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Influence of Pore Size in Protein G'-Grafted Mesoporous Silica Nanoparticles as a Serum Pretreatment System for In Vitro Allergy Diagnosis.

التفاصيل البيبلوغرافية
العنوان: Influence of Pore Size in Protein G'-Grafted Mesoporous Silica Nanoparticles as a Serum Pretreatment System for In Vitro Allergy Diagnosis.
المؤلفون: Paris JL; Allergy Research Group, Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND. RICORS 'Enfermedades inflamatorias', Málaga, 29590, Spain., Monío C; Facultad de Ciencias, Universidad de Málaga, Málaga, 29010, Spain., Pérez-Moreno AM; Allergy Research Group, Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND. RICORS 'Enfermedades inflamatorias', Málaga, 29590, Spain., Jurado-Escobar R; Allergy Research Group, Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND. RICORS 'Enfermedades inflamatorias', Málaga, 29590, Spain., Bogas G; Allergy Research Group, Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND. RICORS 'Enfermedades inflamatorias', Málaga, 29590, Spain.; Allergy Unit, Hospital Regional Universitario de Málaga-HRUM, Málaga, 29009, Spain., Fernández TD; Allergy Research Group, Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND. RICORS 'Enfermedades inflamatorias', Málaga, 29590, Spain.; Departamento de Biología Celular Genética y Fisiología, Facultad de Ciencias, Universidad de Málaga, Málaga, 29010, Spain., Montañez MI; Allergy Research Group, Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND. RICORS 'Enfermedades inflamatorias', Málaga, 29590, Spain.; Departamento de Química Orgánica, Universidad de Málaga-UMA, Málaga, 29010, Spain., Mayorga C; Allergy Research Group, Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND. RICORS 'Enfermedades inflamatorias', Málaga, 29590, Spain.; Allergy Unit, Hospital Regional Universitario de Málaga-HRUM, Málaga, 29009, Spain., Torres MJ; Allergy Research Group, Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND. RICORS 'Enfermedades inflamatorias', Málaga, 29590, Spain.; Allergy Unit, Hospital Regional Universitario de Málaga-HRUM, Málaga, 29009, Spain.; Departmento de Medicina, Universidad de Málaga-UMA, Málaga, 29010, Spain.
المصدر: Advanced healthcare materials [Adv Healthc Mater] 2023 Jun; Vol. 12 (15), pp. e2203321. Date of Electronic Publication: 2023 Mar 08.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101581613 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2192-2659 (Electronic) Linking ISSN: 21922640 NLM ISO Abbreviation: Adv Healthc Mater Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Weinheim : Wiley-VCH, 2012-
مواضيع طبية MeSH: Hypersensitivity*/diagnosis , Nanoparticles*, Humans ; Silicon Dioxide ; Immunoglobulin G ; Immunoglobulin E
مستخلص: Particles with the capacity to bind to immunoglobulin G (IgG) can be used for the purification of IgG or to process clinical samples for diagnostic purposes. For in vitro allergy diagnosis, the high IgG levels in serum can interfere with the detection of allergen-specific IgE, the main diagnostic biomarker. Although commercially available, current materials present a low IgG capture capacity at large IgG concentrations or require complex protocols, preventing their use in the clinic. In this work, mesoporous silica nanoparticles are prepared with different pore sizes, to which IgG-binding protein G' is grafted. It is found that for one particular optimal pore size, the IgG capture capacity of the material is greatly enhanced. The capacity of this material to efficiently capture human IgG in a selective way (compared to IgE) is demonstrated in both solutions of known IgG concentrations as well as in complex samples, like serum, from healthy controls and allergic patients using a simple and fast incubation protocol. Interestingly, IgG removal using the best-performing material enhances in vitro IgE detection in sera from patients allergic to amoxicillin. These results highlight the great translation potential of this strategy to the clinic in the context of in vitro allergy diagnosis.
(© 2023 The Authors. Advanced Healthcare Materials published by Wiley-VCH GmbH.)
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فهرسة مساهمة: Keywords: allergies; immunoglobulin; in vitro diagnostics; mesoporous silica nanoparticles
المشرفين على المادة: 7631-86-9 (Silicon Dioxide)
0 (Immunoglobulin G)
37341-29-0 (Immunoglobulin E)
تواريخ الأحداث: Date Created: 20230227 Date Completed: 20230615 Latest Revision: 20230704
رمز التحديث: 20230704
DOI: 10.1002/adhm.202203321
PMID: 36847336
قاعدة البيانات: MEDLINE
الوصف
تدمد:2192-2659
DOI:10.1002/adhm.202203321