دورية أكاديمية
Erythropoietin promotes myocardial infarction repair in mice by improving the function of Sca-1 + stem cells.
| العنوان: | Erythropoietin promotes myocardial infarction repair in mice by improving the function of Sca-1 + stem cells. |
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| المؤلفون: | Zuo L; Key Laboratory of Cellular Physiology, Ministry of Education, and the Department of Physiology, School of Basic Sciences, Shanxi Medical University, Taiyuan 030001, China., Li DD; Key Laboratory of Cellular Physiology, Ministry of Education, and the Department of Physiology, School of Basic Sciences, Shanxi Medical University, Taiyuan 030001, China., Ma XX; Key Laboratory of Cellular Physiology, Ministry of Education, and the Department of Physiology, School of Basic Sciences, Shanxi Medical University, Taiyuan 030001, China., Shi SH; Key Laboratory of Cellular Physiology, Ministry of Education, and the Department of Physiology, School of Basic Sciences, Shanxi Medical University, Taiyuan 030001, China., Lyu DC; Department of Cardiology, the People's Hospital of Changzhi City, Changzhi 046000, China., Shen J; Key Laboratory of Cellular Physiology, Ministry of Education, and the Department of Physiology, School of Basic Sciences, Shanxi Medical University, Taiyuan 030001, China., Zhang WF; Center for Functional Experiments, Shanxi Medical University, Taiyuan 030001, China., Gao EH; Center for Translational Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA., Cao JM; Key Laboratory of Cellular Physiology, Ministry of Education, and the Department of Physiology, School of Basic Sciences, Shanxi Medical University, Taiyuan 030001, China. caojimin@126.com. |
| المصدر: | Sheng li xue bao : [Acta physiologica Sinica] [Sheng Li Xue Bao] 2023 Feb 25; Vol. 75 (1), pp. 36-48. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Science Press Country of Publication: China NLM ID: 20730130R Publication Model: Print Cited Medium: Internet ISSN: 0371-0874 (Print) Linking ISSN: 03710874 NLM ISO Abbreviation: Sheng Li Xue Bao Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Beijing : Science Press Original Publication: Beiping, 1953- |
| مواضيع طبية MeSH: | Erythropoietin* , Myocardial Infarction*, Animals ; Mice ; Ventricular Remodeling ; Heart ; Stem Cells |
| مستخلص: | Myocardial infarction (MI) is one of the leading causes of death in the world. With the improvement of clinical therapy, the mortality of acute MI has been significantly reduced. However, as for the long-term impact of MI on cardiac remodeling and cardiac function, there is no effective prevention and treatment measures. Erythropoietin (EPO), a glycoprotein cytokine essential to hematopoiesis, has anti-apoptotic and pro-angiogenetic effects. Studies have shown that EPO plays a protective role in cardiomyocytes in cardiovascular diseases, such as cardiac ischemia injury and heart failure. EPO has been demonstrated to protect ischemic myocardium and improve MI repair by promoting the activation of cardiac progenitor cells (CPCs). This study aimed to investigate whether EPO can promote MI repair by enhancing the activity of stem cell antigen 1 positive stem cells (Sca-1 + SCs). Darbepoetin alpha (a long-acting EPO analog, EPO |
| المشرفين على المادة: | 11096-26-7 (Erythropoietin) |
| تواريخ الأحداث: | Date Created: 20230302 Date Completed: 20230303 Latest Revision: 20230303 |
| رمز التحديث: | 20231215 |
| PMID: | 36859833 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0371-0874 |
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