دورية أكاديمية
Similarity and difference between systemic lupus erythematosus and NZB/W F1 mice by multi-omics analysis.
العنوان: | Similarity and difference between systemic lupus erythematosus and NZB/W F1 mice by multi-omics analysis. |
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المؤلفون: | Okuma K; Center for Innovation in Immunoregulation Technology and Therapeutics, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Drug Discovery Research, Astellas Pharma Inc., Tsukuba, Ibaraki, Japan., Oku T; Center for Innovation in Immunoregulation Technology and Therapeutics, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Drug Discovery Research, Astellas Pharma Inc., Tsukuba, Ibaraki, Japan., Sasaki C; Center for Innovation in Immunoregulation Technology and Therapeutics, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Drug Discovery Research, Astellas Pharma Inc., Tsukuba, Ibaraki, Japan., Kitagori K; Center for Innovation in Immunoregulation Technology and Therapeutics, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Mimori T; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Takeda General Hospital, Kyoto, Japan., Aramori I; Center for Innovation in Immunoregulation Technology and Therapeutics, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Drug Discovery Research, Astellas Pharma Inc., Tsukuba, Ibaraki, Japan., Hirayama Y; Center for Innovation in Immunoregulation Technology and Therapeutics, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Drug Discovery Research, Astellas Pharma Inc., Tsukuba, Ibaraki, Japan., Yoshifuji H; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan. |
المصدر: | Modern rheumatology [Mod Rheumatol] 2024 Feb 26; Vol. 34 (2), pp. 359-368. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 100959226 Publication Model: Print Cited Medium: Internet ISSN: 1439-7609 (Electronic) Linking ISSN: 14397595 NLM ISO Abbreviation: Mod Rheumatol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2021- : Oxford : Oxford University Press Original Publication: Tokyo, Japan : Spring-Verlag Tokyo, c2000- |
مواضيع طبية MeSH: | Multiomics* , Lupus Erythematosus, Systemic*/drug therapy, Mice ; Humans ; Animals ; Rabbits ; Mice, Inbred NZB ; T-Lymphocytes/metabolism ; Cytokines/metabolism ; Disease Models, Animal |
مستخلص: | Objectives: Several animal disease models have been used to understand the mechanisms of systemic lupus erythematosus (SLE); however, the translation of findings from animals to humans has not been sufficiently examined in drug development. To confirm the validity of New Zealand black x New Zealand white (NZB/W) F1 mice as an SLE model, we extensively characterized SLE patients and NZB/W F1 mice by omics analysis. Methods: Peripheral blood from patients and mice and spleen and lymph node tissue from mice were analysed using cell subset analysis, cytokine panel assays, and transcriptome analysis. Results: CD4+ effector memory T cells, plasmablasts, and plasma cells were increased in both SLE patients and NZB/W F1 mice. Levels of tumor necrosis factor-α, interferon gamma induced protein-10, and B cell activating factor in plasma were significantly higher in SLE patients and NZB/W F1 mice than in their corresponding controls. Transcriptome analysis revealed an upregulation of genes involved in the interferon signalling pathway and T-cell exhaustion signalling pathway in both SLE patients and the mouse model. In contrast, death receptor signalling genes showed changes in the opposite direction between patients and mice. Conclusion: NZB/W F1 mice are a generally suitable model of SLE for analysing the pathophysiology and treatment response of T/B cells and monocytes/macrophages and their secreted cytokines. (© Japan College of Rheumatology 2023. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.) |
فهرسة مساهمة: | Keywords: Cytokine; NZB/W F1 mouse; multi-omics; systemic lupus erythematosus; transcriptome |
المشرفين على المادة: | 0 (Cytokines) |
تواريخ الأحداث: | Date Created: 20230304 Date Completed: 20240228 Latest Revision: 20240228 |
رمز التحديث: | 20240228 |
DOI: | 10.1093/mr/road024 |
PMID: | 36869711 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1439-7609 |
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DOI: | 10.1093/mr/road024 |