دورية أكاديمية
[Effect of Shugan Tiaoshen acupuncture combined with western medication on depression-insomnia comorbidity due to COVID-19 quarantine: a multi-central randomized controlled trial].
| العنوان: | [Effect of Shugan Tiaoshen acupuncture combined with western medication on depression-insomnia comorbidity due to COVID-19 quarantine: a multi-central randomized controlled trial]. |
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| المؤلفون: | Yan LD; Second Clinical Medicine College, Guangzhou University of CM, Guangzhou 510405, Guangdong Province, China; Department of Acupuncture and Moxibustion, Shenzhen Bao'an TCM Hospital, Shenzhen 518100, Guangdong Province; Shenzhen Bao'an Research Center for Acupuncture and Moxibustion, Shenzhen 518100, Guangdong Province; Shenzhen Government 'Medical Health Project', Professor FU Wen-bin's Team of Guangdong Provincial Hospital of TCM, Shenzhen 518100., Li ZX; Department of Acupuncture and Moxibustion, Shenzhen Bao'an TCM Hospital, Shenzhen 518100, Guangdong Province; Shenzhen Bao'an Research Center for Acupuncture and Moxibustion, Shenzhen 518100, Guangdong Province., Zhang Y; Department of Acupuncture and Moxibustion, Shenzhen Bao'an TCM Hospital, Shenzhen 518100, Guangdong Province; Shenzhen Bao'an Research Center for Acupuncture and Moxibustion, Shenzhen 518100, Guangdong Province; Shenzhen Government 'Medical Health Project', Professor FU Wen-bin's Team of Guangdong Provincial Hospital of TCM, Shenzhen 518100., Liang XS; Shenzhen Government 'Medical Health Project', Professor FU Wen-bin's Team of Guangdong Provincial Hospital of TCM, Shenzhen 518100; Guangdong Provincial Hospital of TCM, Guangzhou 510120., Li JJ; Department of Acupuncture and Moxibustion, Shenzhen Bao'an TCM Hospital, Shenzhen 518100, Guangdong Province; Shenzhen Bao'an Research Center for Acupuncture and Moxibustion, Shenzhen 518100, Guangdong Province; Shenzhen Government 'Medical Health Project', Professor FU Wen-bin's Team of Guangdong Provincial Hospital of TCM, Shenzhen 518100., Wu M; Department of Acupuncture and Moxibustion, Shenzhen Bao'an TCM Hospital, Shenzhen 518100, Guangdong Province; Shenzhen Bao'an Research Center for Acupuncture and Moxibustion, Shenzhen 518100, Guangdong Province., Shi GA; Department of Acupuncture and Moxibustion, Shenzhen Bao'an TCM Hospital, Shenzhen 518100, Guangdong Province; Shenzhen Bao'an Research Center for Acupuncture and Moxibustion, Shenzhen 518100, Guangdong Province., Chen RM; Department of Acupuncture and Moxibustion, Shenzhen Bao'an TCM Hospital, Shenzhen 518100, Guangdong Province; Shenzhen Bao'an Research Center for Acupuncture and Moxibustion, Shenzhen 518100, Guangdong Province., Ji X; Department of Acupuncture and Moxibustion, Shenzhen Bao'an TCM Hospital, Shenzhen 518100, Guangdong Province; Shenzhen Bao'an Research Center for Acupuncture and Moxibustion, Shenzhen 518100, Guangdong Province., Zuo SY; Department of Acupuncture and Moxibustion, Shenzhen Bao'an TCM Hospital, Shenzhen 518100, Guangdong Province., Chen SY; Department of Acupuncture and Moxibustion, Shenzhen Bao'an TCM Hospital, Shenzhen 518100, Guangdong Province; Shenzhen Bao'an Research Center for Acupuncture and Moxibustion, Shenzhen 518100, Guangdong Province; Shenzhen Government 'Medical Health Project', Professor FU Wen-bin's Team of Guangdong Provincial Hospital of TCM, Shenzhen 518100., Zhou P; Department of Acupuncture and Moxibustion, Shenzhen Bao'an TCM Hospital, Shenzhen 518100, Guangdong Province; Shenzhen Bao'an Research Center for Acupuncture and Moxibustion, Shenzhen 518100, Guangdong Province; Shenzhen Government 'Medical Health Project', Professor FU Wen-bin's Team of Guangdong Provincial Hospital of TCM, Shenzhen 518100., Fu WB; Second Clinical Medicine College, Guangzhou University of CM, Guangzhou 510405, Guangdong Province, China; Shenzhen Government 'Medical Health Project', Professor FU Wen-bin's Team of Guangdong Provincial Hospital of TCM, Shenzhen 518100; Guangdong Provincial Hospital of TCM, Guangzhou 510120. |
| المصدر: | Zhongguo zhen jiu = Chinese acupuncture & moxibustion [Zhongguo Zhen Jiu] 2023 Mar 12; Vol. 43 (3), pp. 255-60. |
| نوع المنشور: | Randomized Controlled Trial; English Abstract; Journal Article |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Guoji Shudian Country of Publication: China NLM ID: 8600658 Publication Model: Print Cited Medium: Print ISSN: 0255-2930 (Print) Linking ISSN: 02552930 NLM ISO Abbreviation: Zhongguo Zhen Jiu Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Pei-Ching : Guoji Shudian Original Publication: Beijing : Zhonghua quan guo Zhong yi zhen jiu xue hui : Zhong yi yan jiu yuan zhen jiu yan jiu suo, 1981- |
| مواضيع طبية MeSH: | Sleep Initiation and Maintenance Disorders* , COVID-19* , Acupuncture Therapy*, Humans ; Depression ; Quarantine ; Serotonin ; Comorbidity |
| مستخلص: | Objective: To observe the effect of Shugan Tiaoshen acupuncture (acupuncture for soothing the liver and regulating the mentality) combined with western medication on depression and sleep quality in the patients with depression-insomnia comorbidity due to COVID-19 quarantine, and investigate the potential mechanism from the perspective of cortical excitability. Methods: Sixty patients with depression-insomnia comorbidity due to COVID-19 quarantine were randomly divided into an acupuncture group and a sham-acupuncture group, 30 cases in each one. The patients of both groups were treated with oral administration of sertraline hydrochloride tablets. In the acupuncture group, Shugan Tiaoshen acupuncture was supplemented. Body acupuncture was applied to Yintang (GV 24 + ), Baihui (GV 20), Hegu (LI 4), Zhaohai (KI 6), Qihai (CV 6), etc. The intradermal needling was used at Xin (CO Results: After treatment and in follow-up, SDS and ISI scores were decreased in both groups compared with those before treatment ( P <0.05), and the scores in the acupuncture group were lower than those in the sham-acupuncture group ( P <0.05), and the decrease range in the acupuncture group after treatment was larger than that in the sham-acupuncture group ( P <0.05). After treatment, rMT was reduced ( P <0.05), while MEP-A and CSP were increased ( P <0.05) in the acupuncture group compared with that before treatment. The levels of serum 5-HT in both groups were increased compared with those before treatment ( P <0.05). The rMT in the acupuncture group was lower than that in the sham-acupuncture group, while MEP-A and CSP, as well as the level of serum 5-HT were higher in the acupuncture group in comparison with the sham-acupuncture group ( P <0.05). Conclusion: Shugan Tiaoshen acupuncture combined with western medication can relieve depression and improve sleep quality in the patients with depression-insomnia comorbidity due to COVID-19 quarantine, which is probably related to rectifying the imbalanced excitatory and inhibitory neuronal functions. |
| فهرسة مساهمة: | Keywords: COVID-19; acupuncture; cortical excitability; depression-insomnia comorbidity; neuroplasticity; quarantine Local Abstract: [Publisher, Chinese] 目的： 观察疏肝调神法针刺联合西药对新型冠状病毒感染（简称“新冠”）疫情隔离经历所致抑郁失眠共病患者抑郁情绪及睡眠质量的影响，并从皮层兴奋性角度探讨其可能机制。 方法： 将60例新冠疫情隔离经历致抑郁失眠共病患者随机分为针刺组和假针刺组，各30例。两组均口服盐酸舍曲林片，针刺组采用疏肝调神法针刺（毫针取印堂、百会、合谷、照海、气海等，耳穴揿针取心、肝、肾）治疗，假针刺组采用假针刺（取穴同针刺组）治疗（随访结束后有补偿性治疗），两组均每2天治疗1次，每周3次，连续治疗8周。比较两组治疗前后及治疗结束后1个月（随访时）抑郁自评量表（SDS）评分及失眠严重程度指数（ISI）评分；检测两组治疗前后皮层兴奋性指标[静息运动阈值（rMT）、运动诱发电位振幅（MEP-A）、皮层静息期（CSP）]和血清5-羟色胺（5-HT）含量。 结果： 治疗后及随访时，两组患者SDS、ISI评分均较治疗前降低（ P <0.05），且针刺组低于假针刺组（ P <0.05），针刺组治疗后降低幅度大于假针刺组（ P <0.05）。治疗后，针刺组患者rMT较治疗前降低（ P <0.05），MEP-A、CSP较治疗前升高（ P <0.05），两组血清5-HT含量较治疗前升高（ P <0.05）；针刺组rMT低于假针刺组，MEP-A、CSP及血清5-HT含量高于假针刺组（ P <0.05）。 结论： 疏肝调神法针刺联合西药能够改善新冠疫情隔离经历致抑郁失眠共病患者的抑郁情绪和睡眠质量，可能与纠正失衡的兴奋性与抑制性神经元功能有关。. |
| المشرفين على المادة: | 333DO1RDJY (Serotonin) |
| تواريخ الأحداث: | Date Created: 20230301 Date Completed: 20230303 Latest Revision: 20230303 |
| رمز التحديث: | 20230303 |
| DOI: | 10.13703/j.0255-2930.20221030-k0004 |
| PMID: | 36858384 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0255-2930 |
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| DOI: | 10.13703/j.0255-2930.20221030-k0004 |