دورية أكاديمية
أعرض في EDS

High-Intensity Interval Training Minimizes the Deleterious Effects of Arterial Hypertension on the Urinary Bladder of Spontaneously Hypertensive Rats.

التفاصيل البيبلوغرافية
العنوان: High-Intensity Interval Training Minimizes the Deleterious Effects of Arterial Hypertension on the Urinary Bladder of Spontaneously Hypertensive Rats.
المؤلفون: Batista VRG; Department of Physical Education, São Paulo State University (UNESP), School of Technology and Sciences, Presidente Prudente, São Paulo, Brazil., Correia RR; Multicenter Graduate Program in Physiological Sciences, SBFis, São Paulo State University (UNESP), Presidente Prudente, SP, Brazil., Fernandes VS; Departamento de Fisiología, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain., Veras ASC; Multicenter Graduate Program in Physiological Sciences, SBFis, São Paulo State University (UNESP), Presidente Prudente, SP, Brazil., Tavares MEA; Multicenter Graduate Program in Physiological Sciences, SBFis, São Paulo State University (UNESP), Presidente Prudente, SP, Brazil., Chaves-Neto AH; Multicenter Graduate Program in Physiological Sciences, SBFis, São Paulo State University (UNESP), Presidente Prudente, SP, Brazil.; Department of Basic Sciences, School of Dentistry, São Paulo State University (UNESP), Araçatuba São Paulo, Brazil., Fiais GA; Multicenter Graduate Program in Physiological Sciences, SBFis, São Paulo State University (UNESP), Presidente Prudente, SP, Brazil., de Souza FLA; Department of Physical Education, São Paulo State University (UNESP), School of Technology and Sciences, Presidente Prudente, São Paulo, Brazil., Pacagnelli FL; Postgraduate Animal Science Program, University of Western São Paulo (UNOESTE), Presidente Prudente, Brazil., Suggett CB; Department of Biomedical Sciences, University of Guelph, Guelph, ON, Canada., Teixeira GR; Department of Physical Education, São Paulo State University (UNESP), School of Technology and Sciences, Presidente Prudente, São Paulo, Brazil.; Multicenter Graduate Program in Physiological Sciences, SBFis, São Paulo State University (UNESP), Presidente Prudente, SP, Brazil.
المصدر: Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2023 Feb 21; Vol. 2023, pp. 9979397. Date of Electronic Publication: 2023 Feb 21 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Hindawi Pub. Corp Country of Publication: United States NLM ID: 101479826 Publication Model: eCollection Cited Medium: Internet ISSN: 1942-0994 (Electronic) Linking ISSN: 19420994 NLM ISO Abbreviation: Oxid Med Cell Longev Subsets: MEDLINE
أسماء مطبوعة: Publication: 2011- : New York : Hindawi Pub. Corp.
Original Publication: 2008-2010: Austin, TX : Landes Bioscience
مواضيع طبية MeSH: High-Intensity Interval Training* , Hypertension*/complications , Hypertension*/therapy , Urinary Bladder* , Physical Conditioning, Animal*, Animals ; Rats ; bcl-2-Associated X Protein ; Rats, Inbred SHR
مستخلص: Arterial hypertension promotes urological complications by modifying the functional capacity of the urinary bladder. On the other hand, physical exercise has been suggested as a nonpharmacological tool to improve blood pressure regulation. High-intensity interval training (HIIT) can effectively increase peak oxygen consumption, body composition, physical fitness, and health-related characteristics of adults; however, its action on the urinary bladder is little discussed. In the present study, we verified the effect of HIIT on the modulation of the redox state, morphology, and inflammatory and apoptotic processes of the urinary bladder of hypertensive rats. Spontaneously hypertensive rats (SHR) were divided into two groups: SHR sedentary and SHR submitted to HIIT. Arterial hypertension promoted an increase in the plasma redox state, modified the volume of the urinary bladder, and increased collagen deposition in detrusor muscle. It was also possible to identify, in the sedentary SHR group, an increase in inflammatory markers such as IL-6 and TNF- α in the urinary bladder, as well as a reduction in BAX expression. However, in the HIIT group, reduced blood pressure levels were observed, together with an improvement in morphology, such as a decrease in collagen deposition. HIIT also regulated the proinflammatory response, promoting increases in IL-10 and BAX expressions and in the number of plasma antioxidant enzymes. The present work highlights the intracellular pathways involved with the oxidative and inflammatory capacity of the urinary bladder and the potential effect of HIIT on the regulation of the urothelium and detrusor muscle of hypertensive rats.
Competing Interests: The authors declare that they have no conflicts of interest.
(Copyright © 2023 Victor Rogério Garcia Batista et al.)
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المشرفين على المادة: 0 (bcl-2-Associated X Protein)
تواريخ الأحداث: Date Created: 20230303 Date Completed: 20230307 Latest Revision: 20230307
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9974255
DOI: 10.1155/2023/9979397
PMID: 36865350
قاعدة البيانات: MEDLINE
الوصف
تدمد:1942-0994
DOI:10.1155/2023/9979397