دورية أكاديمية
أعرض في EDS

Incipient Parallel Evolution of SARS-CoV-2 Deltacron Variant in South Brazil.

التفاصيل البيبلوغرافية
العنوان: Incipient Parallel Evolution of SARS-CoV-2 Deltacron Variant in South Brazil.
المؤلفون: Sant'Anna FH; Hospital Moinhos de Vento, Porto Alegre 90035-000, RS, Brazil., Finger Andreis T; Hospital Moinhos de Vento, Porto Alegre 90035-000, RS, Brazil., Salvato RS; Centro de Desenvolvimento Científico e Tecnológico, Centro Estadual de Vigilância em Saúde, Secretaria Estadual da Saúde do Rio Grande do Sul (CDCT/CEVS/SES-RS), Porto Alegre 90450-190, RS, Brazil., Muterle Varela AP; Hospital Moinhos de Vento, Porto Alegre 90035-000, RS, Brazil., Comerlato J; Hospital Moinhos de Vento, Porto Alegre 90035-000, RS, Brazil., Gregianini TS; Laboratório Central de Saúde Pública, Centro Estadual de Vigilância em Saúde, Secretaria Estadual da Saúde do Rio Grande do Sul (LACEN/CEVS/SES-RS), Porto Alegre 90450-190, RS, Brazil., Barcellos RB; Centro de Desenvolvimento Científico e Tecnológico, Centro Estadual de Vigilância em Saúde, Secretaria Estadual da Saúde do Rio Grande do Sul (CDCT/CEVS/SES-RS), Porto Alegre 90450-190, RS, Brazil., de Souza Godinho FM; Centro de Desenvolvimento Científico e Tecnológico, Centro Estadual de Vigilância em Saúde, Secretaria Estadual da Saúde do Rio Grande do Sul (CDCT/CEVS/SES-RS), Porto Alegre 90450-190, RS, Brazil., Resende PC; Laboratory of Respiratory Viruses and Measles, Oswaldo Cruz Institute (IOC), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21040-900, RJ, Brazil., da Luz Wallau G; Departamento de Entomologia e Núcleo de Bioinformática, Instituto Aggeu Magalhães, Fundação Oswaldo Cruz Pernambuco (FIOCRUZ-PE), Recife 50740-465, PE, Brazil., Y Castro TR; Departamento de Análises Clínicas, Universidade Federal de Santa Maria, Santa Maria 97105-900, RS, Brazil., Casarin BC; Departamento de Análises Clínicas, Universidade Federal de Santa Maria, Santa Maria 97105-900, RS, Brazil., de Almeida Vieira A; Departamento de Análises Clínicas, Universidade Federal de Santa Maria, Santa Maria 97105-900, RS, Brazil., Schwarzbold AV; Departamento de Análises Clínicas, Universidade Federal de Santa Maria, Santa Maria 97105-900, RS, Brazil., de Arruda Trindade P; Departamento de Análises Clínicas, Universidade Federal de Santa Maria, Santa Maria 97105-900, RS, Brazil., Tumioto Giannini GL; Hospital Moinhos de Vento, Porto Alegre 90035-000, RS, Brazil., Freese L; Hospital Moinhos de Vento, Porto Alegre 90035-000, RS, Brazil., Bristot G; Hospital Moinhos de Vento, Porto Alegre 90035-000, RS, Brazil., Brasil CS; Hospital Moinhos de Vento, Porto Alegre 90035-000, RS, Brazil., de Oliveira Rocha B; Hospital Moinhos de Vento, Porto Alegre 90035-000, RS, Brazil., Martins PB; Hospital Moinhos de Vento, Porto Alegre 90035-000, RS, Brazil., de Oliveira FH; Hospital Moinhos de Vento, Porto Alegre 90035-000, RS, Brazil., van Oosterhout C; School of Environmental Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK., Wendland E; Hospital Moinhos de Vento, Porto Alegre 90035-000, RS, Brazil.; Graduate Program in Biosciences, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre 90050-170, RS, Brazil.
المصدر: Vaccines [Vaccines (Basel)] 2023 Jan 18; Vol. 11 (2). Date of Electronic Publication: 2023 Jan 18.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101629355 Publication Model: Electronic Cited Medium: Print ISSN: 2076-393X (Print) Linking ISSN: 2076393X NLM ISO Abbreviation: Vaccines (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG
مستخلص: With the coexistence of multiple lineages and increased international travel, recombination and gene flow are likely to become increasingly important in the adaptive evolution of SARS-CoV-2. These processes could result in genetic introgression and the incipient parallel evolution of multiple recombinant lineages. However, identifying recombinant lineages is challenging, and the true extent of recombinant evolution in SARS-CoV-2 may be underestimated. This study describes the first SARS-CoV-2 Deltacron recombinant case identified in Brazil. We demonstrate that the recombination breakpoint is at the beginning of the Spike gene. The 5' genome portion (circa 22 kb) resembles the AY.101 (Delta), and the 3' genome portion (circa 8 kb nucleotides) is most similar to the BA.1.1 (Omicron). Furthermore, evolutionary genomic analyses indicate that the new strain emerged after a single recombination event between lineages of diverse geographical locations in December 2021 in South Brazil. This Deltacron, AYBA-RS, is one of the dozens of recombinants described in 2022. The submission of only four sequences in the GISAID database suggests that this lineage had a minor epidemiological impact. However, the recent emergence of this and other Deltacron recombinant lineages (XD, XF, and XS) suggests that gene flow and recombination may play an increasingly important role in the COVID-19 pandemic. We explain the evolutionary and population genetic theory that supports this assertion, concluding that this stresses the need for continued genomic surveillance. This monitoring is vital for countries where multiple variants are present, as well as for countries that receive significant inbound international travel.
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فهرسة مساهمة: Keywords: AYBA-RS; Brazil; COVID-19; Deltacron; SARS-CoV-2 genomes; adaptive landscape; gene flow; genetic introgression; recombinant; recombination; severe acute respiratory syndrome coronavirus 2
تواريخ الأحداث: Date Created: 20230228 Latest Revision: 20230301
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9961971
DOI: 10.3390/vaccines11020212
PMID: 36851091
قاعدة البيانات: MEDLINE
الوصف
تدمد:2076-393X
DOI:10.3390/vaccines11020212