دورية أكاديمية
The Differential Effects of Chronic Alcohol and Cigarette Smoke Exposures on Cognitive-Behavioral Dysfunction in Long Evans Rats.
| العنوان: | The Differential Effects of Chronic Alcohol and Cigarette Smoke Exposures on Cognitive-Behavioral Dysfunction in Long Evans Rats. |
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| المؤلفون: | Yalcin EB; Division of Research, Providence VA Medical Center, Providence, RI, USA.; Liver Research Center, Division of Gastroenterology and Department of Medicine, Rhode Island Hospital and the Alpert Medical School of Brown University, Providence, RI, USA., Delikkaya BN; Division of Research, Providence VA Medical Center, Providence, RI, USA.; Liver Research Center, Division of Gastroenterology and Department of Medicine, Rhode Island Hospital and the Alpert Medical School of Brown University, Providence, RI, USA., Pelit W; Chemical Biology and English, Brown University, Providence, RI, USA., Tong M; Liver Research Center, Division of Gastroenterology and Department of Medicine, Rhode Island Hospital and the Alpert Medical School of Brown University, Providence, RI, USA., De La Monte SM; Liver Research Center, Division of Gastroenterology and Department of Medicine, Rhode Island Hospital and the Alpert Medical School of Brown University, Providence, RI, USA.; Departments of Medicine, Neurology, and Pathology and Laboratory Medicine, Rhode Island Hospital, Women & Infants Hospital of Rhode Island, Alpert Medical School of Brown University, Providence VA Medical Center, Providence, RI, USA., Rounds S; Division of Research, Providence VA Medical Center, Providence, RI, USA.; Departments of Medicine and Pathology and Laboratory Medicine, Warren Alpert Medical School of Brown University, Vascular Research Laboratory, Providence VA Medical Center, Providence, RI, USA. |
| المصدر: | Journal of behavioral and brain science [J Behav Brain Sci] 2022 Sep; Vol. 12 (9), pp. 413-432. Date of Electronic Publication: 2022 Sep 20. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Scientific Research Pub Country of Publication: United States NLM ID: 101600257 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2160-5866 (Print) Linking ISSN: 21605866 NLM ISO Abbreviation: J Behav Brain Sci Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [Irvine, Calif.] : Scientific Research Pub. |
| مستخلص: | Background and Objective: Chronic heavy alcohol consumption and daily cigarette smoking are the most prevalent substance use problems in the U.S., including Veterans. Excessive alcohol use causes neurocognitive and behavioral deficits that can be linked to neurodegeneration. Similarly, preclinical and clinical data suggest that smoking also leads to brain atrophy. This study examines the differential and additive effects of alcohol and cigarette smoke (CS) exposures on cognitive-behavioral function. Methods: A 4-way experimental model of chronic alcohol and CS exposures was generated using 4-week-old male and female Long Evans rats that were pair-fed with Lieber-deCarli isocaloric liquid diets containing 0% or 24% ethanol for 9 weeks. Half of the rats in the control and ethanol groups were exposed to CS for 4 hours/day and 4 days/week for 9 weeks. All rats were subjected to Morris Water Maze, Open Field, and Novel Object Recognition testing in the last experimental week. Results: Chronic alcohol exposure impaired spatial learning as shown by significantly increased latency to locate the platform, and it caused anxiety-like behavior marked by the significantly reduced percentage of entries to the center of the arena. Chronic CS exposure impaired recognition memory as suggested by significantly less time spent at the novel object. Combined exposures to alcohol and CS did not show any significant additive or interactive effect on cognitive-behavioral function. Conclusion: Chronic alcohol exposure was the main driver of spatial learning, while the effect of secondhand CS exposure was not robust. Future studies need to mimic direct CS exposure effects in humans. Competing Interests: Conflicts of Interest The authors declared no conflicts of interest with respect to the research, authorship, and/or publication of this article. |
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| معلومات مُعتمدة: | R37 AA011431 United States AA NIAAA NIH HHS; R01 AA028408 United States AA NIAAA NIH HHS; R01 HL130230 United States HL NHLBI NIH HHS; R01 AA012908 United States AA NIAAA NIH HHS; R01 AA011431 United States AA NIAAA NIH HHS; IK2 BX004961 United States BX BLRD VA |
| فهرسة مساهمة: | Keywords: Alcohol; Anxiety; Cigarette Smoke; Rat; Recognition Memory; Spatial Learning; White Matter |
| تواريخ الأحداث: | Date Created: 20230302 Latest Revision: 20240607 |
| رمز التحديث: | 20240607 |
| مُعرف محوري في PubMed: | PMC9974143 |
| DOI: | 10.4236/jbbs.2022.129024 |
| PMID: | 36860550 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2160-5866 |
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| DOI: | 10.4236/jbbs.2022.129024 |