دورية أكاديمية
أعرض في EDS

Impact of BNT162b2 Booster Dose on SARS-CoV-2 Anti-Trimeric Spike Antibody Dynamics in a Large Cohort of Italian Health Care Workers.

التفاصيل البيبلوغرافية
العنوان: Impact of BNT162b2 Booster Dose on SARS-CoV-2 Anti-Trimeric Spike Antibody Dynamics in a Large Cohort of Italian Health Care Workers.
المؤلفون: Renna LV; Biobank BioCor, IRCCS Policlinico San Donato, San Donato Milanese, 20097 Milan, Italy., Bertani F; Residency Program in Clinical Pathology and Clinical Biochemistry, University of Milano, 20157 Milan, Italy., Podio A; Residency Program in Clinical Pathology and Clinical Biochemistry, University of Milano, 20157 Milan, Italy., Boveri S; Laboratory of Biostatistics and Data Management, Scientific Directorate, IRCCS Policlinico San Donato, San Donato Milanese, 20097 Milan, Italy., Carrara M; Residency Program in Clinical Pathology and Clinical Biochemistry, University of Milano, 20157 Milan, Italy., Pinton A; Biobank BioCor, IRCCS Policlinico San Donato, San Donato Milanese, 20097 Milan, Italy., Milani V; Laboratory of Biostatistics and Data Management, Scientific Directorate, IRCCS Policlinico San Donato, San Donato Milanese, 20097 Milan, Italy., Spuria G; Residency Program in Clinical Pathology and Clinical Biochemistry, University of Milano, 20157 Milan, Italy., Nizza AF; Residency Program in Clinical Pathology and Clinical Biochemistry, University of Milano, 20157 Milan, Italy., Basilico S; Endocrinology Unit, Clinical Nutrition and Cardiovascular Prevention Service, IRCCS Policlinico San Donato, San Donato Milanese, 20097 Milan, Italy., Dubini C; Endocrinology Unit, Clinical Nutrition and Cardiovascular Prevention Service, IRCCS Policlinico San Donato, San Donato Milanese, 20097 Milan, Italy., Cerri A; Scientific Directorate, IRCCS Policlinico San Donato, San Donato Milanese, 20097 Milan, Italy., Menicanti L; Scientific Directorate, IRCCS Policlinico San Donato, San Donato Milanese, 20097 Milan, Italy.; Department of Cardiac Surgery, IRCCS Policlinico San Donato, San Donato Milanese, 20097 Milan, Italy., Corsi-Romanelli MM; Biobank BioCor, IRCCS Policlinico San Donato, San Donato Milanese, 20097 Milan, Italy.; Department of Biomedical Sciences for Health, University of Milano, 20133 Milan, Italy.; Operative Unit of Laboratory Medicine-Clinical Pathology, Department of Pathology and Laboratory Medicine, IRCCS Policlinico San Donato, San Donato Milanese, 20097 Milan, Italy., Malavazos AE; Endocrinology Unit, Clinical Nutrition and Cardiovascular Prevention Service, IRCCS Policlinico San Donato, San Donato Milanese, 20097 Milan, Italy.; Department of Biomedical, Surgical and Dental Sciences, University of Milano, 20122 Milan, Italy., Cardani R; Biobank BioCor, IRCCS Policlinico San Donato, San Donato Milanese, 20097 Milan, Italy.
المصدر: Vaccines [Vaccines (Basel)] 2023 Feb 17; Vol. 11 (2). Date of Electronic Publication: 2023 Feb 17.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101629355 Publication Model: Electronic Cited Medium: Print ISSN: 2076-393X (Print) Linking ISSN: 2076393X NLM ISO Abbreviation: Vaccines (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG
مستخلص: Accurate studies on the dynamics of Pfizer-Biontech BNT162b2-induced antibodies are crucial to better tailor booster dose administration depending on age, comorbidities, and previous natural infection with SARS-CoV-2. To date, little is known about the durability and kinetics of antibody titers months after receiving a booster dose. In this work, we studied the dynamic of anti-Trimeric Spike (anti-TrimericS) IgG titer in the healthcare worker population of a large academic hospital in Northern Italy, in those who had received two vaccine doses plus a booster dose. Blood samples were collected on the day of dose 1, dose 2, then 1 month, 3 months, and 6 months after dose 2, the day of the administration of the booster dose, then 1 month and 3 months after the booster dose. The vaccination immunogenicity was evaluated by dosing anti-TrimericS IgG titer, which was further studied in relation to SARS-CoV-2 infection status, age, and sex. Our results suggest that after the booster dose, the anti-TrimericS IgG production was higher in the subjects that were infected only after the completion of the vaccination cycle, compared to those that were infected both before and after the vaccination campaign. Moreover, the booster dose administration exerts a leveling effect, mitigating the differences in the immunogenicity dependent on sex and age.
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معلومات مُعتمدة: Ricerca Corrente funding to IRCCS Policlinico San Donato Italian Ministry of Healthv; BioCor Biobank Project GSD Foundation
فهرسة مساهمة: Keywords: BNT162b2; COVID-19; SARS-CoV-2; anti-Trimeric Spike; antibody; booster dose; immunity; natural infection; vaccine
تواريخ الأحداث: Date Created: 20230228 Latest Revision: 20230301
رمز التحديث: 20230301
مُعرف محوري في PubMed: PMC9959637
DOI: 10.3390/vaccines11020463
PMID: 36851340
قاعدة البيانات: MEDLINE
الوصف
تدمد:2076-393X
DOI:10.3390/vaccines11020463