دورية أكاديمية
أعرض في EDS

Severe Diabetes Induction as a Generational Model for Growth Restriction of Rat.

التفاصيل البيبلوغرافية
العنوان: Severe Diabetes Induction as a Generational Model for Growth Restriction of Rat.
المؤلفون: da Cruz LL; Postgraduate Course on Tocogynecology, Laboratory of Experimental Research on Gynecology and Obstetrics, Botucatu Medical School, São Paulo State University (UNESP), Botucatu, São Paulo State, Brazil.; Institute of Biological and Health Sciences, Laboratory of System Physiology and Reproductive Toxicology, Federal University of Mato Grosso (UFMT), Barra do Garças, Mato Grosso State, Brazil., Barco VS; Postgraduate Course on Tocogynecology, Laboratory of Experimental Research on Gynecology and Obstetrics, Botucatu Medical School, São Paulo State University (UNESP), Botucatu, São Paulo State, Brazil., Paula VG; Postgraduate Course on Tocogynecology, Laboratory of Experimental Research on Gynecology and Obstetrics, Botucatu Medical School, São Paulo State University (UNESP), Botucatu, São Paulo State, Brazil.; Institute of Biological and Health Sciences, Laboratory of System Physiology and Reproductive Toxicology, Federal University of Mato Grosso (UFMT), Barra do Garças, Mato Grosso State, Brazil., Gallego FQ; Postgraduate Course on Tocogynecology, Laboratory of Experimental Research on Gynecology and Obstetrics, Botucatu Medical School, São Paulo State University (UNESP), Botucatu, São Paulo State, Brazil., Souza MR; Postgraduate Course on Tocogynecology, Laboratory of Experimental Research on Gynecology and Obstetrics, Botucatu Medical School, São Paulo State University (UNESP), Botucatu, São Paulo State, Brazil.; Institute of Biological and Health Sciences, Laboratory of System Physiology and Reproductive Toxicology, Federal University of Mato Grosso (UFMT), Barra do Garças, Mato Grosso State, Brazil., Corrente JE; Research Support Office, Botucatu Medical School, Sao Paulo State University (UNESP), Botucatu, São Paulo State, Brazil., Zambrano E; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Department of Reproductive Biology, Mexico City, Mexico., Volpato GT; Institute of Biological and Health Sciences, Laboratory of System Physiology and Reproductive Toxicology, Federal University of Mato Grosso (UFMT), Barra do Garças, Mato Grosso State, Brazil., Damasceno DC; Postgraduate Course on Tocogynecology, Laboratory of Experimental Research on Gynecology and Obstetrics, Botucatu Medical School, São Paulo State University (UNESP), Botucatu, São Paulo State, Brazil. debora.damasceno@unesp.br.
المصدر: Reproductive sciences (Thousand Oaks, Calif.) [Reprod Sci] 2023 Aug; Vol. 30 (8), pp. 2416-2428. Date of Electronic Publication: 2023 Feb 27.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 101291249 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1933-7205 (Electronic) Linking ISSN: 19337191 NLM ISO Abbreviation: Reprod Sci Subsets: MEDLINE
أسماء مطبوعة: Publication: 2020- : [New York] : Springer
Original Publication: Thousand Oaks, Calif. : Sage
مواضيع طبية MeSH: Insulin Resistance* , Diabetes, Gestational*/metabolism, Humans ; Rats ; Pregnancy ; Animals ; Female ; Placenta/metabolism ; Rats, Wistar ; Fetal Growth Retardation/etiology ; Fetal Growth Retardation/metabolism ; Rats, Sprague-Dawley ; Blood Glucose/metabolism
مستخلص: We used uncontrolled maternal diabetes as a model to provoke fetal growth restriction in the female in the first generation (F 1 ) and to evaluate reproductive outcomes and the possible changes in metabolic systems during pregnancy, as well as the repercussions at birth in the second generation (F 2 ). For this, nondiabetic and streptozotocin-induced severely diabetic Sprague-Dawley rats were mated to obtain female pups (F 1 ), which were classified as adequate (AGA) or small (SGA) for gestational weight. Afterward, we composed two groups: F 1 AGA from nondiabetic dams (Control) and F 1 SGA from severely diabetic dams (Restricted) (n minimum = 10 animals/groups). At adulthood, these rats were submitted to the oral glucose tolerance test, mated, and at day 17 of pregnancy, blood samples were collected to determine glucose and insulin levels for assessment of insulin resistance. At the end of the pregnancy, the blood and liver samples were collected to evaluate redox status markers, and reproductive, fetal, and placental outcomes were analyzed. Maternal diabetes was responsible for increased SGA rates and a lower percentage of AGA fetuses (F 1 generation). The restricted female pups from severely diabetic dams presented rapid neonatal catch-up growth, glucose intolerance, and insulin resistance status before and during pregnancy. At term pregnancy of F 1 generation, oxidative stress status was observed in the maternal liver and blood samples. In addition, their offspring (F 2 generation) had lower fetal weight and placental efficiency, regardless of gender, which caused fetal growth restriction and confirmed the fetal programming influence.
(© 2023. The Author(s), under exclusive licence to Society for Reproductive Investigation.)
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فهرسة مساهمة: Keywords: Animal models; Fetal programming; Hyperglycemia; Low birth weight; Malondialdehyde; Pregnancy
المشرفين على المادة: 0 (Blood Glucose)
تواريخ الأحداث: Date Created: 20230228 Date Completed: 20230721 Latest Revision: 20230722
رمز التحديث: 20230722
DOI: 10.1007/s43032-023-01198-9
PMID: 36849856
قاعدة البيانات: MEDLINE
الوصف
تدمد:1933-7205
DOI:10.1007/s43032-023-01198-9