine, and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia., Isnani A; Obesity Research Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia., Alfadda AA; Strategic Center for Diabetes Research, College of Medicine, King Saud University, Riyadh, Saudi Arabia.; Department of Medicine, College of Medicine, and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia.; Obesity Research Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
المصدر: Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2023 Feb 09; Vol. 14, pp. 1072288. Date of Electronic Publication: 2023 Feb 09 (Print Publication: 2023).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101555782 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2392 (Print) Linking ISSN: 16642392 NLM ISO Abbreviation: Front Endocrinol (Lausanne) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Lausanne : Frontiers Research Foundation]
مواضيع طبية MeSH: Diabetes Mellitus, Type 2*/complications , Diabetic Neuropathies* , Diabetic Nephropathies*/etiology , Diabetic Retinopathy*/epidemiology , Diabetic Retinopathy*/etiology, Humans ; Adult ; Middle Aged ; Aged ; Vascular Cell Adhesion Molecule-1 ; L-Selectin ; Follow-Up Studies ; P-Selectin ; Intercellular Adhesion Molecule-1 ; Cell Adhesion Molecules ; Selectins
مستخلص: Objective: Chronic hyperglycemia induces pathogenic changes in the vascular endothelium and leads to the development of microvascular complications in patients with type 2 diabetes mellitus. Early identification of markers of diabetes complications may help to minimize the risk of the development and progression of microvascular complications.
Methods: This follow-up study was conducted in type 2 diabetic cohort aged between 30-70 years. Out of 160 eligible participants, 70 of them completed follow-up. Levels of cell adhesion molecules and selectins (VCAM-1, ICAM-1, E-selectin, L-selectin and P-selectin) at baseline and follow-up were measured using Randox Evidence biochip analyzer (UK). Development of microvascular complications (diabetic neuropathy, retinopathy and nephropathy) was evaluated.
Results: During the follow-up (2 years, median), 31 (44.3%) developed diabetic neuropathy, 10 (14.3%) developed diabetic retinopathy and, 27 (38.6%) developed diabetic nephropathy. A significant difference in levels of cell adhesion molecules and selectins were found in type 2 diabetic patients with and without microvascular complications. Multiple logistic regression analysis reveals that baseline level of VCAM-1 is significantly associated with microvascular complications; diabetic neuropathy(p=0.028), retinopathy (p=0.007) and nephropathy(p=<0.001). Additionally, levels of P-selectin (p=0.05) and L-selectin (p=0.008) is associated with diabetic nephropathy while retinopathy associated with L-selectin (p=0.005) only.
Conclusion: Cell adhesion molecules and selectins are indicators of microvascular complication among patients with type 2 diabetes (T2D). Association of these markers with the development of microvascular complications may provide additive information for developing strategies for diabetes management and prediction of microvascular complications.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2023 Siddiqui, George, Mujammami, Isnani and Alfadda.)
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فهرسة مساهمة: Keywords: adhesion molecule; complications; diabetic nephropathy; diabetic neuropathy; diabetic retinopathy
المشرفين على المادة: 0 (Vascular Cell Adhesion Molecule-1)
126880-86-2 (L-Selectin)
0 (P-Selectin)
126547-89-5 (Intercellular Adhesion Molecule-1)
0 (Cell Adhesion Molecules)
0 (Selectins)
تواريخ الأحداث: Date Created: 20230227 Date Completed: 20230228 Latest Revision: 20230228
رمز التحديث: 20240513
مُعرف محوري في PubMed: PMC9948618
DOI: 10.3389/fendo.2023.1072288
PMID: 36843591
قاعدة البيانات: MEDLINE
الوصف
تدمد:1664-2392
DOI:10.3389/fendo.2023.1072288