دورية أكاديمية
[No improvement in live birth rate after luteal phase support by GnRH agonist].
| العنوان: | [No improvement in live birth rate after luteal phase support by GnRH agonist]. |
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| عنوان ترانسليتريتد: | Absence d’amélioration du taux de naissance vivante après soutien de la phase lutéale par agoniste de la GnRH. |
| المؤلفون: | Le Levreur B; Service de gynécologie et de médecine de la reproduction, CHU de Bordeaux, centre Aliénor d'Aquitaine, place Amélie-Raba-Léon, 33076 Bordeaux cedex, France. Electronic address: barbara.le-levreur@chu-bordeaux.fr., Frantz S; Service de gynécologie et de médecine de la reproduction, CHU de Bordeaux, centre Aliénor d'Aquitaine, place Amélie-Raba-Léon, 33076 Bordeaux cedex, France., Lambert M; Service de gynécologie et de médecine de la reproduction, CHU de Bordeaux, centre Aliénor d'Aquitaine, place Amélie-Raba-Léon, 33076 Bordeaux cedex, France., Chansel-Debordeaux L; Service de biologie de la reproduction-CECOS, CHU de Bordeaux, centre Aliénor d'Aquitaine, place Amélie-Raba-Léon, 33076 Bordeaux cedex, France., Bernard V; Service de gynécologie et de médecine de la reproduction, CHU de Bordeaux, centre Aliénor d'Aquitaine, place Amélie-Raba-Léon, 33076 Bordeaux cedex, France., Carriere J; Service de gynécologie et de médecine de la reproduction, CHU de Bordeaux, centre Aliénor d'Aquitaine, place Amélie-Raba-Léon, 33076 Bordeaux cedex, France., Verdy G; Pôle santé publique, CHU de Bordeaux, place Amélie-Raba-Léon, 33076 Bordeaux cedex, France., Hocke C; Service de gynécologie et de médecine de la reproduction, CHU de Bordeaux, centre Aliénor d'Aquitaine, place Amélie-Raba-Léon, 33076 Bordeaux cedex, France. |
| المصدر: | Gynecologie, obstetrique, fertilite & senologie [Gynecol Obstet Fertil Senol] 2023 May; Vol. 51 (5), pp. 249-255. Date of Electronic Publication: 2023 Mar 04. |
| نوع المنشور: | English Abstract; Journal Article |
| اللغة: | French |
| بيانات الدورية: | Publisher: Elsevier Masson SAS Country of Publication: France NLM ID: 101693805 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2468-7189 (Electronic) Linking ISSN: 24687189 NLM ISO Abbreviation: Gynecol Obstet Fertil Senol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Issy-les-Moulineaux : Elsevier Masson SAS, [2017]- |
| مواضيع طبية MeSH: | Abortion, Spontaneous*/epidemiology , Infertility*, Pregnancy ; Female ; Humans ; Progesterone ; Birth Rate ; Gonadotropin-Releasing Hormone ; Retrospective Studies ; Luteal Phase/physiology ; Lipopolysaccharides ; Pregnancy Rate ; Ovulation Induction/methods ; Fertilization in Vitro/methods |
| مستخلص: | Objectives: To evaluate the impact of adding a GnRH agonist (GnRH-a) in luteal phase support (LPS) on live birth rates in IVF/ICSI in antagonist protocols. Methods: In total, 341 IVF/ICSI attempts are analyzed in this retrospective study. Patients were divided into two groups: A f: LPS with progesterone alone (179 attempts) between March 2019 and May 2020; B: LPS with progesterone and an injection of triptorelin (GnRH-a) 0.1mg 6 days after oocyte retrieval (162 attempts) between June 2020 and June 2021. The primary outcome was live birth rate. The secondary outcomes were miscarriage rate, pregnancy rate and ovarian hyperstimulation syndrome rate. Results: The baseline characteristic are identical between the two groups except the infertility duration (longer in the group B). There was no significant difference between the two groups in live birth rate (24.1% versus 21.2%), pregnancy rate (33.3% versus 28.1%), miscarriage rate (4.9% versus 3.4%) and no increase the SHSO rate. The multivariate regression analysis after adjustment for age, ovarian reserve and infertility duration did not reveal a significant difference in live birth rate between the two groups. Conclusion: In this study, the results showed no statistically significant association with the single injection of a GnRH-a in addition to progesterone on live birth rate in luteal phase support. (Copyright © 2023 Elsevier Masson SAS. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Agoniste de la GnRH; Antagonist protocol; FIV; GnRH agonist; IVF; Live birth; Luteal phase support; Naissance vivante; Protocole antagoniste; Soutien de la phase lutéale |
| المشرفين على المادة: | 4G7DS2Q64Y (Progesterone) 33515-09-2 (Gonadotropin-Releasing Hormone) 0 (Lipopolysaccharides) |
| تواريخ الأحداث: | Date Created: 20230305 Date Completed: 20230505 Latest Revision: 20230531 |
| رمز التحديث: | 20240513 |
| DOI: | 10.1016/j.gofs.2023.02.005 |
| PMID: | 36871830 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2468-7189 |
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| DOI: | 10.1016/j.gofs.2023.02.005 |